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  1. Content type: Research article

    We previously identified, in newly diagnosed rheumatoid arthritis (RA) patients, networks of co-expressed genes and proteomic biomarkers associated with achieving sustained drug-free remission (sDFR) after tre...

    Authors: Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma and Floris P J G Lafeber

    Citation: Arthritis Research & Therapy 2018 20:230

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  2. Content type: Review

    Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseas...

    Authors: Jean-Luc Davignon, Benjamin Rauwel, Yannick Degboé, Arnaud Constantin, Jean-Fredéric Boyer, Andrey Kruglov and Alain Cantagrel

    Citation: Arthritis Research & Therapy 2018 20:229

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  3. Content type: Review

    Musculoskeletal ultrasound (US) is frequently used in several rheumatology practices to detect subclinical inflammation in patients with joint symptoms suspected for progression to inflammatory arthritis. Eval...

    Authors: Rosaline van den Berg, Sarah Ohrndorf, Marion C. Kortekaas and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2018 20:228

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  4. Content type: Research article

    Biologic therapy has changed the prognosis of patients with juvenile idiopathic arthritis (JIA). The aim of this study was to examine the pattern of use, drug survival, and adverse events of biologics in patie...

    Authors: Juan José Bethencourt Baute, Carlos Sanchez-Piedra, Dolores Ruiz-Montesinos, Marta Medrano San Ildefonso, Carlos Rodriguez-Lozano, Eva Perez-Pampin, Ana Ortiz, Sara Manrique, Rosa Roselló, Victoria Hernandez, Cristina Campos, Agustí Sellas, Walter Alberto Sifuentes-Giraldo, Javier García-González, Fernando Sanchez-Alonso, Federico Díaz-González…

    Citation: Arthritis Research & Therapy 2018 20:227

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  5. Content type: Research article

    Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a group of life-threatening autoimmune diseases. The epidemiological data on AAV in China are limited. The aim of the present stud...

    Authors: Jiannan Li, Zhao Cui, Jian-yan Long, Wei Huang, Jin-wei Wang, Haibo Wang, Luxia Zhang, Min Chen and Ming-hui Zhao

    Citation: Arthritis Research & Therapy 2018 20:226

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  6. Content type: Research article

    Expression of E2F transcription factor 2 (E2F2), a transcription factor related to the cell cycle, is abnormally high in rheumatoid arthritis synovial fibroblasts (RASFs). Deregulated expression of E2F2 leads ...

    Authors: Shiguan Wang, Lin Wang, Changshun Wu, Shui Sun and Ji-hong Pan

    Citation: Arthritis Research & Therapy 2018 20:225

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  7. Content type: Research article

    Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) actively drive joint inflammation and degradation by producing inflammatory cytokines and matrix-degrading molecules, making them key factors in the ...

    Authors: Le-meng Zhang, Jing-Jing Zhou and Chun-lei Luo

    Citation: Arthritis Research & Therapy 2018 20:219

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  8. Content type: Research article

    Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal flui...

    Authors: Dong-Jin Park, Seong-Ho Kim, Seong-Su Nah, Ji Hyun Lee, Seong-Kyu Kim, Yeon-Ah Lee, Seung-Jae Hong, Hyun-Sook Kim, Hye-Soon Lee, Hyoun Ah Kim, Chung-Il Joung, Sang-Hyon Kim and Shin-Seok Lee

    Citation: Arthritis Research & Therapy 2018 20:220

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  9. Content type: Research article

    Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-B...

    Authors: Paola Di Benedetto, Vasiliki Liakouli, Piero Ruscitti, Onorina Berardicurti, Francesco Carubbi, Noemi Panzera, Salvatore Di Bartolomeo, Giuliana Guggino, Francesco Ciccia, Giovanni Triolo, Paola Cipriani and Roberto Giacomelli

    Citation: Arthritis Research & Therapy 2018 20:223

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  10. Content type: Research article

    Immunoglobulin G4-related disease (IgG4-RD) promptly responds to glucocorticoids but relapses in a considerable fraction of patients. Reliable biomarkers of flare are currently lacking because the pathophysiol...

