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  1. Research article

    Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

    The aim was to investigate CD4+T-cell subsets, immune cells and their cytokine profiles in blood and synovial compartments in rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA) to define specific immu...

    Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat and Pier Luigi Meroni

    Arthritis Research & Therapy 2017 19:103

    Published on: 19 May 2017

  2. Research article

    B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients

    B cell depletion with rituximab (RTX) is approved for treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitides (AAV). Recently, RTX has been shown to be effective in AAV maintenance therapy, but...

    Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner, Arianna Troilo, Raquel Lorenzetti, Reinhard E. Voll and Nils Venhoff

    Arthritis Research & Therapy 2017 19:101

    Published on: 18 May 2017

  3. Research article

    TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study

    Magnetic resonance imaging (MRI) and computed tomography (CT) angiography have now largely replaced interventional angiography in the diagnoses and follow up of Takayasu arteritis (TAK) but data on the effects...

    Birgir Gudbrandsson, Øyvind Molberg and Øyvind Palm

    Arthritis Research & Therapy 2017 19:99

    Published on: 18 May 2017

  4. Research article

    M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

    Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repai...

    Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg and Johanna Westra

    Arthritis Research & Therapy 2017 19:100

    Published on: 18 May 2017

  5. Research article

    Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

    To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyl...

    Karin Bengtsson, Helena Forsblad-d’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling and Lennart T. H. Jacobsson

    Arthritis Research & Therapy 2017 19:102

    Published on: 18 May 2017

  6. Research article

    Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

    Osteoarthritis has a high prevalence in people with high bone mineral density (BMD). Nevertheless, whether high systemic BMD predates early structural features of knee osteoarthritis is unclear. This study exa...

    Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka, Boyd J. Strauss, Joseph Proietto, John B. Dixon, Graeme Jones and Flavia M. Cicuttini

    Arthritis Research & Therapy 2017 19:98

    Published on: 18 May 2017

  7. Research article

    The performance of different classification criteria sets for spondyloarthritis in the worldwide ASAS-COMOSPA study

    In this study, we sought to compare the performance of spondyloarthritis (SpA) classification criteria sets in an international SpA cohort with patients included from five continents around the world.

    Pauline Bakker, Anna Moltó, Adrien Etcheto, Filip Van den Bosch, Robert Landewé, Floris van Gaalen, Maxime Dougados and Désirée van der Heijde

    Arthritis Research & Therapy 2017 19:96

    Published on: 16 May 2017

  8. Research article

    Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

    Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aim...

    Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto and Keishi Fujio

    Arthritis Research & Therapy 2017 19:97

    Published on: 16 May 2017

  9. Research article

    Development of a clinical prediction algorithm for knee osteoarthritis structural progression in a cohort study: value of adding measurement of subchondral bone density

    Risk prediction algorithms increase understanding of which patients are at greatest risk of a harmful outcome. Our goal was to create a clinically useful prediction algorithm for structural progression of knee...

    Michael P. LaValley, Grace H. Lo, Lori Lyn Price, Jeffrey B. Driban, Charles B. Eaton and Timothy E. McAlindon

    Arthritis Research & Therapy 2017 19:95

    Published on: 16 May 2017

  10. Research article

    Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis

    Prolactin (PRL) reduces joint inflammation, pannus formation, and bone destruction in rats with polyarticular adjuvant-induced arthritis (AIA). Here, we investigate the mechanism of PRL protection against bone...

    Maria G. Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera and Carmen Clapp

    Arthritis Research & Therapy 2017 19:93

    Published on: 15 May 2017

  11. Research article

    Costs associated with failure to respond to treatment among patients with rheumatoid arthritis initiating TNFi therapy: a retrospective claims analysis

    Tumor necrosis factor inhibitors (TNFi) are common second-line treatments for rheumatoid arthritis (RA). This study was designed to compare the real-world clinical and economic outcomes between patients with R...

    Michael Grabner, Natalie N. Boytsov, Qing Huang, Xiang Zhang, Tingjian Yan and Jeffrey R. Curtis

    Arthritis Research & Therapy 2017 19:92

    Published on: 15 May 2017

  12. Research article

    Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling

    Abnormal B-cell activation is implicated in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). The B-cell surface molecule CD22, which regulates activation through the B-cel...

