Arthritis Research & Therapy

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Research article

Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo and Feng Zhang

Published on: 25 July 2017
Research article

Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Yang Zhang, Xiaochun Wei, Shawn Browning, Gaetano Scuderi, Lewis S. Hanna and Lei Wei

Published on: 25 July 2017
Research article

Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

Sunao Sugita, Jun Shimizu, Kenichi Makabe, Hiroshi Keino, Takeshi Watanabe and Masayo Takahashi

Published on: 25 July 2017
Research article

CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

Cristiano Alessandri, Francesco Ciccia, Roberta Priori, Elisa Astorri, Giuliana Guggino, Riccardo Alessandro, Aroldo Rizzo, Fabrizio Conti, Antonina Minniti, Cristiana Barbati, Marta Vomero, Monica Pendolino, Annacarla Finucci, Elena Ortona, Tania Colasanti, Marina Pierdominici…

Published on: 25 July 2017
Research article

RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

Xavier Suárez-Calvet, Eduard Gallardo, Iago Pinal-Fernandez, Noemi De Luna, Cinta Lleixà, Jordi Díaz-Manera, Ricardo Rojas-García, Ivan Castellví, M. Angeles Martínez, Josep M. Grau, Albert Selva-O’Callaghan and Isabel Illa

Published on: 24 July 2017

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Review

Use of NSAIDs in treating patients with arthritis

Leslie J Crofford

Published on: 24 July 2013
Research article

Remission in psoriatic arthritis: is it possible and how can it be predicted?

Tajvur P Saber, CT Ng, Guillaume Renard, Bernadette M Lynch, Eliza Pontifex, Ceara AE Walsh, Alexia Grier, Marian Molloy, Barry Bresnihan, Oliver FitzGerald, Ursula Fearon and Douglas J Veale

Published on: 18 May 2010
Research article

Collagen-induced arthritis in common marmosets: a new nonhuman primate model for chronic arthritis

Michel PM Vierboom, Elia Breedveld, Ivanela Kondova and Bert A 't Hart

Published on: 26 October 2010
Review

Complement and systemic lupus erythematosus

Mark J Walport

Published on: 9 May 2002
Review

Microbes, the gut and ankylosing spondylitis

Mary-Ellen Costello, Dirk Elewaut, Tony J Kenna and Matthew A Brown

Published on: 6 June 2013

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Article collections

Rheumatology around the world

Measuring meaningful change in lupus clinical trials

Biology and clinical applications of stem cells for autoimmune and musculoskeletal disorders

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Editors-in-Chief

Professor Christopher Buckley, University of Birmingham and University of Oxford, UK
Professor Harris Perlman, Northwestern University, USA

Aims and scope

Arthritis Research & Therapy is an international, peer-reviewed online journal, publishing original research, reviews, commentaries and reports. The major focus of the journal is on cellular and molecular mechanisms of arthritis, musculoskeletal conditions and systemic autoimmune rheumatic diseases and translation of this knowledge into advances in clinical care. Original basic, translational laboratory and clinical research is considered for publication along with results of early and late phase therapeutic trials.

Review series: New technologies

Written by renowned experts in the field, this collection of open access Review articles explores the use of RNA sequencing, cytometry, metabolomics and next-generation DNA sequencing in rheumatic disease.

Reflections of a rheumatologist

The role of mitochondria in immune-mediated disease: the dangers of a split personality

Read more from David Pisetsky

Featured review: Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis

New Content Item In this review, Bustamante and colleagues show how fibroblast-like synoviocytes in RA patients differ from healthy synovial fibroblasts, not only in their marker expression, proto-oncogene expression, or their epigenetic changes, but also in their intracellular metabolism.

"Whether this truly constitutes an option to increase the drug armamentarium in rheumatic diseases beyond biological and kinase inhibitor therapies remains to be determined."