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  1. Content type: Research article

    Neutrophil extracellular trap (NET) formation has been described to be closely involved in the pathogenesis of systemic lupus erythematosus (SLE). In this study, we aimed to investigate the effect of polydatin...

    Authors: Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng and Erwei Sun

    Citation: Arthritis Research & Therapy 2018 20:254

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  2. Content type: Research article

    Varicella zoster virus (VZV)-specific cellular immunity is essential for viral control, and the incidence of VZV reactivation is increased in patients with rheumatic diseases. Because knowledge of the influenc...

    Authors: David Schub, Gunter Assmann, Urban Sester, Martina Sester and Tina Schmidt

    Citation: Arthritis Research & Therapy 2018 20:252

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  3. Content type: Research article

    Evidence for non-pharmacological interventions in hand osteoarthritis is promising but still scarce. Combined interventions are most likely to best cover the clinical needs of patients with hand osteoarthritis...

    Authors: Michaela A. Stoffer-Marx, Meike Klinger, Simone Luschin, Silvia Meriaux-Kratochvila, Monika Zettel-Tomenendal, Valerie Nell-Duxneuner, Jochen Zwerina, Ingvild Kjeken, Marion Hackl, Sylvia Öhlinger, Anthony Woolf, Kurt Redlich, Josef S. Smolen and Tanja A. Stamm

    Citation: Arthritis Research & Therapy 2018 20:253

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  4. Content type: Review

    Lumbar disc herniation (LDH) is highly associated with inflammation in the context of low back pain. Currently, inflammation is associated with adverse symptoms related to the stimulation of nerve fibers that ...

    Authors: Carla Cunha, Ana J. Silva, Paulo Pereira, Rui Vaz, Raquel M. Gonçalves and Mário A. Barbosa

    Citation: Arthritis Research & Therapy 2018 20:251

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  5. Content type: Research article

    There is evidence that knee pain not only is a consequence of structural deterioration in osteoarthritis (OA) but also contributes to structural progression. Clarifying this is important because targeting the ...

    Authors: Yuanyuan Wang, Andrew J. Teichtahl, François Abram, Sultana Monira Hussain, Jean-Pierre Pelletier, Flavia M. Cicuttini and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2018 20:250

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  6. Content type: Research article

    Although one of the three obstetric manifestations of antiphospholipid syndrome (APS) is intrauterine fetal death (IUFD), little is known about it in this context. We report the first large series of patients ...

    Authors: Mériem Belhocine, Laetitia Coutte, Nicolas Martin Silva, Nathalie Morel, Gaëlle Guettrot-Imbert, Romain Paule, Claire Le Jeunne, Micaela Fredi, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Vassilis Tsatsaris, Emmanuelle Pannier, Véronique Le Guern and Nathalie Costedoat-Chalumeau

    Citation: Arthritis Research & Therapy 2018 20:249

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  7. Content type: Correction

    Following publication of the original article [1], the authors reported a typesetting error.

    Authors: Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti and Ombretta Viapiana

    Citation: Arthritis Research & Therapy 2018 20:248

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    The original article was published in Arthritis Research & Therapy 2018 20:233

  8. Content type: Research article

    Epidemiological evidence to suggest that periodontal disease (PD) is involved in the progression of rheumatoid arthritis (RA) is increasing. The complement system plays a critical role in immune responses. C5a...

    Authors: Syuichi Munenaga, Kazuhisa Ouhara, Yuta Hamamoto, Mikihito Kajiya, Katsuhiro Takeda, Satoshi Yamasaki, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama and Hidemi Kurihara

    Citation: Arthritis Research & Therapy 2018 20:247

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  9. Content type: Research article

    Our aim was to investigate dynamic changes in hepatitis B virus (HBV) surface antibody (HBsAb) titer and the associated risk of HBV reactivation and clinical course in patients with HBV surface antigen negativ...