    Natalia V. Giltiay, Geraldine L. Shu, Anthony Shock and Edward A. Clark

    Arthritis Research & Therapy 2017 19:91

    Published on: 15 May 2017

  13. Research article

    Disturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study

    Utilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the potential to identify malperfusion by little to no ti...

    Stefanie Friedrich, Susanne Lüders, Stephanie Gabriele Werner, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus and Sarah Ohrndorf

    Arthritis Research & Therapy 2017 19:87

    Published on: 8 May 2017

  14. Research article

    The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

    Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for C...

    Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay and Khaled A. Elsaid

    Arthritis Research & Therapy 2017 19:89

    Published on: 8 May 2017

  15. Research article

    Models solely using claims-based administrative data are poor predictors of rheumatoid arthritis disease activity

    This study developed and validated a claims-based statistical model to predict rheumatoid arthritis (RA) disease activity, measured by the 28-joint count Disease Activity Score (DAS28).

    Brian C. Sauer, Chia-Chen Teng, Neil A. Accortt, Zachary Burningham, David Collier, Mona Trivedi and Grant W. Cannon

    Arthritis Research & Therapy 2017 19:86

    Published on: 8 May 2017

  16. Research article

    Multicenter inception cohort of enthesitis-related arthritis: variation in disease characteristics and treatment approaches

    Enthesitis-related arthritis (ERA) is a specific subtype of juvenile idiopathic arthritis (JIA) defined according to the International League of Associations for Rheumatology (ILAR) criteria. We aimed to chara...

    Sabrina Gmuca, Rui Xiao, Timothy G. Brandon, Ilaria Pagnini, Tracey B. Wright, Timothy Beukelman, Esi M. Morgan and Pamela F. Weiss

    Arthritis Research & Therapy 2017 19:84

    Published on: 2 May 2017

  17. Research article

    Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers

    Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in pat...

    Elena Rykova, Aleksey Sizikov, Dirk Roggenbuck, Oksana Antonenko, Leonid Bryzgalov, Evgeniy Morozkin, Kseniya Skvortsova, Valentin Vlassov, Pavel Laktionov and Vladimir Kozlov

    Arthritis Research & Therapy 2017 19:85

    Published on: 2 May 2017

  18. Research article

    Monosodium urate crystal deposition associated with the progress of radiographic grade at the sacroiliac joint in axial SpA: a dual-energy CT study

    Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by the insidiously progressive nature of sacroiliitis and spondylit...

    Junqing Zhu, Aiwu Li, Ertao Jia, Yi Zhou, Juan Xu, Shixian Chen, Yinger Huang, Xiang Xiao and Juan Li

    Arthritis Research & Therapy 2017 19:83

    Published on: 2 May 2017

  19. Research article

    Clinical and demographic factors associated with change and maintenance of disease severity in a large registry of patients with rheumatoid arthritis

    We examined models to predict disease activity transitions from moderate to low or severe and associated factors in patients with rheumatoid arthritis (RA).

    George W. Reed, David H. Collier, Andrew S. Koenig, Katherine C. Saunders, Dimitrios A. Pappas, Heather J. Litman, Joel M. Kremer and Sameer Kotak

    Arthritis Research & Therapy 2017 19:81

    Published on: 27 April 2017

  20. Research article

    Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis

    Calgizzarin (S100A11) is a member of the S100 protein family that acts in different tumors by regulating a number of biologic functions. Recent data suggest its association with low-grade inflammation in osteo...

    Lucie Andrés Cerezo, Barbora Šumová, Klára Prajzlerová, David Veigl, Dres Damgaard, Claus Henrik Nielsen, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt

    Arthritis Research & Therapy 2017 19:79

    Published on: 26 April 2017

  21. Research article

    Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets

    Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We stu...

    Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L. Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M. Lindegaard, Jakob M. Møller and Peter Junker

    Arthritis Research & Therapy 2017 19:80

    Published on: 26 April 2017

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