- Paper Report
- Open Access
Associate Professor of Medicine
- Richard Brasington1
© Current Science Ltd 2000
- Published: 4 October 2000
- Collagen Induced Arthritis
- complement regulatory proteins
- gene therapy
The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Soluble complement receptor 1 (sCR1) regulates complement activity, and may be useful as a therapeutic agent. This study tests the hypothesis that delivery of genes encoding truncated sCR1 (tsCR1) is an effective treatment for collagen-induced arthritis (CIA), a murine model for RA.
DBA/1 mice immunized with bovine type II collagen, then injected with syngeneic, immortalized fibroblasts transduced with tsCR1, developed less severe CIA and had less abnormal histological scores than control mice. The authors conclude that gene therapy with tsCR1 is a feasible therapy for CIA.
Gene therapy via injection of transduced immortalized fibroblasts