    Authors: Ya-Chih Tien, Hsu-Heng Yen, Ching-Fang Li, Mei-Ping Liu, Yin-Tzu Hsue, Ming-Hui Hung and Ying-Ming Chiu

    Citation: Arthritis Research & Therapy 2018 20:246

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  10. Content type: Research article

    Rheumatoid arthritis (RA) knowledge has been constructed with studies performed in Caucasians patients; Latin American patients present unique characteristics. Empowerment is a social multidimensional construc...

    Authors: Irazú Contreras-Yáñez, Emmanuel Ruiz-Medrano, Luz del Carmen R. Hernández and Virginia Pascual-Ramos

    Citation: Arthritis Research & Therapy 2018 20:244

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  11. Content type: Research article

    An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lower...

    Authors: Matthew Roughley, Alyshah Abdul Sultan, Lorna Clarson, Sara Muller, Rebecca Whittle, John Belcher, Christian D. Mallen and Edward Roddy

    Citation: Arthritis Research & Therapy 2018 20:243

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  12. Content type: Research article

    Different adiponectin isoforms appear to be differentially involved in the pathogenesis of various diseases. The purpose of this study was to generate monoclonal antibodies (mAbs) specific to different adipone...

    Authors: Yeon-Ah Lee, Dae-Hyun Hahm, Jung Yeon Kim, Bonjun Sur, Hyun Min Lee, Chun Jeih Ryu, Hyung-In Yang and Kyoung Soo Kim

    Citation: Arthritis Research & Therapy 2018 20:245

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  13. Content type: Research article

    The multiple disease domains affected in psoriatic arthritis (PsA) may make composite endpoints appropriate for assessing changes in disease activity over time. Tofacitinib is an oral Janus kinase inhibitor fo...

    Authors: Philip Helliwell, Laura C. Coates, Oliver FitzGerald, Peter Nash, Enrique R. Soriano, M. Elaine Husni, Ming-Ann Hsu, Keith S. Kanik, Thijs Hendrikx, Joseph Wu and Elizabeth Kudlacz

    Citation: Arthritis Research & Therapy 2018 20:242

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  14. Content type: Research article

    Dermatomyositis (DM) with rapidly progressive interstitial lung disease (DM RP-ILD) is a life-threatening condition. Serum cytokine levels are potentially suitable biomarkers for DM RP-ILD. However, the relati...

    Authors: Yuichi Ishikawa, Shigeru Iwata, Kentaro Hanami, Aya Nawata, Mingzeng Zhang, Kaoru Yamagata, Shintaro Hirata, Kei Sakata, Yasuyuki Todoroki, Kazuhisa Nakano, Shingo Nakayamada, Minoru Satoh and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2018 20:240

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  15. Content type: Research article

    Nailfold capillaroscopy (NC) is an important tool for the diagnosis of systemic sclerosis (SSc). The capillaroscopic skin ulcer risk index (CSURI) was suggested to identify patients at risk of developing digit...

    Authors: Ulrich A. Walker, Veronika K. Jaeger, Katharina M. Bruppacher, Rucsandra Dobrota, Lionel Arlettaz, Martin Banyai, Jörg Beron, Carlo Chizzolini, Ernst Groechenig, Rüdiger B. Mueller, François Spertini, Peter M. Villiger and Oliver Distler

    Citation: Arthritis Research & Therapy 2018 20:239

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  16. Content type: Research article

    In systemic lupus erythematosus (SLE), immune complexes (ICs) containing self-derived nucleic acids trigger the synthesis of proinflammatory cytokines by immune cells. We asked how an interleukin (IL)-1 recept...

    Authors: Karin Hjorton, Niklas Hagberg, Elisabeth Israelsson, Lisa Jinton, Olof Berggren, Johanna K. Sandling, Kristofer Thörn, John Mo, Maija-Leena Eloranta and Lars Rönnblom

    Citation: Arthritis Research & Therapy 2018 20:238

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  17. Content type: Research article

    The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-...

