Fig. 6

Effects of macrophage-targeted treatment on co-cultured articular chondrocyte sGAG secretion and gene expression. sGAG production by chondrocytes after co-culture with synovial tissue explants from experimental OA knees treated with liposomal treatments for 4- (●) and 12-weeks (◼) (A). The Y-axis represents concentration (μg/mL) of sGAGs in media collected after 24 hours of co-culture, * p=0.03. Gene expression of naïve chondrocytes co-cultured with synovial explants from 4- (●) and 12-week (◼) animals (B). The y-axis represents fold change (2^-ΔΔCq) and the x-axis treatment group. Mean with 95% confidence intervals are displayed, **** p<0.0001, *** p<0.001, ** p<0.01, * p<0.05