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  1. The study investigated the pathogenesis of Yao syndrome (YAOS), a rare systemic autoinflammatory disease associated with the nucleotide-binding oligomerization domain containing 2 (NOD2) gene variants.

    Authors: Jingyuan Zhang, Yi Luo, Bingxuan Wu, Xin Huang, Mengzhu Zhao, Na Wu, Junke Miao, Ji Li, Lei Zhu, Di Wu and Min Shen
    Citation: Arthritis Research & Therapy 2024 26:58
  2. Patients with Rheumatoid Arthritis (RA) have a higher prevalence of comorbidities compared to the general population. However, the implications of multimorbidity on therapeutic response and treatment retention...

    Authors: Jerusalem Calvo-Gutiérrez, Clementina López-Medina, Lucía Otero-Varela, Alejandro Escudero-Contreras, Rafaela Ortega-Castro, Lourdes Ladehesa-Pineda, Cristina Campos, Pilar Bernabeu-Gonzalvez, Ana Pérez-Gómez, Alicia García-Dorta, Dolores Ruiz-Montesino, Manuel Pombo-Suarez, Inmaculada Ros-Vilamajo, Fernando Sánchez-Alonso and Isabel Castrejón
    Citation: Arthritis Research & Therapy 2024 26:57
  3. Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like synoviocytes in RA (RA-FLSs-Exos) play a role in the development of RA, and ci...

    Authors: Guoqing Li, Yuxuan Fang, Nan Xu, Yimin Ding and Dan Liu
    Citation: Arthritis Research & Therapy 2024 26:56
  4. IgG4-related disease (IgG4-RD) is a systemic autoimmune disease with an unknown etiology, affecting single/multiple organ(s). Pathological findings include the infiltration of IgG4-producing plasma cells, obli...

    Authors: Shigeru Tanaka, Takuya Yamamoto, Arifumi Iwata, Masahiro Kiuchi, Kota Kokubo, Tomohisa Iinuma, Takahiro Sugiyama, Toyoyuki Hanazawa, Kiyoshi Hirahara, Kei Ikeda and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2024 26:55
  5. Leveraging the Accelerating Medicines Partnership (AMP) Lupus Nephritis (LN) dataset, we evaluated longitudinal patterns, rates, and predictors of response to standard-of-care therapy in patients with lupus ne...

    Authors: Peter M. Izmirly, Mimi Y. Kim, Philip M. Carlucci, Katherine Preisinger, Brooke Z. Cohen, Kristina Deonaraine, Devyn Zaminski, Maria Dall’Era, Kenneth Kalunian, Andrea Fava, H. Michael Belmont, Ming Wu, Chaim Putterman, Jennifer Anolik, Jennifer L. Barnas, Betty Diamond…
    Citation: Arthritis Research & Therapy 2024 26:54
  6. Understanding of pain in osteoarthritis, its genesis, and perception is still in its early stages. Identification of precise ligand-receptor pairs that transduce pain and the cells and tissues in which they re...

    Authors: Akshay Pandey, Mamta Singla, Ana Geller, Stuart B. Goodman and Nidhi Bhutani
    Citation: Arthritis Research & Therapy 2024 26:53
  7. Henoch–Schönlein purpura (HSP) is the most common immunoglobulin A-mediated systemic vasculitis in childhood. We studied immune dysregulation in HSP by analyzing regulatory T (Treg), T helper 3 (Th3), and regu...

    Authors: Anne Filleron, Renaud Cezar, Marc Fila, Nastassja Protsenko, Kathleen Van Den Hende, Eric Jeziorski, Bob Occean, Thierry Chevallier, Pierre Corbeau and Tu Anh Tran
    Citation: Arthritis Research & Therapy 2024 26:52
  8. Rheumatoid arthritis (RA) is typically preceded by an extended preclinical period where circulating autoantibodies, particularly anti-citrullinated protein antibodies (ACPA), are detectable in the absence of c...