    Authors: Marco Lanzillotta, Emanuel Della-Torre, Raffaella Milani, Enrica Bozzolo, Emanuele Bozzalla-Cassione, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Stefano Partelli, Massimo Falconi, Fabio Ciceri and Lorenzo Dagna

    Citation: Arthritis Research & Therapy 2018 20:222

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  11. Content type: Research

    To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients.

    Authors: Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes and Pilar Font

    Citation: Arthritis Research & Therapy 2018 20:221

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  12. Content type: Research article

    To explore to what extent synovial hypertrophy in joints without Doppler activity is a sign of active disease, we investigated the sensitivity to change of synovial hypertrophy without Doppler activity during bio...

    Authors: Lene Terslev, Mikkel Østergaard, Joe Sexton and Hilde Berner Hammer

    Citation: Arthritis Research & Therapy 2018 20:224

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  13. Content type: Research article

    Although gender differences have been observed in the severity of axial spondyloarthritis (axSpA), gender differences in disease presentation of early axSpA have not been thoroughly investigated. In particular...

    Authors: Augusta Ortolan, Miranda van Lunteren, Sofia Ramiro, Roberta Ramonda, Robert B. M. Landewé, Hanne Dagfinrud, Lennart T. H. Jacobsson, Désirée van der Heijde and Floris A. van Gaalen

    Citation: Arthritis Research & Therapy 2018 20:218

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  14. Content type: Research article

    The aims of this study were to investigate the gene expression of CCN family members in rat intervertebral disc (IVD) cells and to examine whether Wnt–β-catenin signaling regulates the expression of CCN family...

    Authors: Akihiko Hiyama, Kosuke Morita, Daisuke Sakai and Masahiko Watanabe

    Citation: Arthritis Research & Therapy 2018 20:217

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  15. Content type: Research article

    Neuropathic-like knee pain (NKP) is often reported in individuals with knee pain (KP), but the contribution of specific central and peripheral risk factors to NKP has not been studied previously. The aims of t...

    Authors: Gwen Sascha Fernandes, Ana Marie Valdes, David Andrew Walsh, Weiya Zhang and Michael Doherty

    Citation: Arthritis Research & Therapy 2018 20:215

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  16. Content type: Research article

    The diagnosis of Behçet’s disease (BD) remains challenging due to the lack of diagnostic biomarkers. This study aims to identify potential serum metabolites associated with BD and its disease activity.

    Authors: Wenjie Zheng, Xiuhua Wu, Maryam Goudarzi, Jing Shi, Wei Song, Chaoran Li, Jinjing Liu, Hua Chen, Xuan Zhang, Xiaofeng Zeng and Heng-Hong Li

    Citation: Arthritis Research & Therapy 2018 20:214

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  17. Content type: Research article

    A recent study found that CD177 served as a receptor of membrane-bound proteinase-3 (mPR3) in a subset of neutrophils. Furthermore, CD177 has been identified as a high-affinity heterophilic binding partner for...

    Authors: Hui Deng, Nan Hu, Chen Wang, Min Chen and Ming-Hui Zhao

    Citation: Arthritis Research & Therapy 2018 20:213

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  18. Content type: Research article

    Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeut...

    Authors: Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin and Erik Lubberts

    Citation: Arthritis Research & Therapy 2018 20:212

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  19. Content type: Research article

    In this study, the effect of 15-month anti-tumor necrosis factor alpha (TNF-α) treatment on circulating levels of plasma sulfated glycosaminoglycans (GAGs) and the nonsulfated GAG hyaluronic acid (HA) in femal...

