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  1. Abatacept is a recombinant fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte antigen 4 and the Fc portion of immunoglobulin (Ig) G. The mechanism of action of abatacept in rheumatoi...

    Authors: Ryosuke Fukue, Yuka Okazaki, Takahisa Gono and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2022 24:194
  2. Medication adherence is suboptimal in rheumatoid arthritis (RA) patients and impacts outcomes. DMARD-free remission (DFR) is a sustainable and achievable outcome in a minority of RA patients. Different factors...

    Authors: Irazú Contreras-Yáñez, Guillermo Arturo Guaracha-Basáñez, Maximiliano Cuevas-Montoya, José de Jesús Hernández-Bautista and Virginia Pascual-Ramos
    Citation: Arthritis Research & Therapy 2022 24:193
  3. Venous thromboembolism (VTE) is a common complication in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) and confers significant morbidity and mortality. Both acute and pa...

    Authors: C. King, R. Patel, C. Mendoza, J. K. Walker, E. Y. Wu, P. Moss, M. D. Morgan, D. O’Dell Bunch, L. Harper and D. Chanouzas
    Citation: Arthritis Research & Therapy 2022 24:192
  4. Tumor necrosis factor (TNF) inhibitors use in patients with rheumatoid arthritis (RA) has raised safety concerns about cancer risk, but study results remain controversial. This largest nationwide study to date...

    Authors: Boyoon Choi, Hyun Jin Park, Yun-Kyoung Song, Yoon-Jeong Oh, In-Wha Kim and Jung Mi Oh
    Citation: Arthritis Research & Therapy 2022 24:191
  5. We conducted a single-center cohort study of rheumatoid arthritis (RA) patients from 2011 to 2020 to understand their real world treatment and outcomes, especially changes in physical function and quality of l...

    Authors: Wataru Fukuda, Masatoshi Kadoya, Atsushi Omoto, Takuya Yanagida, Yu Isoda, Atsuhiko Sunaga, Hiroaki Kusuoka, Kentaro Ueno, Satoshi Morita, Masataka Kohno and Yutaka Kawahito
    Citation: Arthritis Research & Therapy 2022 24:190
  6. Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs...

    Authors: Abby Brumwell, Guillaume Aubourg, Juhel Hussain, Eleanor Parker, David J. Deehan, Sarah J. Rice and John Loughlin
    Citation: Arthritis Research & Therapy 2022 24:189
  7. The upregulation of interferon (IFN)-stimulated genes induced by type I IFNs (namely type I IFN signature) in rheumatoid arthritis (RA) patients had implications in early diagnosis and prediction of therapy re...

    Authors: Yu Du, Ran Cui, Na Tian, Miao Chen, Xian-Long Zhang and Sheng-Ming Dai
    Citation: Arthritis Research & Therapy 2022 24:188
  8. To assess the efficacy and safety of infliximab versus placebo in the treatment of patients with juvenile-onset spondyloarthritis (JoSpA).

    Authors: Rubén Burgos-Vargas, Adalberto Loyola-Sanchez, Sofia Ramiro, Arturo Reding-Bernal, Everardo Alvarez-Hernandez, Desirée van der Heijde and Janitzia Vázquez-Mellado
    Citation: Arthritis Research & Therapy 2022 24:187
  9. Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be...

    Authors: Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota…
    Citation: Arthritis Research & Therapy 2022 24:186
  10. To assess whether persistence to treatment with methotrexate (MTX) in early rheumatoid arthritis (RA) is shared among first-degree relatives with RA and to estimate any underlying heritability.

    Authors: Anton Öberg Sysojev, Thomas Frisell, Bénédicte Delcoigne, Saedis Saevarsdottir, Johan Askling and Helga Westerlind
    Citation: Arthritis Research & Therapy 2022 24:185
  11. Diastolic dysfunction (DD) is more prevalent in patients with rheumatoid arthritis (RA) compared to the general population. However, its evolution over time and its significant clinical predictors remain uncha...

    Authors: Elizabeth Park, Kazato Ito, Rabia Iqbal, Isabelle Amigues, Sabahat Bokhari, Jennifer Van Eyk, Christopher Depender, Jon T. Giles and Joan Bathon
    Citation: Arthritis Research & Therapy 2022 24:184
  12. There is no international consensus on an optimal ultrasound score for monitoring of rheumatoid arthritis (RA) on patient-level yet. Our aim was to reassess the US7 score for the identification of the most fre...