    Authors: Liam J. O’Neil, Vidyanand Anaparti, Tanja Winter, Irene Smolik, Xiaobo Meng, Harold M. Aukema and Hani El-Gabalawy
    Citation: Arthritis Research & Therapy 2024 26:51
  9. Capacity to work is impacted by psoriatic arthritis (PsA). Our objective was to describe the course of work productivity and leisure activity in patients with PsA treated with biologic (b) and targeted synthet...

    Authors: Laure Gossec, Brittany Humphries, Megan Rutherford, Vanessa Taieb, Damon Willems and William Tillett
    Citation: Arthritis Research & Therapy 2024 26:50
  10. We report long-term, end-of-study program safety outcomes from 25 randomized clinical trials (RCTs) in adult patients with psoriasis (PsO), psoriatic arthritis (PsA), or axial spondyloarthritis (axSpA) [includ...

    Authors: Atul Deodhar, Andrew Blauvelt, Mark Lebwohl, Meghan Feely, Andris Kronbergs, Nadezhda Eberhart, Danting Zhu, Elsa Inman, Elsie Grace, Thorsten Holzkaemper, Proton Rahman, Helena Marzo-Ortega, Kim A. Papp, Joseph F. Merola, Alice B. Gottlieb and Sergio Schwartzman
    Citation: Arthritis Research & Therapy 2024 26:49
  11. Previous studies have shown conflicting evidence regarding the incidence of cancer in patients with systemic lupus erythematosus (SLE) compared with that in healthy individuals. Calcineurin inhibitors (CNIs) s...

    Authors: Kunihiro Ichinose, Shuntaro Sato, Takashi Igawa, Momoko Okamoto, Ayuko Takatani, Yushiro Endo, Sosuke Tsuji, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Nobuyuki Yajima…
    Citation: Arthritis Research & Therapy 2024 26:48
  12. Juvenile idiopathic arthritis (JIA) is one of the most prevalent rheumatic disorders in children and is classified as an autoimmune disease (AID). While a robust genetic contribution to JIA etiology has been e...

    Authors: Daeun Kim, Jaeseung Song, Nicholas Mancuso, Serghei Mangul, Junghyun Jung and Wonhee Jang
    Citation: Arthritis Research & Therapy 2024 26:47
  13. Macrophages play an important role in the pathogenesis of lupus nephritis (LN), but less is known about macrophage subtypes in pediatric LN. Here we compared renal inflammation in LN with other inflammatory pe...

    Authors: Mira Sandersfeld, Maike Büttner-Herold, Fulvia Ferrazzi, Kerstin Amann, Kerstin Benz and Christoph Daniel
    Citation: Arthritis Research & Therapy 2024 26:46
  14. Alcohol consumption is a risk factor for hyperuricaemia and gout. Multiple single-nucleotide polymorphisms (SNPs) have been identified as associated with both alcohol consumption and serum urate or gout in sep...

    Authors: Min H Chuah, Megan P Leask, Ruth K Topless, Gregory D Gamble, Nicholas A Sumpter, Lisa K Stamp, Tony R Merriman and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2024 26:45
  15. Machine learning models can support an individualized approach in the choice of bDMARDs. We developed prediction models for 5 different bDMARDs using machine learning methods based on patient data derived from...

    Authors: Dubravka Ukalovic, Burkhard F. Leeb, Bernhard Rintelen, Gabriela Eichbauer-Sturm, Peter Spellitz, Rudolf Puchner, Manfred Herold, Miriam Stetter, Vera Ferincz, Johannes Resch-Passini, Jochen Zwerina, Marcus Zimmermann-Rittereiser and Ruth Fritsch-Stork
    Citation: Arthritis Research & Therapy 2024 26:44
  16. Sjögren’s disease is a heterogeneous autoimmune disorder that may be associated with systemic manifestations such as pulmonary or articular involvement. Systemic complications have prognostic implications and ...

    Authors: Mehrnaz Maleki-Fischbach, Liudmila Kastsianok, Matthew Koslow and Edward D. Chan
    Citation: Arthritis Research & Therapy 2024 26:43
  17. Obese RA patients have higher disease activity scores (DAS). Previous research showed that obese RA patients have higher tender joint count (TJC) and VAS general health. However, it remains unclear whether DAS...