    Authors: Anna Szeremeta, Agnieszka Jura-Półtorak, Ewa Maria Koźma, Andrzej Głowacki, Eugeniusz Józef Kucharz, Magdalena Kopeć-Mędrek and Krystyna Olczyk

    Citation: Arthritis Research & Therapy 2018 20:211

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  20. Content type: Research article

    Predicting the risk of flares in patients with gout is a challenge and the link between urate burden and the risk of gout flare is unclear. The objective of this study was to determine if the extent of monosod...

    Authors: Tristan Pascart, Agathe Grandjean, Benoist Capon, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak and Jean-François Budzik

    Citation: Arthritis Research & Therapy 2018 20:210

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  21. Content type: Research article

    To be eligible to receive treatment with an anti-tumour necrosis factor (TNF), non-radiographic axial spondyloarthritis (nr-axSpA) patients require either elevated levels of C-reactive protein (CRP) (CRP > upp...

    Authors: Robert Landewé, Tommi Nurminen, Owen Davies and Dominique Baeten

    Citation: Arthritis Research & Therapy 2018 20:209

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  22. Content type: Research

    Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are...

    Authors: Ashika Chhana, Bregina Pool, Karen E. Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2018 20:208

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  23. Content type: Research article

    Studies on the relationship between osteoporosis and intervertebral disc degeneration (IVDD) are inconsistent. Therefore, we assessed whether IVDD is affected by vertebral osteoporosis in ovariectomized mice a...

    Authors: Zhi-feng Xiao, Jian-bo He, Guo-yi Su, Mei-hui Chen, Yu Hou, Shu-dong Chen and Ding-kun Lin

    Citation: Arthritis Research & Therapy 2018 20:207

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  24. Content type: Correction

    Unfortunately, after publication of this article [1], it was noticed that Fig. 2 is incorrect.

    Authors: Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson and Mats Dehlin

    Citation: Arthritis Research & Therapy 2018 20:206

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    The original article was published in Arthritis Research & Therapy 2018 20:108

  25. Content type: Research article

    Arhalofenate acid, the active acid form of arhalofenate, is a non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand, with uricosuric activity via URAT1 inhibition. Phase II studies revealed d...

    Authors: Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub and Ru Liu-Bryan

    Citation: Arthritis Research & Therapy 2018 20:204

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  26. Content type: Research article

    Comprehensive simultaneous quantification of bone erosion and enthesiophytes in the joints of patients with psoriatic arthritis (PsA) has not been performed. Herein, we aimed to compare the extent of bone eros...

    Authors: David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech and Georg Schett

    Citation: Arthritis Research & Therapy 2018 20:203

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  27. Content type: Research article

    In the present study, we investigated bone geometry, microstructure, and volumetric bone mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) in order to defin...

    Authors: Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech and Georg Schett

    Citation: Arthritis Research & Therapy 2018 20:202

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  28. Content type: Research article

    Cardiovascular disease is a leading cause of death in ANCA-associated vasculitis (AAV). An expansion of CD4+CD28null T cells is seen mainly in cytomegalovirus (CMV)-seropositive individuals and has been linked to...

    Authors: Dimitrios Chanouzas, Michael Sagmeister, Lovesh Dyall, Phoebe Sharp, Lucy Powley, Serena Johal, Jessica Bowen, Peter Nightingale, Charles J. Ferro, Matthew D. Morgan, Paul Moss and Lorraine Harper

    Citation: Arthritis Research & Therapy 2018 20:194

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  29. Content type: Research article

    Polymyositis (PM) and dermatomyositis (DM) are two distinct subgroups of idiopathic inflammatory myopathies, a chronic inflammatory disorder clinically characterized by muscle weakness and inflammatory cell in...

    Authors: Miranda Houtman, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M. Reed, Ingrid E. Lundberg and Leonid Padyukov

    Citation: Arthritis Research & Therapy 2018 20:188

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  30. Content type: Research article

    Hyperuricemia (HU) is in the causal pathway for developing clinical gout. There are few population-based assessments of the absolute and relative risk of clinically diagnosed incident gout in subjects with HU....

