Arthritis Research & Therapy

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Research article

Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten and Kris A. Reedquist

Published on: 18 September 2017
Research article

Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment

Michael Schiff, Tsutomu Takeuchi, Roy Fleischmann, Carol L. Gaich, Amy M. DeLozier, Douglas Schlichting, Wen-Ling Kuo, Ji-Eon Won, Tara Carmack, Terence Rooney, Patrick Durez, Saeed Shaikh, Rodolfo Pardo Hidalgo, Ronald van Vollenhoven and Cristiano A. F. Zerbini

Published on: 18 September 2017
Review

Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review

YuKai Wang, Luna Gargani, Tatiana Barskova, Dan E. Furst and Marco Matucci Cerinic

Published on: 18 September 2017
Research article

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song and Qiang Zhou

Published on: 18 September 2017
Editorial

Inflammasome lights up in systemic sclerosis

John Henderson and Steven O’Reilly

Published on: 18 September 2017

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Review

Use of NSAIDs in treating patients with arthritis

Leslie J Crofford

Published on: 24 July 2013
Review

Complement and systemic lupus erythematosus

Mark J Walport

Published on: 9 May 2002
Research article

Remission in psoriatic arthritis: is it possible and how can it be predicted?

Tajvur P Saber, CT Ng, Guillaume Renard, Bernadette M Lynch, Eliza Pontifex, Ceara AE Walsh, Alexia Grier, Marian Molloy, Barry Bresnihan, Oliver FitzGerald, Ursula Fearon and Douglas J Veale

Published on: 18 May 2010
Research article

Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis

Michel PM Vierboom, Elia Breedveld, Ivanela Kondova and Bert A 't Hart

Published on: 26 October 2010
Review

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

Guangyi Li, Jimin Yin, Junjie Gao, Tak S Cheng, Nathan J Pavlos, Changqing Zhang and Ming H Zheng

Published on: 9 December 2013

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Article collections

Rheumatology around the world

Measuring meaningful change in lupus clinical trials

Biology and clinical applications of stem cells for autoimmune and musculoskeletal disorders

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Editors-in-Chief

Professor Christopher Buckley, University of Birmingham and University of Oxford, UK
Professor Harris Perlman, Northwestern University, USA

Aims and scope

Arthritis Research & Therapy is an international, peer-reviewed online journal, publishing original research, reviews, commentaries and reports. The major focus of the journal is on cellular and molecular mechanisms of arthritis, musculoskeletal conditions and systemic autoimmune rheumatic diseases and translation of this knowledge into advances in clinical care. Original basic, translational laboratory and clinical research is considered for publication along with results of early and late phase therapeutic trials.

Review series: New technologies

Written by renowned experts in the field, this collection of open access Review articles explores the use of RNA sequencing, cytometry, metabolomics and next-generation DNA sequencing in rheumatic disease.

Reflections of a rheumatologist

The role of mitochondria in immune-mediated disease: the dangers of a split personality

Read more from David Pisetsky

Featured review: Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis

New Content Item In this review, Bustamante and colleagues show how fibroblast-like synoviocytes in RA patients differ from healthy synovial fibroblasts, not only in their marker expression, proto-oncogene expression, or their epigenetic changes, but also in their intracellular metabolism.

"Whether this truly constitutes an option to increase the drug armamentarium in rheumatic diseases beyond biological and kinase inhibitor therapies remains to be determined."