    Authors: N. K. den Hollander, A. M. P Boeren, A. H. M. van der Helm-van Mil and H. W. van Steenbergen
    Citation: Arthritis Research & Therapy 2024 26:42
  18. Although cervical intervertebral disc (IVD) degeneration is closely associated with neck pain, its cause remains unclear. In this study, an animal model of cervical disc degeneration and discogenic neck pain i...

    Authors: Jie Li, Hui Li, Yilei Chen, Dikai Bei, Bao Huang, Kaifeng Gan, Peiming Sang, Junhui Liu, Zhi Shan, Jian Chen, Fengdong Zhao and Binhui Chen
    Citation: Arthritis Research & Therapy 2024 26:41
  19. Authors: Zhuyan Jiang, Shifei Li, Yuying Jia, Qijun Wu, Xuemeng Chen, Mengjie Zhang, Qingqing Miao, Zhiting Zhong, Zhifang Zhai, Bing Ni, Jun Xiao and Jun Tang
    Citation: Arthritis Research & Therapy 2024 26:39

    The original article was published in Arthritis Research & Therapy 2023 25:206

  20. Neuropsychiatric involvement in systemic lupus erythematosus (SLE) is a common clinical manifestation. In SLE patients, cerebral function is a more sensitive predictor of central nervous system damage, and abn...

    Authors: Lihua Ma, Yifan Yang, Shu Li, Bibhuti Upreti, Shuang Liu, Xiangyu Wang, Ru Bai, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2024 26:38
  21. The etiology of giant cell arteritis (GCA) and its predictors are incompletely understood. Previous studies have indicated reduced risk of future development of GCA in individuals with obesity and/or diabetes ...

    Authors: Karin Wadström, Lennart T. H. Jacobsson, Aladdin J. Mohammad, Kenneth J. Warrington, Eric L. Matteson and Carl Turesson
    Citation: Arthritis Research & Therapy 2024 26:37
  22. Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This ...

    Authors: Jianhua Zhang, Hao Cai, Weiwei Sun, Weijie Wu, Yunyi Nan, Yingchen Ni, Xinyuan Wu, Minhao Chen, Hua Xu and Youhua Wang
    Citation: Arthritis Research & Therapy 2024 26:36
  23. Whether rheumatoid arthritis patients have an increased risk of cervical cancer remains controversial, and further research is needed on this clinical question. This study aims to investigate the association b...

    Authors: Minxian Xu, Huan Chen, Tao Tan, Kaihong Xie, Hui Xie and Qing Li
    Citation: Arthritis Research & Therapy 2024 26:35
  24. Authors: Lichong Shen, Hanlin Yin, Li Sun, Zhiliang Zhang, Yuyang Jin, Shan Cao, Qiong Fu, Chaofan Fan, Chunde Bao, Liangjing Lu, Yifan Zhan, Xiaojiang Xu, Xiaoxiang Chen and Qingran Yan
    Citation: Arthritis Research & Therapy 2024 26:34

    The original article was published in Arthritis Research & Therapy 2023 25:151

  25. Emerging evidence suggests that extracellular vesicles (EVs) can play roles in inflammatory processes and joint degradation in primary osteoarthritis (OA), a common age-associated joint disease. EV subpopulati...

    Authors: Anne-Mari Mustonen, Mari Palviainen, Laura Säisänen, Lauri Karttunen, Sylvain Tollis, Amir Esrafilian, Jusa Reijonen, Petro Julkunen, Pia R-M Siljander, Heikki Kröger, Jussi Mäki, Jari Arokoski and Petteri Nieminen
    Citation: Arthritis Research & Therapy 2024 26:33
  26. PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, a...

    Authors: Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich and Adam Mor
    Citation: Arthritis Research & Therapy 2024 26:32
  27. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by abnormal activation of the type I interferon (IFN) pathway, which results in tissue inflammation and organ damage. We explored the ...

