Fig. 4
From: Deregulation in adult IgA vasculitis skin as the basis for the discovery of novel serum biomarkers
Measured analytes distinguishing between sl-IgAV, IgAVN and IgAV_GI. (a) LBP concentration was significantly higher in IgAVN as compared to sl-IgAV patients as calculated using Mann Whitney U Test. (b) ROC curve of LBP for predicting renal involvement. (c) Serum levels of adiponectin and CXCL10 were significantly lower in all patients with GI involvement (IgAV_GI & IgAVN + GI) as compared to those without. (d) ROC curve of adiponectin and CXCL10 for predicting renal involvement. (e) Serum levels of CCL19, osteopontin and ANGPTL4 were significantly elevated in IgAV patients with necrotic skin lesions. P-values were calculated using Mann Whitney U Test. Data are expressed as medians (Q25-Q75) of each group. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. PC, principal component; ROC, Receiver operating characteristic; IgAV, immunoglobulin A vasculitis; sl-IgAV, skin-limited IgAV; IgAVN, IgAV with renal involvement; IgAV_GI, IgA with gastrointestinal involvement (GI); IgAVN + GI, IgAV with GI and renal involvement; HC, healthy controls; LBP, Lipopolysaccharide binding protein; CXCL, C-X-C motif chemokine ligand; CCL, Chemokine (C-C motif) ligand; ANGPTL4, angiopoietin-like 4