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  1. Content type: Research article

    The impact of smoking on TNF inhibition (TNFi) therapy is unclear. We examined the effect of smoking on all-cause and cause-specific TNFi discontinuation in axial spondyloarthritis (axSpA).

    Authors: Sizheng Steven Zhao, Kazuki Yoshida, Gareth T. Jones, David M. Hughes, Stephen J. Duffield, Sara K. Tedeschi, Houchen Lyu, Robert J. Moots, Daniel H. Solomon and Nicola J. Goodson

    Citation: Arthritis Research & Therapy 2019 21:177

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  2. Content type: Research article

    This study evaluates the utility of urinary pro-thrombotic molecules such as tissue factor (TF), anti-thrombotic molecules such as tissue factor pathway inhibitor (TFPI), and fibrinolytic molecules such as pla...

    Authors: Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena and Chandra Mohan

    Citation: Arthritis Research & Therapy 2019 21:176

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  3. Content type: Research article

    Primary Sjögren syndrome (pSS) is characterized by T and B cell infiltration of exocrine glands. The cysteine protease cathepsin S (CatS) is crucially involved in MHCII processing and T cell stimulation, and e...

    Authors: Patrick Hargreaves, Douglas Daoudlarian, Michel Theron, Fabrice A. Kolb, Marianne Manchester Young, Bernhard Reis, Andre Tiaden, Bettina Bannert, Diego Kyburz and Tobias Manigold

    Citation: Arthritis Research & Therapy 2019 21:175

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  4. Content type: Research article

    Rheumatoid arthritis (RA) is known to cause secondary osteoporosis and fragility fractures. This study aimed to identify biomarkers predictive of bone mineral density (BMD) change at three anatomical sites in ...

    Authors: T. Tomizawa, H. Ito, K. Murata, M. Hashimoto, M. Tanaka, K. Murakami, K. Nishitani, M. Azukizawa, A. Okahata, K. Doi, M. Saito, M. Furu, M. Hamaguchi, T. Mimori and S. Matsuda

    Citation: Arthritis Research & Therapy 2019 21:174

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  5. Content type: Review

    To evaluate contextual effects in the form of placebo responses (PRs) for patient-reported pain and function and objectively measured function in osteoarthritis (OA) clinical trials.

    Authors: ZeYu Huang, Jing Chen, Qin Sheng Hu, Qiang Huang, Jun Ma, Fu Xing Pei, Bin Shen and Virginia Byers Kraus

    Citation: Arthritis Research & Therapy 2019 21:173

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  6. Content type: Research article

    Syndecans are heparan sulfate proteoglycans that occur in membrane-bound or soluble forms. Syndecan-3, the least well-characterised of the syndecan family, is highly expressed on synovial endothelial cells in ...

    Authors: Andrew D. Eustace, Emily F. McNaughton, Sophie King, Oksana Kehoe, Andreas Kungl, Derek Mattey, Angela H. Nobbs, Neil Williams and Jim Middleton

    Citation: Arthritis Research & Therapy 2019 21:172

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  7. Content type: Research article

    Autophagy induction is an effective approach for OA therapy. IL-1β is one of the major inflammatory cytokines linked to OA pathological progression, and its receptor blockade interrupts OA cartilage destructio...

    Authors: Fen Wang, Jijie Liu, Xiaolei Chen, Xinpeng Zheng, Ning Qu, Bing Zhang and Chun Xia

    Citation: Arthritis Research & Therapy 2019 21:171

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  8. Content type: Correction

    Following publication of the original article [1], it has come to our attention that we did not appropriately convert the units for CRP from the National Health and Nutrition Examination Survey (NHANES) from m...

    Authors: Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon and Katherine P. Liao

    Citation: Arthritis Research & Therapy 2019 21:170

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    The original article was published in Arthritis Research & Therapy 2018 20:107

  9. Content type: Research article

    Triggering receptor expressed on myeloid cells-1 (TREM-1) is inducible on monocyte/macrophages and neutrophils and amplifies the inflammatory response. The aim of this study was to determine whether rheumatoid...

    Authors: Anping Peng, Xinyi Lu, Jun Huang, Min He, Jianhua Xu, Hui Huang and Qubo Chen

    Citation: Arthritis Research & Therapy 2019 21:169

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  10. Content type: Research article

    To compare the long-term disease state, in terms of activity and damage, of children with juvenile idiopathic arthritis (JIA) who had their disease onset in methotrexate (MTX) or biologic eras.