    Authors: Zhaohua Zhu, Changhai Ding, Weiyu Han, Shuang Zheng, Tania Winzenberg, Flavia Cicuttini and Graeme Jones

    Citation: Arthritis Research & Therapy 2018 20:237

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  18. Content type: Research article

    We aimed to evaluate the phenotype, function, and microRNA (miRNA)17–92 cluster expression in Vγ9Vδ2 T-cell subsets and the correlation with immune response in rheumatoid arthritis (RA) patients.

    Authors: Giuliana Guggino, Valentina Orlando, Laura Saieva, Piero Ruscitti, Paola Cipriani, Marco Pio La Manna, Roberto Giacomelli, Riccardo Alessandro, Giovanni Triolo, Francesco Ciccia, Francesco Dieli and Nadia Caccamo

    Citation: Arthritis Research & Therapy 2018 20:236

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  19. Content type: Research article

    Systemic sclerosis is a disease that has significant clinical heterogeneity. This study aims to determine the causes and risk factors of death in a single center European League Against Rheumatism Scleroderma ...

    Authors: Shasha Hu, Yong Hou, Qian Wang, Mengtao Li, Dong Xu and Xiaofeng Zeng

    Citation: Arthritis Research & Therapy 2018 20:235

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  20. Content type: Research article

    It is estimated that 50–70% of patients with rheumatoid arthritis (RA) are non-adherent to their recommended treatment. Non-adherent patients have a higher risk of not reaching an optimal clinical outcome. We ...

    Authors: Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor, Michaela Lehner, Maisa Omara, Romualdo Ramos, Paul Studenic, Josef Sebastian Smolen and Tanja Alexandra Stamm

    Citation: Arthritis Research & Therapy 2018 20:234

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  21. Content type: Letter

    Authors: Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti and Ombretta Viapiana

    Citation: Arthritis Research & Therapy 2018 20:233

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    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:248

    The original article was published in Arthritis Research & Therapy 2018 20:162

  22. Content type: Research article

    Obesity is a primary risk factor for the development of knee osteoarthritis (OA). However, there remains a lack of in vivo data on the influence of obesity on knee cartilage mechanics and composition. The purpose...

    Authors: Amber T Collins, Micaela L Kulvaranon, Hattie C Cutcliffe, Gangadhar M Utturkar, Wyatt A R Smith, Charles E Spritzer, Farshid Guilak and Louis E DeFrate

    Citation: Arthritis Research & Therapy 2018 20:232

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  23. Content type: Research article

    This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years.

    Authors: Hyoung Rae Kim, Yeon Sik Hong, Sung-Hwan Park, Ji Hyeon Ju and Kwi Young Kang

    Citation: Arthritis Research & Therapy 2018 20:231

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  24. Content type: Research article

    We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after tre...

    Authors: Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma and Floris P J G Lafeber

    Citation: Arthritis Research & Therapy 2018 20:230

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  25. Content type: Review

    Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseas...

    Authors: Jean-Luc Davignon, Benjamin Rauwel, Yannick Degboé, Arnaud Constantin, Jean-Fredéric Boyer, Andrey Kruglov and Alain Cantagrel

    Citation: Arthritis Research & Therapy 2018 20:229

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  26. Content type: Review

    Musculoskeletal ultrasound (US) is frequently used in several rheumatology practices to detect subclinical inflammation in patients with joint symptoms suspected for progression to inflammatory arthritis. Eval...

    Authors: Rosaline van den Berg, Sarah Ohrndorf, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2018 20:228

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  27. Content type: Research article

    Biologic therapy has changed the prognosis of patients with juvenile idiopathic arthritis (JIA). The aim of this study was to examine the pattern of use, drug survival, and adverse events of biologics in patie...

