Fig. 3
Synovial histopathology and synovitis grading during experimental OA development. Representative images of H&E-stained synovium at 4- and 12-weeks post surgery (A). The scale bar represents 100μm, the thick arrow; synovial hyperplasia, thin arrow; sub synovial infiltrate, star; angiogenesis, and arrowhead; synovial fibrosis. Individual measures of synovial histopathology at 4-weeks (●) and 12-weeks (◼) post surgery with comparisons to Veh-lip. The y-axis shows the total histopathological score (out of 18) and the x-axis the treatment group. Mean with 95% confidence intervals are displayed, **** p<0.0001, *** p<0.001, ** p<0.01, * p<0.05