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Table 4 APO ratio in pregnant patients in clinical remission at conception based on the serological activity

From: Effect of remission, clinical remission with active serology, and glucocorticoid dosage on the pregnancy outcome of pregnant patients with systemic lupus erythematosus

Factor

pregnant in clinical remission at conception

Logistic regression model

clinical remission with active serology

clinical and serological remission

p-value

ORa

95% CI

p-value

n

35

24

    

Overall APO (%)

12 (34.3)

11 (45.8)

0.42

0.62

0.21–1.79

0.37

Maternal APO (%)

7 (20.0)

4 (16.7)

1.00

1.25

0.32–4.85

0.75

Neonatal APO (%)

13 (37.1)

10 (41.7)

0.79

0.83

0.29–2.39

0.73

PROMISSE APO (%)

6 (17.1)

6 (25.0)

0.52

0.62

0.17–2.22

0.46

Flare during pregnancy (%)

2 (5.7)

0 (0.0)

 

NA

NA

 

Flare after delivery (%)

1 (3.1)

0 (0.0)

 

NA

NA

 

Gestational DM (%)

3 (8.6)

1 (4.2)

 

2.16

0.21–22.1

 

Preeclampsia (%)

3 (8.6)

0 (0.0)

 

NA

NA

 

Hypertensive disorders in pregnancy (%)

3 (8.6)

3 (12.5)

 

0.66

0.12–3.56

 

HELLP syndrome (%)

1 (2.9)

0 (0.0)

 

NA

NA

 

Oligohydramnios (%)

1 (2.9)

1 (4.3)

 

0.65

0.04–10.9

 

Maternal death (%)

0 (0.0)

0 (0.0)

 

NA

NA

 

Live birth (%)

32 (91.4)

22 (91.7)

 

0.97

0.15–6.30

 

Total duration of gestation (days)

270.00 [263.50, 276.00]

267.50 [260.00, 273.75]

 

NA

NA

 

Preterm birth (%)

4 (12.5)

4 (18.2)

 

0.64

0.14–2.90

 

Spontaneous abortion (%)

2 (5.7)

0 (0.0)

 

NA

NA

 

Missed abortion (%)

0 (0.0)

1 (4.3)

 

NA

NA

 

Iatrogenic abortion (%)

1 (2.9)

1 (4.2)

 

0.68

0.04–11.4

 

Still birth (%)

0 (0.0)

0 (0.0)

 

NA

NA

 

Height at birth (cm)

48.00 [46.08, 49.10]

48.00 [47.00, 49.50]

 

NA

NA

 

Weight at birth (g)

2716.00 [2539.50, 2935.00]

2776.00 [2419.00, 3062.00]

 

NA

NA

 

Low birth weight (%)

7 (21.9)

8 (36.4)

 

0.49

0.16–1.64

 

SGA (%)

4 (12.5)

4 (18.2)

 

0.64

0.14–2.9

 

Apgar score (1 m)

8.00 [8.00, 8.00]

8.00 [7.25, 8.00]

 

NA

NA

 

Apgar Score (5 m)

9.00 [9.00, 9.00]

9.00 [9.00, 9.00]

 

NA

NA

 

Apgar.score.1 m > 7 (%)

31 (96.9)

22 (100.0)

 

NA

NA

 

Apgar.score.5 m > 7 (%)

32 (100.0)

22 (100.0)

 

NA

NA

 

Major malformation (%)

1 (3.1)

0 (0.0)

 

NA

NA

 

Death of neonate (%)

0 (0.0)

0 (0.0)

 

NA

NA

 
  1. a Odds ratio of serological activity among patients with SLE who achieved clinical remission for each APO
  2. APO; adverse pregnancy outcome, DM; diabetes mellitus, NA; not applicable, OR; odds ratio, PROMISSE; Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Antibody Syndrome and Systemic Lupus Erythematosus, SGA; small for gestational age