    Authors: Juan José Bethencourt Baute, Carlos Sanchez-Piedra, Dolores Ruiz-Montesinos, Marta Medrano San Ildefonso, Carlos Rodriguez-Lozano, Eva Perez-Pampin, Ana Ortiz, Sara Manrique, Rosa Roselló, Victoria Hernandez, Cristina Campos, Agustí Sellas, Walter Alberto Sifuentes-Giraldo, Javier García-González, Fernando Sanchez-Alonso, Federico Díaz-González…

    Citation: Arthritis Research & Therapy 2018 20:227

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  28. Content type: Research article

    Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. The epidemiological data on AAV in China are limited. The aim of the present stud...

    Authors: Jiannan Li, Zhao Cui, Jian-yan Long, Wei Huang, Jin-wei Wang, Haibo Wang, Luxia Zhang, Min Chen and Ming-hui Zhao

    Citation: Arthritis Research & Therapy 2018 20:226

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  29. Content type: Research article

    Expression of E2F transcription factor 2 (E2F2), a transcription factor related to the cell cycle, is abnormally high in rheumatoid arthritis synovial fibroblasts (RASFs). Deregulated expression of E2F2 leads ...

    Authors: Shiguan Wang, Lin Wang, Changshun Wu, Shui Sun and Ji-hong Pan

    Citation: Arthritis Research & Therapy 2018 20:225

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  30. Content type: Research article

    Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) actively drive joint inflammation and degradation by producing inflammatory cytokines and matrix-degrading molecules, making them key factors in the ...

    Authors: Le-meng Zhang, Jing-Jing Zhou and Chun-lei Luo

    Citation: Arthritis Research & Therapy 2018 20:219

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  31. Content type: Research article

    Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal flui...

    Authors: Dong-Jin Park, Seong-Ho Kim, Seong-Su Nah, Ji Hyun Lee, Seong-Kyu Kim, Yeon-Ah Lee, Seung-Jae Hong, Hyun-Sook Kim, Hye-Soon Lee, Hyoun Ah Kim, Chung-Il Joung, Sang-Hyon Kim and Shin-Seok Lee

    Citation: Arthritis Research & Therapy 2018 20:220

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  32. Content type: Research article

    Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-B...

    Authors: Paola Di Benedetto, Vasiliki Liakouli, Piero Ruscitti, Onorina Berardicurti, Francesco Carubbi, Noemi Panzera, Salvatore Di Bartolomeo, Giuliana Guggino, Francesco Ciccia, Giovanni Triolo, Paola Cipriani and Roberto Giacomelli

    Citation: Arthritis Research & Therapy 2018 20:223

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  33. Content type: Research article

    Immunoglobulin G4-related disease (IgG4-RD) promptly responds to glucocorticoids but relapses in a considerable fraction of patients. Reliable biomarkers of flare are currently lacking because the pathophysiol...

    Authors: Marco Lanzillotta, Emanuel Della-Torre, Raffaella Milani, Enrica Bozzolo, Emanuele Bozzalla-Cassione, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Stefano Partelli, Massimo Falconi, Fabio Ciceri and Lorenzo Dagna

    Citation: Arthritis Research & Therapy 2018 20:222

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  34. Content type: Research

    To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients.

    Authors: Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes and Pilar Font

    Citation: Arthritis Research & Therapy 2018 20:221

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  35. Content type: Research article

    To explore to what extent synovial hypertrophy in joints without Doppler activity is a sign of active disease, we investigated the sensitivity to change of synovial hypertrophy without Doppler activity during bio...

    Authors: Lene Terslev, Mikkel Østergaard, Joe Sexton and Hilde Berner Hammer

    Citation: Arthritis Research & Therapy 2018 20:224

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  36. Content type: Research article

    Although gender differences have been observed in the severity of axial spondyloarthritis (axSpA), gender differences in disease presentation of early axSpA have not been thoroughly investigated. In particular...