    Authors: A. F. Podewski, A. M. Glimm, I. Fischer, G. A. W. Bruyn, P. Hanova, H. B. Hammer, A. B. Aga, E. A. Haavardsholm, S. Ramiro, G. R. Burmester, M. Backhaus and S. Ohrndorf
    Citation: Arthritis Research & Therapy 2022 24:183
  13. Intervertebral disc (IVD) is a highly rhythmic tissue, which experiences a diurnal cycle of high/low mechanical loading via the changes of activity/rest phase. There are signs that disruption of the peripheral...

    Authors: Pandi Peng, Dong Wang, Xiaolong Xu, Di Wang, Bo Gao, Han Wang, Haoruo Jia, Qiliang Shang, Chao Zheng, Chu Gao, Jianxin Mao, Zhuojing Luo, Liu Yang and Xueyu Hu
    Citation: Arthritis Research & Therapy 2022 24:181
  14. There is limited information regarding disease-modifying antirheumatic drug (DMARD)-dependent risks of overall, incident, and recurrent herpes zoster (HZ) during first-line biologic DMARD (bDMARD) or targeted ...

    Authors: Seogsong Jeong, Seulggie Choi, Sang Min Park, Jinseok Kim, Byeongzu Ghang and Eun Young Lee
    Citation: Arthritis Research & Therapy 2022 24:180
  15. Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). Therefore, minimizing the risk of infection is an important clinical goal to improve the long-term prognosis of SLE ...

    Authors: Kazuya Abe, Yuichi Ishikawa, Yasuhiko Kita, Nobuyuki Yajima, Eisuke Inoue, Ken-ei Sada, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato and Michio Fujiwara
    Citation: Arthritis Research & Therapy 2022 24:179
  16. Studies on the association between coffee, a modifiable lifestyle factor, and rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, have been conflicting. The aim of the prese...

    Authors: Helga Westerlind, Justine Dukuzimana, Xiaomin Lu, Lars Alfredsson, Lars Klareskog and Daniela Di Giuseppe
    Citation: Arthritis Research & Therapy 2022 24:178
  17. Authors: Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli and Stefano Alivernini
    Citation: Arthritis Research & Therapy 2022 24:177

    The original article was published in Arthritis Research & Therapy 2022 24:143

  18. Spondyloarthritis (SpA) is an autoimmune and autoinflammatory musculoskeletal disease characterised by systemic enthesitis. Recent research has focused on subclinical inflammatory bowel disease (IBD) in SpA pa...

    Authors: Yuya Tabuchi, Masao Katsushima, Yuri Nishida, Mirei Shirakashi, Hideaki Tsuji, Hideo Onizawa, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Koichi Murata, Hajime Yoshifuji, Masao Tanaka, Akio Morinobu and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:176
  19. Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inh...

    Authors: Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan and Robert Terkeltaub
    Citation: Arthritis Research & Therapy 2022 24:175
  20. Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte senescence has been extensively studied in recent years. Increased numbers of senescent chondrocytes are found in OA cartil...

    Authors: Yikai Liu, Zian Zhang, Tao Li, Hao Xu and Haining Zhang
    Citation: Arthritis Research & Therapy 2022 24:174
  21. The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulm...

    Authors: Panagiota Xanthouli, Julia Miazgowski, Nicola Benjamin, Ojan Gordjani, Benjamin Egenlauf, Satenik Harutyunova, Rebekka Seeger, Alberto M. Marra, Norbert Blank, Hanns-Martin Lorenz, Ekkehard Grünig and Christina A. Eichstaedt
    Citation: Arthritis Research & Therapy 2022 24:173
  22. Insulin-like growth factor-1 (IGF-1) has the potential to be used for osteoarthritis (OA) treatment but has not been evaluated in clinics yet owing to toxicity concerns. It suffers from short intra-joint resid...

    Authors: Armin Vedadghavami, Bill Hakim, Tengfei He and Ambika G. Bajpayee
    Citation: Arthritis Research & Therapy 2022 24:172
  23. Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic and systemic inflammation. Besides, it is known that RA patients may present several comorbidities, such as sarcopenia, a condition ...

    Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espírito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:171
  24. Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles in primary Sjögren’s syndrome (pSS) remain unclear. We aimed to reveal the potenti...

    Authors: Yu Peng, Xunyao Wu, Shulan Zhang, Chuiwen Deng, Lidan Zhao, Mu Wang, Qingjun Wu, Huaxia Yang, Jiaxin Zhou, Linyi Peng, Xuan Luo, Yingying Chen, Anqi Wang, Qiufeng Xiao, Wen Zhang, Yan Zhao…
    Citation: Arthritis Research & Therapy 2022 24:170
  25. Extracellular vesicles are involved in the intercellular communication of the immune system. In rheumatoid arthritis (RA), these structures are considered a source of autoantigens that drive proinflammatory re...

