Table 5 Glucocorticoid dosage (prednisolone equivalent) ≥ 7.5 mg/day at conception and risk of APO

n

64

32

overall APO (%)

27 (42.2)

22 (68.8)

0.018

3.01

1.23–7.39

0.016

3.11

1.20–8.04

0.019

Maternal APO (%)

14 (21.9)

12 (37.5)

0.14

2.14

0.85–5.43

0.11

2.78

0.98–7.88

0.055

Neonatal APO (%)

25 (39.1)

21 (65.6)

0.018

2.98

1.23–7.22

0.016

2.91

1.14–7.38

0.025

PROMISSE APO (%)

13 (20.3)

9 (28.1)

0.44

1.54

0.58–4.10

0.39

1.59

0.56–4.50

0.38

Flare during pregnancy (%)

2 (3.1)

8 (25.0)

10.3

2.05–42.2

Flare after delivery (%)

1 (1.7)

2 (8.0)

5.04

0.44–58.3

Gestational DM (%)

5 (7.8)

5 (15.6)

2.19

0.58–8.19

Preeclampsia (%)

4 (6.2)

2 (6.2)

1.0

0.17–5.77

Hypertensive disorders in pregnancy (%)

8 (12.5)

5 (15.6)

1.3

0.39–4.34

HELLP syndrome (%)

1 (1.6)

1 (3.1)

2.03

0.12–33.6

Oligohydramnios (%)

2 (3.2)

6 (18.8)

7.04

1.33–37.2

Live birth (%)

59 (92.2)

24 (75.0)

0.25

0.08–0.86

Total duration of gestation (days)

268.0 [262.0, 276.0]

261.00 [234.8, 269.5]

NA

NA

Preterm birth (%)

9 (15.3)

5 (17.9)

1.21

0.36–1.0

Spontaneous abortion (%)

2 (3.2)

1 (3.2)

1.02

0.09–11.7

Missed abortion (%)

1 (1.6)

3 (9.4)

6.31

0.63–63.3

Iatrogenic abortion (%)

2 (3.1)

5 (15.6)

5.74

1.05–31.5

Still birth (%)

0 (0.0)

0 (0.0)

NA

NA

Height at birth (cm)

47.9 [46.2, 49.4]

46.2 [44.1, 48.1]

NA

NA

Weight at birth (g)

2732.0 [2461.0, 3014.5]

2421.0 [2168.0, 2825.8]

NA

NA

Low birth weight (%)

17 (28.8)

13 (54.2)

2.92

1.09–7.79

SGA (%)

8 (13.6)

6 (25.0)

2.13

0.65–6.96

Apgar score (1 m)

8.00 [8.00, 8.00]

8.00 [8.00, 8.25]

NA

NA

Apgar Score (5 m)

9.00 [9.00, 9.00]

9.00 [9.00, 9.00]

NA

NA

Apgar.score.1 m > 7 (%)

57 (96.6)

23 (95.8)

0.81

0.07–9.34

Apgar.score.5 m > 7 (%)

59 (100.0)

24 (100.0)

NA

NA

Major malformation (%)

2 (3.4)

0 (0.0)

NA

NA

Death of neonate

0 (0.0)

0 (0.0)

NA

NA