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Reflections of a rheumatologist

The biological functions of DNA: from the sublime to the slime

Read more from David Pisetsky


Professor Christopher Buckley, University of Birmingham and University of Oxford, UK
Professor Harris Perlman, Northwestern University, USA

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Aims and scope

Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports.
A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care.
Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.

Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials

© ChrisChrisW / Getty Images / iStockCurrent treatments of osteoarthritis (OA) mainly focus on relieving pain and stiffness or improving function and quality of life. High placebo responses (PRs) in OA trials are believed to have contributed to the long list of failures of OA trials to date.
In this meta-analysis review, Huang et al evaluate the contextual effects in the form of PRs for patient reported pain and function, and objectively measured function in clinical trials of OA of the knee, hip, foot, or hand.


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