    Authors: Wei Fan, Bo Wei, Xuyan Chen, Yi Zhang, Pingping Xiao, Kaiyan Li, Yi qin Zhang, Jinmei Huang, Lin Leng and Richard Bucala
    Citation: Arthritis Research & Therapy 2024 26:31
  28. To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relation...

    Authors: Shirley P. Yu, Leticia A. Deveza, Virginia B. Kraus, Morten Karsdal, Anne-Christine Bay-Jensen, Jamie E. Collins, Ali Guermazi, Frank W. Roemer, Christoph Ladel, Venkatesha Bhagavath and David J. Hunter
    Citation: Arthritis Research & Therapy 2024 26:30
  29. Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are leading causes of systemic sclerosis (SSc)-related death. In this study, we aimed to identify biomarkers for detecting SSc pulmonar...

    Authors: Jing Huang, Honglin Zhu, Sijia Liu, Mengtao Li, Yisha Li, Hui Luo and Xiaoxia Zuo
    Citation: Arthritis Research & Therapy 2024 26:29
  30. To early recognise and improve the prognosis of children systemic lupus erythematosus (cSLE)-associated pancreatitis by summarising and analysing clinical features and prognosis data from 12 cases.

    Authors: Dan Zhang, Jianming Lai, Gaixiu Su, Jia Zhu, Min, Kang, Ming Li, Yingjie Xu and Li Meng
    Citation: Arthritis Research & Therapy 2024 26:28
  31. Dermatomyositis is an idiopathic inflammatory myopathy characterised by rashes and progressive muscle weakness. The recent ProDERM (Progress in DERMatomyositis) study is the first large randomised, placebo-con...

    Authors: Rohit Aggarwal, Joachim Schessl, Christina Charles-Schoeman, Zsuzsanna Bata-Csörgő, Mazen M. Dimachkie, Zoltan Griger, Sergey Moiseev, Chester V. Oddis, Elena Schiopu, Jiri Vencovský, Irene Beckmann, Elisabeth Clodi and Todd Levine
    Citation: Arthritis Research & Therapy 2024 26:27
  32. Primary Sjögren's syndrome (pSS) is an autoimmune condition that causes harm to exocrine glands and also has extra-glandular manifestations (EGM). pSS patients with EGM have a worse prognosis than those with o...

    Authors: Jingwei Hong, Hui Cheng, Ping Wang, Yanzhi Wu, Saisai Lu, Yan Zhou, Xiao bing Wang and Xiaofang Zhu
    Citation: Arthritis Research & Therapy 2024 26:26
  33. Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent pr...

    Authors: Kwanghoon Lee, Soheil Niku, Sonya J. Koo, Ernest Belezzuoli and Monica Guma
    Citation: Arthritis Research & Therapy 2024 26:25
  34. Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological fact...

    Authors: Yuchang Fei, Huan Yu, Yulun Wu and Shanshan Gong
    Citation: Arthritis Research & Therapy 2024 26:24
  35. Involvement of B cells in the pathogenesis of rheumatoid arthritis (RA) is supported by the presence of disease-specific autoantibodies and the efficacy of treatment directed against B cells. B cells that expr...

    Authors: Katrin Thorarinsdottir, Sarah McGrath, Kristina Forslind, Monica Leu Agelii, Anna-Karin Hultgård Ekwall, Lennart T. H. Jacobsson, Anna Rudin, Inga-Lill Mårtensson and Inger Gjertsson
    Citation: Arthritis Research & Therapy 2024 26:23
  36. Patients with rheumatoid arthritis (RA) showed impaired immune tolerance characterized by reduced follicular regulatory T (Tfr) cells, and they also exhibited altered gut microbiotas and their metabolites in R...

    Authors: Ruihe Wu, Dongming Wang, Liyun Cheng, Rui Su, Baochen Li, Chunxue Fan, Chong Gao and Caihong Wang
    Citation: Arthritis Research & Therapy 2024 26:21
  37. Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalanc...

    Authors: Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang and Dechun Geng
    Citation: Arthritis Research & Therapy 2024 26:20
  38. Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee...

