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  1. Content type: Research article


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Professor Christopher Buckley, University of Birmingham and University of Oxford, UK
Professor Harris Perlman, Northwestern University, USA

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Aims and scope

Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports.
A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care.
Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.

Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren’s syndrome differ in molecular signatures and treatment perspectives

© Idborg et al, 2019Existing literature on patients with systmetic lupus erythematosus (SLE) suggest that SLE harbors distinct immunophenotypes. Idborg et al investigate how SLE subgroups may differ regarding underlying pathophysiology and characteristic biomarkers.

Their observations indicate underlying pathogenic differences between the SSA/SSB+ and the aPL+ SLE subgroups, suggesting that the SSA/SSB+ subgroup may benefit from IFN-blocking therapies while the aPL+ subgroup is more likely to have an effect from drugs targeting the complement system.


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