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  1. Content type: Research article


    Authors: Clarissa de Castro Ferreira, Ana Carolina Campi-Azevedo, Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Karen Torres, Larissa Chaves Freire, Ismael Artur da Costa-Rocha, Ana Cristina Vanderley Oliveira, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho and Lícia Maria Henrique da Mota

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Professor Christopher Buckley, University of Birmingham and University of Oxford, UK
Professor Harris Perlman, Northwestern University, USA

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Aims and scope

Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports.
A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care.
Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.

Synovitis in osteoarthritis: current understanding with therapeutic implications

New Content ItemIn this review, Mathiessen and Conaghan review current knowledge on the prevalence of synovitis in osteoarthritis and its role in symptoms and structural progression, and explore lessons learnt from targeting synovitis therapeutically.

"Overall evidence suggests that synovial inflammation is associated with progressive joint failure at least in a subgroup of patients, and thus some osteoarthritis patients may benefit structurally from an anti-inflammatory intervention. "


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