Fig. 4

Cartilage histopathology and degeneration grading during experimental OA development. Representative images of toluidine blue stained cartilage at 4- and 12-weeks post surgery (A). The scale bar represents 500μm, and the arrowhead areas of cartilage degeneration. Measures of cartilage degeneration in the medial and lateral tibial plateau and femoral condyles at 4-weeks (●) and 12-weeks (◼) post surgery. The y-axis shows the total histopathological score (out of 60) or individual histopathological score (out of 15) and the x-axis the treatment group. Mean with 95% confidence intervals are displayed