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  1. Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA ...

    Authors: Bei Xu, Guanhua Xu, Ye Yu and Jin Lin

    Citation: Arthritis Research & Therapy 2021 23:288

    Content type: Review

    Published on:

  2. Osteoarthritis (OA) subsequent to acute joint injury accounts for a significant proportion of all arthropathies. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor ce...

    Authors: Lixia Zhang, Cameron L. Kirkwood, Jiho Sohn, Ashley Lau, Mary Bayers-Thering, Supinder Kour Bali, Sridhar Rachala, John M. Marzo, Mark J. Anders, Frank Beier and Keith L. Kirkwood

    Citation: Arthritis Research & Therapy 2021 23:287

    Content type: Research article

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  3. Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-I...

    Authors: Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen and Gabriel Mbalaviele

    Citation: Arthritis Research & Therapy 2021 23:286

    Content type: Research article

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  4. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren

    Citation: Arthritis Research & Therapy 2021 23:285

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:269

  5. This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering alg...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh and Jaejoon Lee

    Citation: Arthritis Research & Therapy 2021 23:284

    Content type: Research article

    Published on:

  6. We have recently demonstrated that serum CCL20 levels positively correlate with mean pulmonary arterial pressure in patients with systemic sclerosis (SSc). Considering a proangiogenic effect of CCL20 on endoth...

    Authors: Tetsuya Ikawa, Takuya Miyagawa, Yuki Fukui, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Yuta Norimatsu, Yusuke Watanabe, Ayumi Yoshizaki, Shinichi Sato and Yoshihide Asano

    Citation: Arthritis Research & Therapy 2021 23:283

    Content type: Research article

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  7. Authors: Francesca Ometto, Augusta Ortolan, Davide Farber, Mariagrazia Lorenzin, Giulia Dellamaria, Giacomo Cozzi, Marta Favero, Romina Valentini, Andrea Doria and Roberta Ramonda

    Citation: Arthritis Research & Therapy 2021 23:282

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:219

  8. To assess the first-year features of patients with chronic nonbacterial osteomyelitis (CNO).

    Authors: Christiane Reiser, Jens Klotsche, Anton Hospach, Rainer Berendes, Anja Schnabel, Annette F. Jansson, Markus Hufnagel, Nadine Grösch, Martina Niewerth, Kirsten Minden and Hermann Girschick

    Citation: Arthritis Research & Therapy 2021 23:281

    Content type: Research article

    Published on:

  9. Anterior cruciate ligament (ACL) and meniscus tears are common knee injuries. Despite the high rate of post-traumatic osteoarthritis (PTOA) following these injuries, the contributing factors remain unclear. In...

    Authors: Sophia Y. Kim-Wang, Abigail G. Holt, Alyssa M. McGowan, Stephanie T. Danyluk, Adam P. Goode, Brian C. Lau, Alison P. Toth, Jocelyn R. Wittstein, Louis E. DeFrate, John S. Yi and Amy L. McNulty

    Citation: Arthritis Research & Therapy 2021 23:280

    Content type: Research article

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  10. Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...

    Authors: Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning and Xu-jie Zhou

    Citation: Arthritis Research & Therapy 2021 23:279

    Content type: Research article

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  11. Clinical trials show intensive treatment to induce remission is effective in patients with highly active rheumatoid arthritis (RA). The TITRATE trial showed that the benefits of intensive treatment also extend...

    Authors: Sook Yan Lee, Fowzia Ibrahim, Brian D. M. Tom, Elena Nikiphorou, Frances M. K. Williams, Heidi Lempp and David L. Scott

    Citation: Arthritis Research & Therapy 2021 23:278

    Content type: Research article

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  12. Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a...

    Authors: Caining Wen, Limei Xu, Xiao Xu, Daping Wang, Yujie Liang and Li Duan

    Citation: Arthritis Research & Therapy 2021 23:277

    Content type: Review

    Published on:

  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid

    Citation: Arthritis Research & Therapy 2021 23:276

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:241

  14. To clarify the frequency and outcome of patients with systemic lupus erythematosus (SLE) who achieved the clinical state as serologically active clinically quiescent (SACQ) and to identify factors associated w...

    Authors: Hong Huang, Lin Mu, Zhuoli Zhang, Dai Gao, Yanjie Hao and Wei Zhou

    Citation: Arthritis Research & Therapy 2021 23:275

    Content type: Research article

    Published on:

  15. Identification of predictive clinical factors of long-term treatment response may contribute to improved management of non-radiographic axSpA (nr-axSpA) patients. This analysis aims to identify whether any bas...