    Authors: Augusta Ortolan, Miranda van Lunteren, Sofia Ramiro, Roberta Ramonda, Robert B. M. Landewé, Hanne Dagfinrud, Lennart T. H. Jacobsson, Désirée van der Heijde and Floris A. van Gaalen

    Citation: Arthritis Research & Therapy 2018 20:218

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  37. Content type: Research article

    The aims of this study were to investigate the gene expression of CCN family members in rat intervertebral disc (IVD) cells and to examine whether Wnt–β-catenin signaling regulates the expression of CCN family...

    Authors: Akihiko Hiyama, Kosuke Morita, Daisuke Sakai and Masahiko Watanabe

    Citation: Arthritis Research & Therapy 2018 20:217

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  38. Content type: Research article

    Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of t...

    Authors: Gwen Sascha Fernandes, Ana Marie Valdes, David Andrew Walsh, Weiya Zhang and Michael Doherty

    Citation: Arthritis Research & Therapy 2018 20:215

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  39. Content type: Research article

    The diagnosis of Behçet’s disease (BD) remains challenging due to the lack of diagnostic biomarkers. This study aims to identify potential serum metabolites associated with BD and its disease activity.

    Authors: Wenjie Zheng, Xiuhua Wu, Maryam Goudarzi, Jing Shi, Wei Song, Chaoran Li, Jinjing Liu, Hua Chen, Xuan Zhang, Xiaofeng Zeng and Heng-Hong Li

    Citation: Arthritis Research & Therapy 2018 20:214

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  40. Content type: Research article

    A recent study found that CD177 served as a receptor of membrane-bound proteinase-3 (mPR3) in a subset of neutrophils. Furthermore, CD177 has been identified as a high-affinity heterophilic binding partner for...

    Authors: Hui Deng, Nan Hu, Chen Wang, Min Chen and Ming-Hui Zhao

    Citation: Arthritis Research & Therapy 2018 20:213

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  41. Content type: Research article

    Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeut...

    Authors: Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin and Erik Lubberts

    Citation: Arthritis Research & Therapy 2018 20:212

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  42. Content type: Research article

    In this study, the effect of 15-month anti-tumor necrosis factor alpha (TNF-α) treatment on circulating levels of plasma sulfated glycosaminoglycans (GAGs) and the nonsulfated GAG hyaluronic acid (HA) in femal...

    Authors: Anna Szeremeta, Agnieszka Jura-Półtorak, Ewa Maria Koźma, Andrzej Głowacki, Eugeniusz Józef Kucharz, Magdalena Kopeć-Mędrek and Krystyna Olczyk

    Citation: Arthritis Research & Therapy 2018 20:211

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  43. Content type: Research article

    Predicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosod...

    Authors: Tristan Pascart, Agathe Grandjean, Benoist Capon, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak and Jean-François Budzik

    Citation: Arthritis Research & Therapy 2018 20:210

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  44. Content type: Research article

    To be eligible to receive treatment with an anti-tumour necrosis factor (TNF), non-radiographic axial spondyloarthritis (nr-axSpA) patients require either elevated levels of C-reactive protein (CRP) (CRP > upp...

    Authors: Robert Landewé, Tommi Nurminen, Owen Davies and Dominique Baeten

    Citation: Arthritis Research & Therapy 2018 20:209

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  45. Content type: Research

    Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are...

    Authors: Ashika Chhana, Bregina Pool, Karen E. Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2018 20:208

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  46. Content type: Research article

    Studies on the relationship between osteoporosis and intervertebral disc degeneration (IVDD) are inconsistent. Therefore, we assessed whether IVDD is affected by vertebral osteoporosis in ovariectomized mice a...

    Authors: Zhi-feng Xiao, Jian-bo He, Guo-yi Su, Mei-hui Chen, Yu Hou, Shu-dong Chen and Ding-kun Lin

    Citation: Arthritis Research & Therapy 2018 20:207

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  47. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect.

    Authors: Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson and Mats Dehlin

    Citation: Arthritis Research & Therapy 2018 20:206

    Published on:

    The original article was published in Arthritis Research & Therapy 2018 20:108

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