    Authors: Héctor Rincón-Arévalo, Catalina Burbano, Laura Atehortúa, Mauricio Rojas, Adriana Vanegas-García, Gloria Vásquez and Diana Castaño
    Citation: Arthritis Research & Therapy 2022 24:169
  26. Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3.2) regulates neuronal excitability and plays important r...

    Authors: Brandon Itson-Zoske, Seung Min Shin, Hao Xu, Chensheng Qiu, Fan Fan, Quinn H. Hogan and Hongwei Yu
    Citation: Arthritis Research & Therapy 2022 24:168
  27. The clinical value of cryoglobulinemia (CG) in systemic lupus erythematosus (SLE) is largely unknown. The aim of this retrospective study was to describe the characteristics of CG in SLE, its impact on SLE phe...

    Authors: Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat, Sébastien Debarbieux, Denis Jullien, Pascal Sève, Laurent Juillard, Marie-Nathalie Kolopp-Sarda and Jean-Christophe Lega
    Citation: Arthritis Research & Therapy 2022 24:167
  28. To determine whether gene-gene interaction network analysis of RNA sequencing (RNA-Seq) of synovial biopsies in early rheumatoid arthritis (RA) can inform our understanding of RA pathogenesis and yield improve...

    Authors: Elisabetta Sciacca, Anna E. A. Surace, Salvatore Alaimo, Alfredo Pulvirenti, Felice Rivellese, Katriona Goldmann, Alfredo Ferro, Vito Latora, Costantino Pitzalis and Myles J. Lewis
    Citation: Arthritis Research & Therapy 2022 24:166
  29. Dietary magnesium deficiency, which is common in modern diet, has been associated with osteoarthritis (OA) susceptibility. Despite this clinical association, no study has addressed if dietary magnesium deficie...

    Authors: Ruijun Bai, Michael Z. Miao, Hui Li, Yiqing Wang, Ruixue Hou, Ke He, Xuan Wu, Hongyu Jin, Chao Zeng, Yang Cui and Guanghua Lei
    Citation: Arthritis Research & Therapy 2022 24:165
  30. Male HLA-B27-positive radiographic-axial spondyloarthritis (r-axSpA) patients are prone to have severe spinal radiographic progression, but the underlying mechanisms are unclear. We recently showed that persis...

    Authors: Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Robert D. Inman
    Citation: Arthritis Research & Therapy 2022 24:164
  31. Multiple studies have confirmed dysbiosis in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD); however, due to methodological differences across studies, it has not been possible to determine i...

    Authors: P. R. Sternes, L. Brett, J. Phipps, F. Ciccia, T. Kenna, E. de Guzman, K. Zimmermann, M. Morrison, G. Holtmann, E. Klingberg, D. Mauro, C. McIvor, H. Forsblad-d’Elia and M. A. Brown
    Citation: Arthritis Research & Therapy 2022 24:163
  32. Methotrexate is the preferred initial disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, clinically useful tools for individualized prediction of response to methotrexate trea...

    Authors: Stephanie Q. Duong, Cynthia S. Crowson, Arjun Athreya, Elizabeth J. Atkinson, John M. Davis III, Kenneth J. Warrington, Eric L. Matteson, Richard Weinshilboum, Liewei Wang and Elena Myasoedova
    Citation: Arthritis Research & Therapy 2022 24:162
  33. Osteoporosis is a global health concern with an increasing prevalence worldwide. Denosumab is an antiresoptive agent that has been demonstrated to be effective and safe in osteoporotic patients. This study aim...

    Authors: Ahmadreza Jamshidi, Mahdi Vojdanian, Mohsen Soroush, Mahmoud Akbarian, Mehrdad Aghaei, Asghar Hajiabbasi, Zahra Mirfeizi, Alireza Khabbazi, Gholamhosein Alishiri, Anousheh Haghighi, Ahmad Salimzadeh, Hadi Karimzadeh, Fatemeh Shirani, Mohammad Reza Hatef Fard, MohammadAli Nazarinia, Soosan Soroosh…
    Citation: Arthritis Research & Therapy 2022 24:161
  34. To assess markers of neutrophil activation such as calprotectin and N-formyl methionine (fMET) in anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) and large-vessel vasculitis (LVV).

    Authors: Despina Michailidou, Bhargavi Duvvuri, Runa Kuley, David Cuthbertson, Peter C. Grayson, Nader A. Khalidi, Curry L. Koening, Carol A. Langford, Carol A. McAlear, Larry W. Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine G. Sreih, Kenneth J. Warrington, Tomas Mustelin…
    Citation: Arthritis Research & Therapy 2022 24:160
  35. To investigate the safety and effectiveness of mepolizumab (MPZ), an anti-interleukin-5 antibody, as remission induction therapy for severe eosinophilic granulomatosis with polyangiitis (EGPA).