    Authors: Walter P. Maksymowych, Thomas Kumke, Simone E. Auteri, Bengt Hoepken, Lars Bauer and Martin Rudwaleit

    Citation: Arthritis Research & Therapy 2021 23:274

    Content type: Research article

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  16. Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA). However, it remains unclear how the periph...

    Authors: Takayuki Matsushita, Kazuhiro Otani, Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka and Fusao Kato

    Citation: Arthritis Research & Therapy 2021 23:273

    Content type: Research article

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  17. Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor ...

    Authors: H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes and F. A. van Gaalen

    Citation: Arthritis Research & Therapy 2021 23:272

    Content type: Research article

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  18. Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, reports of its use and subsequent fatal arrhythmias in patients with coronavirus...

    Authors: Elizabeth Park, Jon T. Giles, Thania Perez-Recio, Paloma Pina, Christopher Depender, Yevgeniya Gartshteyn, Anca D. Askanase, Joan Bathon and Laura Geraldino-Pardilla

    Citation: Arthritis Research & Therapy 2021 23:271

    Content type: Research article

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  19. Self-efficacy, or patients’ confidence in their ability to control disease and its consequences, was recently prioritised in EULAR recommendations for inflammatory arthritis self-management strategies. However...

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren

    Citation: Arthritis Research & Therapy 2021 23:269

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:285

  20. A considerable proportion of patients with rheumatoid arthritis (RA) also suffer from hand osteoarthritis (OA). We here assess the association between conventional synthetic (cs) and biological (b) disease-mod...

    Authors: C. A. Lechtenboehmer, T. Burkard, S. Reichenbach, U. A. Walker, A. M. Burden and T. Hügle

    Citation: Arthritis Research & Therapy 2021 23:267

    Content type: Research article

    Published on:

  21. Connective tissue growth factor (CTGF)-induced angiogenesis is a crucial factor in rheumatoid arthritis (RA), but CTGF-interacting protein and related molecular mechanism of their interaction have not been ful...

    Authors: Guoyu Yin, Chenglin Yang, Gan Wu, Xinxin Yu, Qingqing Tian, Daoxing Chen, Ben Cao, Lin Zhao, Nannan Xu, Shengwei Jin, Wei Zhang and Jianguang Wang

    Citation: Arthritis Research & Therapy 2021 23:266

    Content type: Research article

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  22. The development and optimization of therapies for rheumatoid arthritis (RA) is currently hindered by a lack of methods for early non-invasive monitoring of treatment response. Annexin A2, an inflammation-assoc...

    Authors: Shaw-Wei D. Tsen, Luke E. Springer, Krishna Sharmah Gautam, Rui Tang, Kexian Liang, Gail Sudlow, Amir Kucharski, Christine T. N. Pham and Samuel Achilefu

    Citation: Arthritis Research & Therapy 2021 23:265

    Content type: Research article

    Published on:

  23. Infectious disease is an increasing threat to patients with systemic lupus erythematosus (SLE); however, the long-term outcome in critically ill septic patients with SLE remains unclear, and we aimed to addres...

    Authors: Hsin-Hua Chen, Hsian-Min Chen, Yi-Ming Chen, Yi-Hsing Chen, Ching-Heng Lin and Wen-Cheng Chao

    Citation: Arthritis Research & Therapy 2021 23:264

    Content type: Research article

    Published on:

  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: R. E. Costello, J. H. Humphreys, J. C. Sergeant, M. Haris, F. Stirling, K. Raza, D. van Schaardenburg and Ian N. Bruce

    Citation: Arthritis Research & Therapy 2021 23:263

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:210

  25. The identification of patients with knee osteoarthritis (OA) likely to progress rapidly in terms of structure is critical to facilitate the development of disease-modifying drugs.

    Authors: Jean-Baptiste Schiratti, Rémy Dubois, Paul Herent, David Cahané, Jocelyn Dachary, Thomas Clozel, Gilles Wainrib, Florence Keime-Guibert, Agnes Lalande, Maria Pueyo, Romain Guillier, Christine Gabarroca and Philippe Moingeon

    Citation: Arthritis Research & Therapy 2021 23:262

    Content type: Research article

    Published on:

  26. Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis, with a higher incidence of malignancy. The aim of this study is to identify biomarkers for predicting mali...