    Authors: Meliha C. Kapetanovic, Peter Nilsson, Carl Turesson, Martin Englund, Nicola Dalbeth and Lennart Jacobsson

    Citation: Arthritis Research & Therapy 2018 20:190

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  31. Content type: Research article

    Gout is an inflammatory arthritis caused by monosodium urate monohydrate (MSU) crystals’ joint deposition. MSU phagocytosis by resident macrophages is a key step in gout pathogenesis. MSU phagocytosis triggers...

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt and Khaled A. Elsaid

    Citation: Arthritis Research & Therapy 2018 20:192

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  32. Content type: Research article

    We aimed to investigate the efficacy of abatacept in preclinical mouse models of digestive involvement, pulmonary fibrosis, and related pulmonary hypertension (PH), mimicking internal organ involvement in syst...

    Authors: Gonçalo Boleto, Christophe Guignabert, Sonia Pezet, Anne Cauvet, Jérémy Sadoine, Ly Tu, Carole Nicco, Camille Gobeaux, Frédéric Batteux, Yannick Allanore and Jérôme Avouac

    Citation: Arthritis Research & Therapy 2018 20:197

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  33. Content type: Research article

    Fibroblast-like synovial cells (FLS) have multilineage differentiation potential including osteoblasts. We aimed to investigate the role of microRNAs during the osteogenic differentiation of rheumatoid arthrit...

    Authors: Naoki Iwamoto, Shoichi Fukui, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Takashi Igawa, Tomohiro Koga, Shin-ya Kawashiri, Kunihiro Ichinose, Mami Tmai, Hideki Nakamura, Tomoki Origuchi, Ko Chiba, Makoto Osaki, Astrid Jüngel…

    Citation: Arthritis Research & Therapy 2018 20:189

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  34. Content type: Research article

    Type III interferons (IFNs) or IFN-λs are the newly discovered cytokines that primarily target the cells of epithelial and myeloid lineages, which are major components of kidneys. The current study aimed to in...

    Authors: Ji-Yih Chen, Chin-Man Wang, Tai-Di Chen, Yeong-Jian Jan Wu, Jing-Chi Lin, Ling Ying Lu and Jianming Wu

    Citation: Arthritis Research & Therapy 2018 20:193

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  35. Content type: Research article

    Follicular helper T (Tfh) cells are specialized in helping B lymphocytes, which play a central role in autoimmune diseases that have a major B cell component, such as in rheumatoid arthritis (RA). Follicular r...

    Authors: Qian Niu, Zhuo-chun Huang, Xiao-juan Wu, Ya-xiong Jin, Yun-fei An, Ya-mei Li, Huan Xu, Bin Yang and Lan-lan Wang

    Citation: Arthritis Research & Therapy 2018 20:200

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  36. Content type: Research article

    Although exercise is an effective treatment for fibromyalgia, the relationships between lifestyle physical activity and multiple symptomology domains of fibromyalgia are not clear. Thus, the purpose of this st...

    Authors: Ericka N. Merriwether, Laura A. Frey-Law, Barbara A. Rakel, Miriam B. Zimmerman, Dana L. Dailey, Carol G. T. Vance, Meenakshi Golchha, Katherine M. Geasland, Ruth Chimenti, Leslie J. Crofford and Kathleen A. Sluka

    Citation: Arthritis Research & Therapy 2018 20:199

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  37. Content type: Research article

    In systemic sclerosis (SSc), autoantibodies provide the most accurate tool to predict the disease subset and pattern of organ involvement. Scleroderma autoantibodies target nucleic acids or DNA/RNA-binding pro...

    Authors: Elena Raschi, Cecilia Beatrice Chighizola, Laura Cesana, Daniela Privitera, Francesca Ingegnoli, Claudio Mastaglio, Pier Luigi Meroni and Maria Orietta Borghi

    Citation: Arthritis Research & Therapy 2018 20:187

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  38. Content type: Research article

    Therapeutic targeting of tumour necrosis factor (TNF)-α is highly effective in ankylosing spondylitis (AS) patients. However, since one-third of anti-TNF-treated AS patients do not show an adequate clinical re...

