Fig. 7
From: TfR1 mediated iron metabolism dysfunction as a potential therapeutic target for osteoarthritis
Fer-II alleviated post-traumatic OA progression. 24 mice were randomly divided in three groups and intra-articular injected Feristatin II solution followed by DMM surgery. (A) Micro-CT analysis, 3D reconstruction, and X-ray images of knee joints. scale bar = 1 mm. (B) Quantification of microarchitecture parameters [bone volume per tissue volume (BV/TV)] of the medial tibial plateau of mice knees. (C-D) HE staining of joints in the Ctrl group, DMM group, and Fer-II group and the OARSI scores. scale bar = 100 μm. (E-H) Representative IHC images and quantification of TfR1, STING, COL2, MMP3, in chondrocytes of three groups. Scale bar = 100 μm. Data are presented as mean ± SD from three independent experiments. **P < 0.01, ***P < 0.001, ****P < 0.0001