    Authors: Joan Calvet, Antoni Berenguer-Llergo, Cristóbal Orellana, María García-Manrique, Menna Rusiñol, Silvia Garcia-Cirera, Maria Llop, Marta Arévalo, Alba Garcia-Pinilla, Carlos Galisteo, Cristina Aymerich, Rafael Gómez, Alejandra Serrano, Anna Carreras and Jordi Gratacós
    Citation: Arthritis Research & Therapy 2024 26:19
  39. Inflammatory arthritis encompasses a group of immune-mediated diseases characterized by chronic joint inflammation. Despite having pathogenic mechanisms in common, the prognosis of rheumatoid arthritis (RA), p...

    Authors: Ana Belén Azuaga, Andrea Cuervo, Raquel Celis, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Virginia Ruiz-Esquide, José A. Gómez-Puerta, Raimon Sanmartí and Julio Ramírez
    Citation: Arthritis Research & Therapy 2024 26:18
  40. Variations in bone morphology in patients with hip osteoarthritis (HOA) can be broadly categorized into three types: atrophic, normotrophic, and hypertrophic. Despite the investigations examining clinical elem...

    Authors: Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya and Kazumasa Miyatake
    Citation: Arthritis Research & Therapy 2024 26:17
  41. Advances in rheumatoid arthritis (RA) treatment, highlighted by biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), have altered the paradigm of RA treatment in...

    Authors: Takayuki Fujii, Koichi Murata, Hideo Onizawa, Akira Onishi, Masao Tanaka, Kosaku Murakami, Kohei Nishitani, Moritoshi Furu, Ryu Watanabe, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Tsuneyo Mimori, Akio Morinobu and Shuichi Matsuda
    Citation: Arthritis Research & Therapy 2024 26:16
  42. Tacrolimus is one of the major treatment options for systemic lupus erythematosus (SLE) and is considered to be a pregnancy-compatible medication. Since little is known about tacrolimus safety during pregnancy...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:15
  43. A consistent connection has been increasingly reported between rheumatoid arthritis (RA), insulin resistance (IR), and type 2 diabetes (T2D). The β-cell apoptosis induced by pro-inflammatory cytokines, which c...

    Authors: Claudia Di Muzio, Ilenia Di Cola, Azadeh Shariat Panahi, Francesco Ursini, Annamaria Iagnocco, Roberto Giacomelli, Paola Cipriani and Piero Ruscitti
    Citation: Arthritis Research & Therapy 2024 26:14
  44. To investigate the usefulness of 18F-FDG PET-CT for assessing large-vessel (LV) involvement in patients with suspected giant cell arteritis (GCA) and a negative temporal artery biopsy (TAB).

    Authors: Javier Narváez, Paula Estrada, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Joan Miquel Nolla and Montserrat Cortés-Romera
    Citation: Arthritis Research & Therapy 2024 26:13
  45. Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degene...

    Authors: Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter and Devina Purmessur
    Citation: Arthritis Research & Therapy 2024 26:12
  46. Anti-melanoma differentiation-associated gene five antibody positive (MDA5+) dermatomyositis (DM) is significantly associated with rapidly progressive interstitial lung disease (RP-ILD). Early detection of RP-ILD...

    Authors: Yulu Qiu, Xiaoke Feng, Chang Liu, Yumeng Shi, Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fang Wang and Wenfeng Tan
    Citation: Arthritis Research & Therapy 2024 26:9
  47. There is mounting proof that rheumatoid arthritis (RA) and cognitive decline are related. These studies, however, have not all been uniform, and others have not discovered such a correlation. It is essential t...

    Authors: Lincheng Duan, Shiyin Li, Haoming Li, Yue Shi, Xiaolong Xie and Yue Feng
    Citation: Arthritis Research & Therapy 2024 26:5
  48. Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a group of illnesses that cause inflammation and alterations to small vessels in the body. Some of the most common and detrimental mani...

    Authors: Megan M. Sullivan, Andy Abril, Nabeel Aslam, Colleen T. Ball and Florentina Berianu
    Citation: Arthritis Research & Therapy 2024 26:4

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