    Authors: Ursula Schulte-Wrede, Till Sörensen, Joachim R. Grün, Thomas Häupl, Heike Hirseland, Marta Steinbrich-Zöllner, Peihua Wu, Andreas Radbruch, Denis Poddubnyy, Joachim Sieper, Uta Syrbe and Andreas Grützkau

    Citation: Arthritis Research & Therapy 2018 20:191

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  39. Content type: Research article

    The degeneration of the intervertebral disc (IVD) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high proteogl...

    Authors: Fackson Mwale, Koichi Masuda, Michael P. Grant, Laura M. Epure, Kenji Kato, Shingo Miyazaki, Kevin Cheng, Junichi Yamada, Won C. Bae, Carol Muehleman, Peter J. Roughley and John Antoniou

    Citation: Arthritis Research & Therapy 2018 20:201

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  40. Content type: Research article

    This study aimed to determine whether, besides carotid ultrasound (US), a lateral lumbar spine radiography may also help identify ankylosing spondylitis (AS) patients at high risk of cardiovascular (CV) disease.

    Authors: Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez and Miguel A. González-Gay

    Citation: Arthritis Research & Therapy 2018 20:195

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  41. Content type: Research article

    Granulocyte–macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine that activates myeloid cells to initiate tissue inflammation. However, the molecular actions of GM-CSF against innate...

    Authors: Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2018 20:196

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  42. Content type: Research article

    Recent studies have shown a crucial role of Gαq in immune regulation, but how Gαq modulates regulatory B-cell (Breg) function is still unclear. We address this here.

    Authors: Yan He, Xiaoqing Yuan, Yan Li, Chunlian Zhong, Yuan Liu, Hongyan Qian, Jingxiu Xuan, Lihua Duan and Guixiu Shi

    Citation: Arthritis Research & Therapy 2018 20:186

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  43. Content type: Research article

    Stem cell therapy is considered as a promising alternative to treat intervertebral disc degeneration (IDD). Extensive work had been done on identifying and comparing different types of candidate stem cells, bo...

    Authors: Zhihua Han, Jiandong Wang, Liang Gao, Qiugen Wang and Jianhong Wu

    Citation: Arthritis Research & Therapy 2018 20:182

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  44. Content type: Research article

    Given the need for early detection of organ involvement in systemic sclerosis, we evaluated 99mTc-rhAnnexin V-128 for the detection of early stages of interstitial lung disease (ILD) in respective animal models u...

    Authors: Janine Schniering, Li Guo, Matthias Brunner, Roger Schibli, Shuang Ye, Oliver Distler, Martin Béhé and Britta Maurer

    Citation: Arthritis Research & Therapy 2018 20:183

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  45. Content type: Research article

    Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is one of the leading causes of death in SSc. Identification of a serum-based proteomic diagnostic biomarker for SSc-PAH would allow for ...

    Authors: Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber and Robert Layfatis

    Citation: Arthritis Research & Therapy 2018 20:185

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  46. Content type: Research article

    Lack of adequate self-care, frequent admissions, and poor quality of life are common and serious problems in adult patients with systemic lupus erythematosus (SLE). Some studies have revealed that transitional...

    Authors: Xia Xie, Yuqing Song, Hui Yang, Anliu Nie, Hong Chen and Ji-ping Li

    Citation: Arthritis Research & Therapy 2018 20:184

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  47. Content type: Research article

    Thickened skin is a major clinical feature in patients with systemic sclerosis (SSc). We investigated changes of skin thickness in patients with SSc using both high frequency ultrasound (HFU) and the modified ...

    Authors: Hongyan Li, Daniel E. Furst, Hongtao Jin, Chao Sun, Xiaoping Wang, Lin Yang, Jingjing He, Yanru Wang and Aijing Liu

    Citation: Arthritis Research & Therapy 2018 20:181

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