    Authors: Gabriella Giancane, Valentina Muratore, Valentina Marzetti, Neus Quilis, Belen Serrano Benavente, Francesca Bagnasco, Alessandra Alongi, Adele Civino, Lorenzo Quartulli, Alessandro Consolaro and Angelo Ravelli

    Citation: Arthritis Research & Therapy 2019 21:168

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  11. Content type: Research article

    While bone marrow-derived mesenchymal stem cells (BMSC) are established sources for stem cell-based cartilage repair therapy, articular cartilage-derived mesenchymal stem cells from osteoarthritis patients (OA...

    Authors: Nan Hu, Yun Gao, Chathuraka T. Jayasuriya, Wenguang Liu, Heng Du, Jing Ding, Meng Feng and Qian Chen

    Citation: Arthritis Research & Therapy 2019 21:167

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  12. Content type: Research article

    To assess if the right hand, the dominant hand, or the hand with more clinically swollen joints (SwJ) is per se the most inflamed and exhibits the greatest change during treatment and hence preferred for unila...

    Authors: Lene Terslev, Robin Christensen, Anna-Birgitte Aga, Joe Sexton, Espen A. Haavardsholm and Hilde B. Hammer

    Citation: Arthritis Research & Therapy 2019 21:166

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  13. Content type: Research article

    Low back pain is the largest contributor to disability worldwide. The role of body composition as a risk factor for back pain remains unclear. Our aim was to examine the relationship between fat mass and fat d...

    Authors: Sharmayne R. E. Brady, Donna M. Urquhart, Sultana Monira Hussain, Andrew Teichtahl, Yuanyuan Wang, Anita E. Wluka and Flavia Cicuttini

    Citation: Arthritis Research & Therapy 2019 21:165

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  14. Content type: Research article

    Biologic disease-modifying antirheumatic drugs (bDMARDs) are important options for managing rheumatoid arthritis (RA). Once patients achieve disease control, clinicians may consider dose reduction or withdrawa...

    Authors: Yoshiya Tanaka, Josef S. Smolen, Heather Jones, Annette Szumski, Lisa Marshall and Paul Emery

    Citation: Arthritis Research & Therapy 2019 21:164

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  15. Content type: Research article

    To investigate the association between the extent of tapering tumor necrosis factor inhibitor (TNFi) and the likelihood of achieving inactive disease in patients with axial spondyloarthritis (axSpA)

    Authors: Jun Won Park, Hyoun-Ah Kim, Kichul Shin, Yong-Beom Park, Tae-Hwan Kim, Yeong Wook Song and Eun Young Lee

    Citation: Arthritis Research & Therapy 2019 21:163

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  16. Content type: Research article

    To address whether the use of methotrexate (MTX) and biological disease-modifying anti-rheumatic drugs (bDMARDs) impacts bone structure and biomechanical properties in patients with psoriatic arthritis (PsA).

    Authors: David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2019 21:162

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  17. Content type: Research article

    Thrombocytopenia is a manifestation associated with primary antiphospholipid syndrome (PAPS), and many studies have stressed the leading role played by platelets in the pathogenesis of antiphospholipid syndrom...

    Authors: C. Barbati, L. Stefanini, T. Colasanti, E. Cipriano, A. Celia, G. Gabriele, M. Vomero, F. Ceccarelli, F. R. Spinelli, A. Finucci, M. Speziali, G. Orso, D. P. E. Margiotta, F. Conti, F. Violi, A. Afeltra…

    Citation: Arthritis Research & Therapy 2019 21:161

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  18. Content type: Research article

    To examine the feasibility, preference, and satisfaction of an interactive voice response (IVR) system versus a customized smartphone application (StudyBuddy) to capture gout flares

    Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, David Redden, Lang Chen, Cooper Filby, Jeffrey R. Curtis, Ted R. Mikuls and Kenneth G. Saag

    Citation: Arthritis Research & Therapy 2019 21:160

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  19. Content type: Research article

    Th17 cells are involved in the pathogenesis of ankylosing spondylitis (AS). However, the mechanism underlying enhanced Th17 cell accumulation in AS remains unknown. The prostaglandin E2 receptor EP2/EP4 signaling...

    Authors: Charlotte Klasen, Anja Meyer, Paula S. Wittekind, Iris Waqué, Schafiq Nabhani and David M. Kofler

    Citation: Arthritis Research & Therapy 2019 21:159

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  20. Content type: Research article

    People with hand-related rheumatoid arthritis (RA) experience problems performing activities of daily living (ADL). Compensatory strategies to improve ADL ability have shown effective. Similarly, hand exercise...