    Authors: Masanobu Ueno, Ippei Miyagawa, Takafumi Aritomi, Koichi Kimura, Shigeru Iwata, Kentaro Hanami, Syunsuke Fukuyo, Satoshi Kubo, Yusuke Miyazaki, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:159
  36. Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). There...

    Authors: Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang and Li Gao
    Citation: Arthritis Research & Therapy 2022 24:158
  37. Tumor necrosis factor (TNF) inhibitors increase the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA). This study compared the incidence of TB after treatment with TNF inhibitors and tociliz...

    Authors: Seung Min Jung, Minkyung Han, Eun Hwa Kim, Inkyung Jung and Yong-Beom Park
    Citation: Arthritis Research & Therapy 2022 24:157
  38. Muscle weakness and decreased fatigue resistance are key manifestations of systemic autoimmune myopathies (SAMs). We here examined whether high-intensity interval training (HIIT) improves fatigue resistance in...

    Authors: Takashi Yamada, Yuki Ashida, Katsuyuki Tamai, Iori Kimura, Nao Yamauchi, Azuma Naito, Nao Tokuda, Håkan Westerblad, Daniel C. Andersson and Koichi Himori
    Citation: Arthritis Research & Therapy 2022 24:156
  39. In previous clinical trials, patients with active rheumatoid arthritis (RA) treated with upadacitinib (UPA) have improved patient-reported outcomes (PROs). This post hoc analysis of SELECT-CHOICE, a phase 3 cl...

    Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:155
  40. MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inf...

    Authors: Yousra J. Dakkak, Bastiaan T. van Dijk, Friso P. Jansen, Lambertus J. Wisse, Monique Reijnierse, Annette H. M. van der Helm-van Mil and Marco C. DeRuiter
    Citation: Arthritis Research & Therapy 2022 24:154
  41. Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adv...

    Authors: Rubén Queiro, Daniel Seoane-Mato, Ana Laiz, Eva Galíndez Agirregoikoa, Carlos Montilla, Hye-Sang Park, Jose A. Pinto-Tasende, Juan J. Bethencourt Baute, Beatriz Joven Ibáñez, Elide Toniolo, Julio Ramírez and Ana Serrano García
    Citation: Arthritis Research & Therapy 2022 24:153
  42. Axial spondyloarthritis (axSpA) is a common chronic inflammatory disease, associated with extracellular matrix (ECM) remodeling of the cartilage, bone, and connective tissues. The primary symptom of axSpA is b...

    Authors: Helena Port, Signe Holm Nielsen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Morten Karsdal, Sengül Seven, Inge Juul Sørensen, Lone Morsel-Carlsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:152
  43. To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).

    Authors: Naizhuo Zhao, Audrey Smargiassi, Sonia Jean, Philippe Gamache, Elhadji-Anassour Laouan-Sidi, Hong Chen, Mark S. Goldberg and Sasha Bernatsky
    Citation: Arthritis Research & Therapy 2022 24:151
  44. Healthcare quality for systemic lupus erythematosus (SLE) is a modifiable target for improving patient outcomes. We aimed to assess the quality of care processes in different clinic settings, comparing a subsp...

    Authors: Sidha Sreedharan, Ning Li, Geoff Littlejohn, Russell Buchanan, Mandana Nikpour, Eric Morand, Alberta Hoi and Vera Golder
    Citation: Arthritis Research & Therapy 2022 24:150
  45. Long-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly characterized as prior studies measured SUA at a single time point. This s...

    Authors: Xue Tian, Yingting Zuo, Shuohua Chen, Shouling Wu, Anxin Wang and Yanxia Luo
    Citation: Arthritis Research & Therapy 2022 24:149
  46. Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosi...

    Authors: Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng and Qiang Wang
    Citation: Arthritis Research & Therapy 2022 24:148
  47. The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differenc...

    Authors: Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos van Geffen, Michiel van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John D. Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman…
    Citation: Arthritis Research & Therapy 2022 24:147
  48. Echocardiography (2DE) is integral for screening and longitudinal evaluation of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). In the present study, we sought to establish the reliability, ...

    Authors: Monica Mukherjee, Valentina Mercurio, Aparna Balasubramanian, Ami A. Shah, Steven Hsu, Catherine E. Simpson, Rachel Damico, Todd M. Kolb, Paul M. Hassoun and Stephen C. Mathai
    Citation: Arthritis Research & Therapy 2022 24:146
  49. Osteoarthritis (OA) is one of the costliest and most disabling forms of arthritis, and it poses a major public health burden; however, its detailed etiology, pathophysiology, and metabolism remain unclear. The...

    Authors: Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:145

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