Table 1 Measured protein analytes in sera of adult IgAV patients as compared to HC

Serum analyte

IgAV (n = 59)

HC (n = 22)

p-adj value (Mann-Whitney U test)

p-adj (linear regression adjusted for age and sex)

Fold change

Adiponectin

6.08 (4.59–7.73)

5.54 (4.42–7.24)

5.92e^− 1

7.80e^− 1

1.10

LBP

14.63 (9.90–20.3)

6.23 (4.9–7.71)

1.43e^− 6

1.79e^− 3

2.35

MMP1

4.46 (2.57–8.56)

1.47 (3.07–4.75)

9.09e^− 3

3.86e^− 3

1.45

CCL19

123.4 (79.8-196.2)

73.9 (35.2–93.9)

1.20e^− 3

1.41e^− 3

1.67

kallikrein-5

309.4 (137.3-559.8)

51.8 (4.50–224.0)

1.20e^− 3

9.87e^− 4

5.97

CCL3

290.9 (243.6-378.5)

214.6 (129.2-288.3)

2.59e^− 3

4.37e^− 3

1.36

leptin

9.15 (5.64–18.5)

4.80 (2.21–6.81)

2.84e^− 3

5.60e^− 3

2.35

CXCL5

1.34 (1-02-1.99)

1.42 (0.99–2.02)

8.28e^− 1

8.77e^− 1

0.950

Osteopontin

42.8 (30.1–77.9)

10.1 (6.65-20.0)

4.20e^− 7

2.73e^− 8

4.25

IL-15

3.29 (4.91–5.72)

6.52 (5.72–9.72)

2.32e^− 5

3.19e^− 7

1.33

CXCL10

32.1 (22.5–48.6)

25.8 (20.7–36.9)

2.16e^− 1

1.22e^− 1

1.24

ANGPTL4

217.6 (132.9-312.9)

113.2 (88.4–131.0)

1.79e^− 5

3.13e^− 7

1.92

SERPIN A12

0.2 (0.1–0.33)

0.22 (0.1–0.64)

4.40e^− 1

2.40e^− 1

0.902

IL-18

0.17 (0.12–0.23)

0.12 (0.10–0.15)

3.45e^− 3

5.60e^− 3

1.47

FABP4

44.6 (21.1–77.9)

16.0 (10.2–20.8)

3.74e^− 5

2.67e^− 7

2.78