    Authors: Karen Ellegaard, Cecilie von Bülow, Alice Røpke, Cecilie Bartholdy, Inge Skovby Hansen, Signe Rifbjerg-Madsen, Marius Henriksen and Eva Ejlersen Wæhrens

    Citation: Arthritis Research & Therapy 2019 21:158

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  21. Content type: Research article

    Low-dose methotrexate (MTX) is the first-line therapy in early rheumatoid arthritis (eRA). Up to 40% of eRA patients do not benefit from MTX therapy. MTX has been shown to inhibit one-carbon metabolism, which ...

    Authors: Helen R. Gosselt, Bertrand D. van Zelst, Maurits C. F. J. de Rotte, Johanna M. W. Hazes, Robert de Jonge and Sandra G. Heil

    Citation: Arthritis Research & Therapy 2019 21:157

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  22. Content type: Research article

    GATA3 is a transcription factor that is important during development and plays a role in differentiation and activity of immune cells, particularly T cells. Abnormal T cell function is found in autoimmune arth...

    Authors: Anna E. Patrick, Wei Wang, Elly Brokamp, Thomas Brent Graham, Thomas M. Aune and Jessica B. Duis

    Citation: Arthritis Research & Therapy 2019 21:156

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  23. Content type: Research article

    Healthcare access, utilization, and quality play critical roles in shaping mortality and morbidity among patients diagnosed with systemic lupus erythematosus (SLE), and yet healthcare access, utilization, and ...

    Authors: Abena A. Twumasi, Anna Shao, Charmayne Dunlop-Thomas, Cristina Drenkard and Hannah L. F. Cooper

    Citation: Arthritis Research & Therapy 2019 21:155

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  24. Content type: Research article

    Our objective was to determine the survival and causes of death in a large and well-characterized cohort of patients with giant cell arteritis (GCA).

    Authors: L. K. Brekke, B.-T. S. Fevang, A. P. Diamantopoulos, J. Assmus, E. Esperø and C. G. Gjesdal

    Citation: Arthritis Research & Therapy 2019 21:154

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  25. Content type: Research article

    Anti-malarial drug artesunate can suppress inflammation and prevent cartilage and bone destruction in collagen-induced arthritis model in rats—suggesting it may be a potent drug for rheumatoid arthritis (RA) t...

    Authors: Jian-Da Ma, Jun Jing, Jun-Wei Wang, Tao Yan, Qian-Hua Li, Ying-Qian Mo, Dong-Hui Zheng, Jin-Long Gao, Ky-Anh Nguyen and Lie Dai

    Citation: Arthritis Research & Therapy 2019 21:153

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  26. Content type: Research article

    The importance of systemic sclerosis (SSc) autoantibodies for diagnosis has become recognized by their incorporation into the 2013 ACR/EULAR classification criteria. Clear prognostic and phenotypic association...

    Authors: Claudio Corallo, Sara Cheleschi, Maurizio Cutolo, Stefano Soldano, Antonella Fioravanti, Nila Volpi, Daniela Franci, Ranuccio Nuti and Nicola Giordano

    Citation: Arthritis Research & Therapy 2019 21:152

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  27. Content type: Research article

    Tumor necrosis factor (TNF) inhibitors (TNF-i) are effective in the treatment of entero-Behcet’s disease (BD). However, there is no objective tool for assessment of disease activity in entero-BD; therefore, it...

    Authors: Ippei Miyagawa, Kazuhisa Nakano, Shigeru Iwata, Shingo Nakayamada, Kazuyoshi Saito, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Akio Kawabe, Yusuke Miyazaki and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2019 21:151

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  28. Content type: Research article

    Provisional gout remission criteria including five domains (serum urate, tophus, flares, pain due to gout, and patient global assessment) have been proposed. The aim of this study was to test the concurrent va...

    Authors: Nicola Dalbeth, Christopher Frampton, Maple Fung, Scott Baumgartner, Savvas Nicolaou and Hyon K. Choi

    Citation: Arthritis Research & Therapy 2019 21:150

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  29. Content type: Research article

    Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic an...

    Authors: Colin Shepherd, Abigail E. Reese, Louise N. Reynard and John Loughlin

    Citation: Arthritis Research & Therapy 2019 21:149

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  30. Content type: Research article

    Sensory disturbances in fibromyalgia extend beyond nociception. It has been proposed that imbalance in the mutual competition between painful input and non-painful sensory activity may, to a significant extent...

    Authors: Jesus Pujol, Daniel Ramos-López, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort and Joan Deus

    Citation: Arthritis Research & Therapy 2019 21:148

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  31. Content type: Research article

    To investigate the relationships between interferon alpha (IFNα) and the clinical and serological phenotype of patients with systemic autoimmune rheumatic disease (SARDs) in order to determine whether a distin...

    Authors: John A. Reynolds, Tracy A. Briggs, Gillian I. Rice, Sathya Darmalinggam, Vincent Bondet, Ellen Bruce, Mumtaz Khan, Sahena Haque, Hector Chinoy, Ariane L. Herrick, Eoghan M. McCarthy, Leo Zeef, Andrew Hayes, Darragh Duffy, Ben Parker and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2019 21:147

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  32. Content type: Research article

    Obesity is a leading risk factor for osteoarthritis (OA). In contrast, calorie restriction (CR) may lessen OA due to improved systemic inflammatory status and reduced weight-bearing. The aim of this study was ...

    Authors: Lauren B. Radakovich, Angela J. Marolf, Lauren A. Culver and Kelly S. Santangelo

    Citation: Arthritis Research & Therapy 2019 21:145

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  33. Content type: Research article

    Activin A and follistatin exhibit immunomodulatory functions, thus affecting autoinflammatory processes as found in rheumatoid arthritis (RA). The impact of both proteins on the behavior of synovial fibroblast...

    Authors: Magnus Diller, Klaus Frommer, Berno Dankbar, Ingo Tarner, Marie-Lisa Hülser, Lali Tsiklauri, Rebecca Hasseli, Michael Sauerbier, Thomas Pap, Stefan Rehart, Ulf Müller-Ladner and Elena Neumann

    Citation: Arthritis Research & Therapy 2019 21:144

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  34. Content type: Research article

    Most therapies for autoimmune and inflammatory diseases either neutralize or suppress production of inflammatory cytokines produced by activated macrophages (e.g., TNFα, IL-1, IL-6, IL-17, GM-CSF). However, no...

    Authors: Yingwen Hu, Bingbing Wang, Jiayin Shen, Stewart A. Low, Karson S. Putt, Hans W. M. Niessen, Eric L. Matteson, Linda Murphy, Clemens Ruppert, Gerrit Jansen, Stephen J. Oliver, Yang Feng, Dimiter S. Dimitrov, Cheryl Nickerson-Nutter and Philip S. Low

    Citation: Arthritis Research & Therapy 2019 21:143

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  35. Content type: Research article

    The aim of this study was to compare radiographic progression in patients with ankylosing spondylitis (AS) treated for up to 2 years with secukinumab (MEASURE 1) with a historical cohort of biologic-naïve pati...

    Authors: J. Braun, H. Haibel, M. de Hooge, R. Landewé, M. Rudwaleit, T. Fox, A. Readie, H. B. Richards, B. Porter, R. Martin, D. Poddubnyy, J. Sieper and D. van der Heijde

    Citation: Arthritis Research & Therapy 2019 21:142

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  36. Content type: Research article

    To assess the risks of malignancies, infections and autoimmune diseases in patients with rheumatoid arthritis (RA) treated with abatacept compared with other biologic (b) disease-modifying antirheumatic drugs ...

    Authors: Gulsen Ozen, Sofia Pedro, Rebecca Schumacher, Teresa A. Simon and Kaleb Michaud

    Citation: Arthritis Research & Therapy 2019 21:141

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  37. Content type: Research article

    To describe the disease course of patients with early arthritis without rheumatoid factor (RF) and anti-citrullinated protein auto-antibodies (ACPA) in an inception cohort. To determine baseline predictors of ...

    Authors: Gaël Mouterde, Nathalie Rincheval, Cédric Lukas, Claire Daien, Alain Saraux, Philippe Dieudé, Jacques Morel and Bernard Combe

    Citation: Arthritis Research & Therapy 2019 21:140

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  38. Content type: Research article

    (a) To describe the prevalence and incidence of peripheral arthritis during 5 years of follow-up in recent axial spondyloarthritis (axSpA), (b) to evaluate factors associated with their appearance and (c) to a...

    Authors: Clementina López-Medina, Maxime Dougados, Adeline Ruyssen-Witrand and Anna Moltó

    Citation: Arthritis Research & Therapy 2019 21:139

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  39. Content type: Research article

    Treatment persistence is an important consideration when selecting a therapy for chronic conditions such as rheumatoid arthritis (RA). We assessed the long-term persistence of abatacept or a tumor necrosis fac...

    Authors: Denis Choquette, Louis Bessette, Evo Alemao, Boulos Haraoui, Roelien Postema, Jean-Pierre Raynauld and Louis Coupal

    Citation: Arthritis Research & Therapy 2019 21:138

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  40. Content type: Research article

    Haploinsufficiency of A20 (HA20) is caused by loss-of-function TNFAIP3 variants. Phenotypic and genetic features of HA20 remain uncertain; therefore, the clinical distinction between HA20 and Behçet’s disease (BD...

    Authors: Naomi Tsuchida, Yohei Kirino, Yutaro Soejima, Masafumi Onodera, Katsuhiro Arai, Eiichiro Tamura, Takashi Ishikawa, Toshinao Kawai, Toru Uchiyama, Shigeru Nomura, Daisuke Kobayashi, Masataka Taguri, Satomi Mitsuhashi, Takeshi Mizuguchi, Atsushi Takata, Noriko Miyake…

    Citation: Arthritis Research & Therapy 2019 21:137

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  41. Content type: Research article

    Activated T and B cells participate in the development and progression of Sjögren’s syndrome (SS). Metformin, a first-line anti-diabetic drug, exerts anti-inflammatory and immunomodulatory effects by activatin...

    Authors: Ji-Won Kim, Sung-Min Kim, Jin-Sil Park, Sun-Hee Hwang, JeongWon Choi, Kyung-Ah Jung, Jun-Geol Ryu, Seon-Yeong Lee, Seung-Ki Kwok, Mi-La Cho and Sung-Hwan Park

    Citation: Arthritis Research & Therapy 2019 21:136

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  42. Content type: Review

    The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have p...

    Authors: Daniel E. Furst and James S. Louie

    Citation: Arthritis Research & Therapy 2019 21:135

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  43. Content type: Research article

    We previously found that high-mobility group box protein 1 (HMGB1) promoted cell proliferation, migration, invasion, and autophagy in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), but little is k...

    Authors: Yongsong Cai, Congshan Jiang, Jialin Zhu, Ke Xu, Xiaoyu Ren, Lin Xu, Peijing Hu, Bo Wang, Qiling Yuan, Yuanxu Guo, Jian Sun, Peng Xu and Yusheng Qiu

    Citation: Arthritis Research & Therapy 2019 21:134

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  44. Content type: Review

    Advances in genomic technology have enabled a greater understanding of the genetics of common immune-mediated diseases such as ankylosing spondylitis (AS), inflammatory bowel disease (IBD) and psoriasis. The s...

    Authors: Jessica M. Whyte, Jonathan J. Ellis, Matthew A. Brown and Tony J. Kenna

    Citation: Arthritis Research & Therapy 2019 21:133

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  45. Content type: Research article

    There is a paucity of community-based data regarding the prevalence and impact of gout flares as these may often be self-managed. The aim of this study was to determine the prevalence of self-reported gout and...

    Authors: Charlotte Proudman, Susan E. Lester, David A. Gonzalez-Chica, Tiffany K. Gill, Nicola Dalbeth and Catherine L. Hill

    Citation: Arthritis Research & Therapy 2019 21:132

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  46. Content type: Research

    Peripheral T cell lymphopenia is a clinical phenomenon in some patients with dermatomyositis (DM). Patients with T cell lymphopenia are more susceptible to life-threatening infections. However, the pathogenesi...

    Authors: Lu Zhang, Qisheng Xia, Wenli Li, Qinglin Peng, Hanbo Yang, Xin Lu and Guochun Wang

    Citation: Arthritis Research & Therapy 2019 21:131

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  47. Content type: Research article

    Sandoz etanercept (SDZ ETN; GP2015) is an etanercept biosimilar with equivalent efficacy and comparable safety and immunogenicity to reference etanercept (ETN) in patients with moderate-to-severe chronic plaqu...

    Authors: Janusz Jaworski, Marco Matucci-Cerinic, Hendrik Schulze-Koops, Maya H. Buch, Eugeniusz J. Kucharz, Yannick Allanore, Arthur Kavanaugh, Philip Young and Goran Babic

    Citation: Arthritis Research & Therapy 2019 21:130

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  48. Content type: Research article

    Previous studies have shown the relationship between higher skin thickness score and the existence of organ involvements in systemic sclerosis (SSc). Here, we firstly investigated the correlation between skin ...

    Authors: Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Shunsuke Miura, Tetsuo Toyama, Asako Yoshizaki, Hayakazu Sumida, Yoshihide Asano, Koji Oba and Shinichi Sato

    Citation: Arthritis Research & Therapy 2019 21:129

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  49. Content type: Research article

    There is substantial evidence that patients with ankylosing spondylitis (AS) have high response rates to tumour necrosis factor inhibitors (TNFi), a low likelihood of successful treatment termination, but yet ...

    Authors: Ulf Lindström, Tor Olofsson, Sara Wedrén, Ilia Qirjazo and Johan Askling

    Citation: Arthritis Research & Therapy 2019 21:128

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