Aims and scope
Review series: New technologies
Written by renowned experts in the field, this collection of open access Review articles explores the use of RNA sequencing, cytometry, metabolomics and next-generation DNA sequencing in rheumatic disease.
Reflections of a rheumatologist
Featured review: Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis
In this review, Bustamante and colleagues show how fibroblast-like synoviocytes in RA patients differ from healthy synovial fibroblasts, not only in their marker expression, proto-oncogene expression, or their epigenetic changes, but also in their intracellular metabolism.
"Whether this truly constitutes an option to increase the drug armamentarium in rheumatic diseases beyond biological and kinase inhibitor therapies remains to be determined."