    Authors: Yuzhou Gan, Yi Sun, Jiayang Jin, Yifan Wang, Jiali Chen, Yukchiu Chung, Xue Li and Hua Ye

    Citation: Arthritis Research & Therapy 2021 23:261

    Content type: Research article

    Published on:

  27. To identify potential biomarkers to distinguish familial Mediterranean fever (FMF) from sepsis.

    Authors: Tomohiro Koga, Kaori Furukawa, Kiyoshi Migita, Shimpei Morimoto, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Yushiro Endo, Remi Sumiyoshi, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Tomoki Origuchi, Takahiro Maeda, Akihiro Yachie…

    Citation: Arthritis Research & Therapy 2021 23:260

    Content type: Research article

    Published on:

  28. Serum proteins can be readily assessed during routine clinical care. However, it is unclear to what extent serum proteins reflect the molecular dysregulations of peripheral blood cells (PBCs) or affected end-o...

    Authors: Victor Farutin, Elma Kurtagic, Joël R. Pradines, Ishan Capila, Maureen D. Mayes, Minghua Wu, Anthony M. Manning and Shervin Assassi

    Citation: Arthritis Research & Therapy 2021 23:259

    Content type: Research article

    Published on:

  29. Patients with rheumatoid arthritis (RA) are almost twice as likely to develop cardiovascular disease (CVD) as those without. However, traditional CVD risks have been shown to underperform in RA patients; thus,...

    Authors: Seungwoo Han, Na-Ri Kim, Jong-Wan Kang, Jung-Su Eun and Young-Mo Kang

    Citation: Arthritis Research & Therapy 2021 23:258

    Content type: Research article

    Published on:

  30. Primary Sjögren’s syndrome (pSS) is a chronic systemic autoimmune disease which has focal lymphocytic infiltration including a majority of CD4+ T cells. This study was to investigate the correlation of periphe...

    Authors: Qi Wang, Nan Che, Chengyin Lu, Xiaoxuan Sun, Yanyan Wang, Qiang Wang, Wenfeng Tan, Lanlan Zhou, Xiaojun Zhang, Dong Xu, Lei Gu and Miaojia Zhang

    Citation: Arthritis Research & Therapy 2021 23:257

    Content type: Research article

    Published on:

  31. Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder. Diagnosing AOSD can be challenging, as disease presentation and clinical course are highly heterogeneous. For unclear reasons, a few...

    Authors: Anaïs Wahbi, Benoît Tessoulin, Cédric Bretonnière, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Sophie Georgin-Lavialle, Mohamed Hamidou…

    Citation: Arthritis Research & Therapy 2021 23:256

    Content type: Research article

    Published on:

  32. Authors: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina…

    Citation: Arthritis Research & Therapy 2021 23:255

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:239

  33. Few studies on rheumatoid arthritis (RA) have generated machine learning models to predict biologic disease-modifying antirheumatic drugs (bDMARDs) responses; however, these studies included insufficient analy...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Jaejoon Lee, Eun-Mi Koh and Hoon-Suk Cha

    Citation: Arthritis Research & Therapy 2021 23:254

    Content type: Research article

    Published on:

  34. The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA.

    Authors: Dennis M. Minton, Christian J. Elliehausen, Martin A. Javors, Kelly S. Santangello and Adam R. Konopka

    Citation: Arthritis Research & Therapy 2021 23:253

    Content type: Research article

    Published on:

  35. The occurrence of health events preceding a psoriatic arthritis (PsA) diagnosis may serve as predictors of diagnosis. We sought to assess patients’ real-world experiences in obtaining a PsA diagnosis.

    Authors: Alexis Ogdie, Martin Rozycki, Theresa Arndt, Cheng Shi, Nina Kim and Peter Hur

    Citation: Arthritis Research & Therapy 2021 23:252

    Content type: Research article

    Published on:

  36. Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies re...

    Authors: Yanlin Cao, Yenan Zhan, Sujun Qiu, Zhong Chen, Kaiqin Gong, Songjia Ni and Yang Duan

    Citation: Arthritis Research & Therapy 2021 23:251

    Content type: Research article

    Published on:

  37. Patients with autoimmune diseases often present with olfactory impairment. The aim of the study was to assess the olfactory functions of patients with primary Sjögren’s syndrome and to correlate these findings...

    Authors: Xue Xu, Linyu Geng, Chen Chen, