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  1. Content type: Research article

    Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, bo...

    Authors: Zhihua Han, Jiandong Wang, Liang Gao, Qiugen Wang and Jianhong Wu

    Citation: Arthritis Research & Therapy 2018 20:182

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  2. Content type: Research article

    Given the need for early detection of organ involvement in systemic sclerosis, we evaluated 99mTc-rhAnnexin V-128 for the detection of early stages of interstitial lung disease (ILD) in respective animal models u...

    Authors: Janine Schniering, Li Guo, Matthias Brunner, Roger Schibli, Shuang Ye, Oliver Distler, Martin Béhé and Britta Maurer

    Citation: Arthritis Research & Therapy 2018 20:183

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  3. Content type: Research article

    Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic diagnostic biomarker for SSc-PAH would allow for ...

    Authors: Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber and Robert Layfatis

    Citation: Arthritis Research & Therapy 2018 20:185

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  4. Content type: Research article

    Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional...

    Authors: Xia Xie, Yuqing Song, Hui Yang, Anliu Nie, Hong Chen and Ji-ping Li

    Citation: Arthritis Research & Therapy 2018 20:184

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  5. Content type: Research article

    Thickened skin is a major clinical feature in patients with systemic sclerosis (SSc). We investigated changes of skin thickness in patients with SSc using both high frequency ultrasound (HFU) and the modified ...

    Authors: Hongyan Li, Daniel E. Furst, Hongtao Jin, Chao Sun, Xiaoping Wang, Lin Yang, Jingjing He, Yanru Wang and Aijing Liu

    Citation: Arthritis Research & Therapy 2018 20:181

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  6. Content type: Research article

    Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this study was to further explore the relationship between ...

    Authors: Tahzeeb Fatima, Cushla McKinney, Tanya J. Major, Lisa K. Stamp, Nicola Dalbeth, Cory Iverson, Tony R. Merriman and Jeffrey N. Miner

    Citation: Arthritis Research & Therapy 2018 20:179

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  7. Content type: Research article

    It is currently impossible to predict the prognosis of patients with juvenile dermatomyositis (JDM). The aim of this study was to find clinical features most strongly associated with outcome variables in JDM a...

    Authors: E. H. Pieter van Dijkhuizen, Maria De Iorio, Lucy R. Wedderburn and Claire T. Deakin

    Citation: Arthritis Research & Therapy 2018 20:180

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  8. Content type: Research article

    This double-blind, randomized, 78-week study evaluated the efficacy, safety, immunogenicity, pharmacokinetics, and pharmacodynamics of PF-06410293, a candidate adalimumab biosimilar, versus adalimumab referenc...

    Authors: Roy M. Fleischmann, Rieke Alten, Margarita Pileckyte, Kasia Lobello, Steven Y. Hua, Carol Cronenberger, Daniel Alvarez, Amy E. Bock and K. Lea Sewell

    Citation: Arthritis Research & Therapy 2018 20:178

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  9. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that 2 authors were erroneously mentioned as co-first authors

    Authors: Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi and Jingguo Zhou

    Citation: Arthritis Research & Therapy 2018 20:177

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    The original article was published in Arthritis Research & Therapy 2018 20:144

  10. Content type: Research article

    Patients with SLE display marked clinical and immunlogical heterogeneity. The purpose of the study was to investigate patterns of serum cytokines in patients with active and stable systemic lupus erythematosus...

    Authors: John A. Reynolds, Eoghan M. McCarthy, Sahena Haque, Pintip Ngamjanyaporn, Jamie C. Sergeant, Elaine Lee, Eileen Lee, Stephen A. Kilfeather, Ben Parker and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2018 20:173

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  11. Content type: Research article

    In the present study, we explored the effects of immediate induction therapy with the anti-tumour necrosis factor (TNF)α antibody infliximab (IFX) plus methotrexate (MTX) compared with MTX alone and with place...

    Authors: Tanja Alexandra Stamm, Klaus Peter Machold, Daniel Aletaha, Farideh Alasti, Peter Lipsky, David Pisetsky, Robert Landewe, Desiree van der Heijde, Alexandre Sepriano, Martin Aringer, Dimitri Boumpas, Gerd Burmester, Maurizio Cutolo, Wolfgang Ebner, Winfried Graninger, Tom Huizinga…

    Citation: Arthritis Research & Therapy 2018 20:174

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  12. Content type: Research article

    The Mediterranean diet has been associated with lower mortality and lower risk of cardiovascular diseases and cancer. Although its components have been analysed in several studies, only one study has specifica...

    Authors: Kari Johansson, Johan Askling, Lars Alfredsson and Daniela Di Giuseppe

    Citation: Arthritis Research & Therapy 2018 20:175

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  13. Content type: Research article

    The close temporal association between onset of some connective tissue diseases and cancer suggests a paraneoplastic association. Adult patients with scleroderma with anti-RNA polymerase III autoantibodies and...

    Authors: Zoe E. Betteridge, Lynsey Priest, Robert G. Cooper, Neil J. McHugh, Fiona Blackhall and Janine A. Lamb

    Citation: Arthritis Research & Therapy 2018 20:176

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  14. Content type: Research article

    The aim of this study was to measure the association between exposure to commonly used oral osteoarthritis (OA) therapies and relevant confounding risk factors on the occurrence of knee replacement (KR), using...

    Authors: Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme and Jean-Pierre Pelletier

    Citation: Arthritis Research & Therapy 2018 20:172

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  15. Content type: Research article

    Inflammatory arthritides including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are associated with increased risk of cardiovascular disease. This process may be driven ...

    Authors: Joshua L. Lee, Premarani Sinnathurai, Rachelle Buchbinder, Catherine Hill, Marissa Lassere and Lyn March

    Citation: Arthritis Research & Therapy 2018 20:171

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  16. Content type: Research article

    To examine the activity of the mammalian target of rapamycin (mTOR) pathway and its regulators, transforming growth factor (TGF)-β1 and phosphatase and tensin homolog (PTEN), in minor salivary gland biopsies o...

    Authors: Zeki Soypaçacı, Zeynep Zehra Gümüş, Fulya Çakaloğlu, Mustafa Özmen, Dilek Solmaz, Sercan Gücenmez, Önay Gercik and Servet Akar

    Citation: Arthritis Research & Therapy 2018 20:170

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  17. Content type: Research article

    Clinical remission can be maintained after the discontinuation of biological disease-modifying antirheumatic drugs (bDMARDs) in some patients with rheumatoid arthritis (RA) (bDMARD-free remission (BFR)). It is...

    Authors: Motomu Hashimoto, Moritoshi Furu, Wararu Yamamoto, Takanori Fujimura, Ryota Hara, Masaki Katayama, Akira Ohnishi, Kengo Akashi, Shuzo Yoshida, Koji Nagai, Yonsu Son, Hideki Amuro, Toru Hirano, Kosuke Ebina, Ryuji Uozumi, Hiromu Ito…

    Citation: Arthritis Research & Therapy 2018 20:165

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  18. Content type: Research article

    Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease. The dysregulated immune system plays an important role in the pathogenesis of AS. Myeloid-derived suppressor cells (MDSCs) play a key im...

    Authors: Yu-feng Liu, Kun-hai Zhuang, Bin Chen, Pei-wu Li, Xuan Zhou, Hua Jiang, Li-mei Zhong and Feng-bin Liu

    Citation: Arthritis Research & Therapy 2018 20:168

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  19. Content type: Research article

    The aim of this study was to investigate the regulatory role of G-protein coupled receptor 120 (GPR120) in the development and progression of osteoarthritis (OA).

    Authors: Yuanfeng Chen, Dan Zhang, Ki Wai Ho, Sien Lin, Wade Chun-Wai Suen, Huantian Zhang, Zhengang Zha, Gang Li and Po Sing Leung

    Citation: Arthritis Research & Therapy 2018 20:163

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  20. Content type: Research article

    Knowledge about predictors of new spinal bone formation in patients with ankylosing spondylitis (AS) is limited. AS-related spinal alterations are more common in men; however, knowledge of whether predictors d...

    Authors: Anna Deminger, Eva Klingberg, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson and Helena Forsblad-d’Elia

    Citation: Arthritis Research & Therapy 2018 20:162

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  21. Content type: Research article

    Metabolomics is an emerging field of biomedical research that may offer a better understanding of the mechanisms of underlying conditions including inflammatory arthritis. Perturbations caused by inflamed syno...

    Authors: Rekha Narasimhan, Roxana Coras, Sara B. Rosenthal, Shannon R. Sweeney, Alessia Lodi, Stefano Tiziani, David Boyle, Arthur Kavanaugh and Monica Guma

    Citation: Arthritis Research & Therapy 2018 20:164

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  22. Content type: Research article

    Activation of the NLRP3 inflammasome in gout amplifies the inflammatory response and mediates further damage. In the current study, we assessed the therapeutic effect of OLT1177, an orally active NLRP3 inflamm...

    Authors: Carlo Marchetti, Benjamin Swartzwelter, Marije I. Koenders, Tania Azam, Isak W. Tengesdal, Nick Powers, Dennis M. de Graaf, Charles A. Dinarello and Leo A. B. Joosten

    Citation: Arthritis Research & Therapy 2018 20:169

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  23. Content type: Research article

    The Assessment of SpondyloArthritis international Society (ASAS) defines a positive family history (PFH) of spondyloarthritis (SpA) as the presence of ankylosing spondylitis (AS), acute anterior uveitis (AAU),...

    Authors: Miranda van Lunteren, Alexandre Sepriano, Robert Landewé, Joachim Sieper, Martin Rudwaleit, Désirée van der Heijde and Floris van Gaalen

    Citation: Arthritis Research & Therapy 2018 20:166

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  24. Content type: Research article

    Over the last decade, a treat-to-target (T2T) strategy has been recommended for psoriatic arthritis (PsA) and new treatment options have become available. There is a lack of data on PsA regarding any changes t...

    Authors: Glenn Haugeberg, Brigitte Michelsen, Stig Tengesdal, Inger Johanne Widding Hansen, Andreas Diamantopoulos and Arthur Kavanaugh

    Citation: Arthritis Research & Therapy 2018 20:160

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  25. Content type: Research article

    We recently demonstrated that BATF, a member of the activator protein-1 (AP-1) family, regulates osteoarthritic cartilage destruction. Here, we explored the roles and regulatory mechanisms of BATF in collagen-...

    Authors: Sang-Heon Park, Jinseol Rhee, Seul-Ki Kim, Jung-Ah Kang, Ji-Sun Kwak, Young-Ok Son, Wan-Su Choi, Sung-Gyoo Park and Jang-Soo Chun

    Citation: Arthritis Research & Therapy 2018 20:161

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  26. Content type: Research article

    To examine the expression of ADAM-17 in rheumatoid arthritis (RA) biological fluids and the role it plays in monocyte adhesion to RA fibroblast-like synoviocytes (FLSs).

    Authors: Sho Ishii, Takeo Isozaki, Hidekazu Furuya, Hiroko Takeuchi, Yumi Tsubokura, Katsunori Inagaki and Tsuyoshi Kasama

    Citation: Arthritis Research & Therapy 2018 20:159

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  27. Content type: Research article

    The molecular heterogeneity of autoimmune and inflammatory diseases has been one of the main obstacles to the development of safe and specific therapeutic options. Here, we evaluated the diagnostic and clinica...

    Authors: João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd and Ricardo C. Ferreira

    Citation: Arthritis Research & Therapy 2018 20:152

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  28. Content type: Research article

    Although the effects of interleukin-17A (IL-17A) inhibition on the signs and symptoms of psoriatic arthritis (PsA) are well defined, little is known about its impact of local inflammatory and structural change...

    Authors: Eleni Kampylafka, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Fabian Stemmler, David Simon, Matthias Englbrecht, Michael Sticherling, Jürgen Rech, Arnd Kleyer, Georg Schett and Axel J. Hueber

    Citation: Arthritis Research & Therapy 2018 20:153

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  29. Content type: Research article

    This double-blind, active-controlled, randomized, multinational study evaluated the efficacy, safety, pharmacokinetics (PK), and immunogenicity of PF-06438179/GP1111 (IxifiTM/Zessly®), an infliximab biosimilar...

    Authors: Stanley B. Cohen, Rieke Alten, Hideto Kameda, Tomas Hala, Sebastiao C. Radominski, Muhammad I. Rehman, Ramesh Palaparthy, Karl Schumacher, Susanne Schmitt, Steven Y. Hua, Claudia Ianos and K. Lea Sewell

    Citation: Arthritis Research & Therapy 2018 20:155

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  30. Content type: Research article

    B-cell activating factor of the tumour necrosis factor family (BAFF) plays a role in autoantibody production and is elevated in dermatomyositis (DM) and anti-Jo-1-positive polymyositis (PM). We investigated th...

    Authors: Olga Kryštůfková, Hana Hulejová, Heřman F. Mann, Ondřej Pecha, Ivana Půtová, Louise Ekholm, Ingrid E. Lundberg and Jiří Vencovský

    Citation: Arthritis Research & Therapy 2018 20:158

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  31. Content type: Research article

    Systemic sclerosis (SSc) is characterized by vasculopathy and progressive fibrosis. CTLA4-Ig (abatacept) is able to interact with the cell surface costimulatory molecule CD86 and downregulate the target cell. ...

    Authors: Maurizio Cutolo, Stefano Soldano, Paola Montagna, Amelia Chiara Trombetta, Paola Contini, Barbara Ruaro, Alberto Sulli, Stefano Scabini, Emanuela Stratta, Sabrina Paolino, Carmen Pizzorni, Vanessa Smith and Renata Brizzolara

    Citation: Arthritis Research & Therapy 2018 20:157

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  32. Content type: Research article

    There is a remarkable lack of detailed knowledge on pain areas in axial spondyloarthritis (axSpA), and their clinical relevance is largely unknown. Pain area may reflect local disease processes, but amplificat...

    Authors: Thijs Willem Swinnen, René Westhovens, Wim Dankaerts and Kurt de Vlam

    Citation: Arthritis Research & Therapy 2018 20:156

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  33. Content type: Research article

    Pain accompanies rheumatoid arthritis and other chronic inflammatory conditions and is difficult to manage. Although opioids provide potent analgesia, chronic opioid use can cause tolerance and addiction. Rece...

    Authors: Raini Dutta, Mary M. Lunzer, Jennifer L. Auger, Eyup Akgün, Philip S. Portoghese and Bryce A. Binstadt

    Citation: Arthritis Research & Therapy 2018 20:154

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  34. Content type: Research article

    Following the onset of rheumatoid arthritis (RA), patients experience a functional decline caused by various joint symptoms which affects their activities of daily living and can lead to reduced work productiv...

    Authors: Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda and Hitoshi Kohsaka

    Citation: Arthritis Research & Therapy 2018 20:151

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  35. Content type: Research article

    Dysbiosis occurs in spondyloarthritis (SpA) and inflammatory bowel disease (IBD), which is subdivided into Crohn’s disease (CD) and ulcerative colitis (UC). The immunologic consequences of alterations in micro...

    Authors: Emilie H. Regner, Neha Ohri, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Diana Ir, Widian K. Jubair, Carsten Görg, Janet Siebert, Charles E. Robertson, Liron Caplan, Daniel N. Frank and Kristine A. Kuhn

    Citation: Arthritis Research & Therapy 2018 20:149

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  36. Content type: Research article

    It is not known if sex-based disparities in immunological factors contribute to the disease process in rheumatoid arthritis (RA). Hence, we examined whether circulating T cell subset proportions and their asso...

    Authors: Jonathan Aldridge, Jayesh M. Pandya, Linda Meurs, Kerstin Andersson, Inger Nordström, Elke Theander, Anna-Carin Lundell and Anna Rudin

    Citation: Arthritis Research & Therapy 2018 20:150

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  37. Content type: Research article

    Histone deacetylase inhibitors (HDACi) suppress cytokine production in immune and stromal cells of patients with rheumatoid arthritis (RA). Here, we investigated the effects of the HDACi givinostat (ITF2357) o...

    Authors: Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten and Timothy R. D. J. Radstake

    Citation: Arthritis Research & Therapy 2018 20:148

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  38. Content type: Research article

    Anti-citrullinated protein antibody (ACPA) reactivities precede clinical onset of rheumatoid arthritis (RA), and it has been suggested that ACPA reactivities towards distinct target proteins may be associated ...

    Authors: Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina and Espen Andre Haavardsholm

    Citation: Arthritis Research & Therapy 2018 20:146

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  39. Content type: Research article

    Methotrexate (MTX) remains the disease-modifying anti-rheumatic drug of first choice in rheumatoid arthritis (RA) but response varies. Predicting non-response to MTX could enable earlier access to alternative ...

    Authors: Jamie C. Sergeant, Kimme L. Hyrich, James Anderson, Kamilla Kopec-Harding, Holly F. Hope, Deborah P. M. Symmons, Anne Barton and Suzanne M. M. Verstappen

    Citation: Arthritis Research & Therapy 2018 20:147

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  40. Content type: Research article

    We aimed to evaluate the diagnostic utility of pelvic radiographs versus magnetic resonance imaging (MRI) of the sacroiliac joints in children with suspected sacroiliitis.

    Authors: Pamela F. Weiss, Rui Xiao, Timothy G. Brandon, David M. Biko, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko and Nancy A. Chauvin

    Citation: Arthritis Research & Therapy 2018 20:141

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  41. Content type: Research article

    Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership...

    Authors: Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure…

    Citation: Arthritis Research & Therapy 2018 20:139

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  42. Content type: Research article

    Monocyte-derived dendritic cells (moDCs) play important roles in the pathogenesis of systemic lupus erythematosus (SLE). Aberrant expression of long noncoding RNAs (lncRNAs) could affect the function of moDCs....

    Authors: Yilun Wang, Shuang Chen, Sunyi Chen, Juan Du, Jinran Lin, Haihong Qin, Jie Wang, Jun Liang and Jinhua Xu

    Citation: Arthritis Research & Therapy 2018 20:138

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  43. Content type: Research article

    A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator ...

    Authors: Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte and John Varga

    Citation: Arthritis Research & Therapy 2018 20:145

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  44. Content type: Research article

    Gout has an increasing global prevalence. Underutilization of urate-lowering therapy (ULT) is thought to be common, via both suboptimal dosing and poor medication adherence. The aims of this study were to dete...

    Authors: Huai Leng Pisaniello, Susan Lester, David Gonzalez-Chica, Nigel Stocks, Marie Longo, Greg R. Sharplin, Eleonora Dal Grande, Tiffany K. Gill, Samuel L. Whittle and Catherine L. Hill

    Citation: Arthritis Research & Therapy 2018 20:143

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  45. Content type: Review

    Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axS...

    Authors: Sizheng Zhao, Daniel Thong, Natasha Miller, Stephen J. Duffield, David M. Hughes, Laura Chadwick and Nicola J. Goodson

    Citation: Arthritis Research & Therapy 2018 20:140

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  46. Content type: Research article

    The findings of a previous study by Jin et al. have shown that microRNA (miR)-155 was upregulated in patients with acute gouty arthritis and enhanced the proinflammatory cytokines. There is no direct evidence ...

    Authors: Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi and Jingguo Zhou

    Citation: Arthritis Research & Therapy 2018 20:144

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:177

  47. Content type: Research article

    Takayasu arteritis (TAK) is a systemic disease characterized by large vessel involvement. Although the vascular characteristics of TAK are well characterized, there is no well-organized study demonstrating the...

    Authors: Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo and Yong-Gil Kim

    Citation: Arthritis Research & Therapy 2018 20:142

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  48. Content type: Research article

    Accumulating evidence implicates mitochondrial DNA (mtDNA) alleles, which are independent of the nuclear genome, in disease, especially in human metabolic diseases. However, this area of investigation has lagg...

    Authors: Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang and Wei-Ting Liao

    Citation: Arthritis Research & Therapy 2018 20:137

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  49. Content type: Research article

    Hydroxychloroquine (HCQ) retinopathy may be more common than previously recognized; recent ophthalmology guidelines have revised recommendations from ideal body weight (IBW)-based dosing to actual body weight ...

    Authors: April M. Jorge, Ronald B. Melles, Yuqing Zhang, Na Lu, Sharan K. Rai, Lucy H. Young, Karen H. Costenbader, Rosalind Ramsey-Goldman, S. Sam Lim, John M. Esdaile, Ann E. Clarke, M. B. Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri and Hyon Choi

    Citation: Arthritis Research & Therapy 2018 20:133

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