Fig. 2
From: Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Over-Representation analysis (ORA) of enriched KEGG pathways, GO BP and CC in IgAV patients vs. HC, IgAVN vs. HC and sl-IgAV vs. HC performed on the gene sets derived from RNA sequencing data. Each bar on the graph represents a biological term, such as KEGG pathway, BP, or CC. Enriched terms are color-coded, with red colors indicating higher significance. The level of statistical significance is expressed with p-adj values. Hypergeometric test was employed to determine if the observed enrichment exceeded what might be expected by chance. The adjusted p value was computed using the Benjamini-Hochberg procedure, and a q value threshold of 0.05 was set to deem enriched terms as significant. The x-axis shows gene count. KEGG, Kyoto Encyclopedia of Genes and Genomes; GO, Gene Ontology; BP, Biological Processes; CC, Cellular Components; IgAV, immunoglobulin A vasculitis; HC, healthy controls; IgAVN, IgAV with renal involvement; sl-IgAV, skin-limited IgAV.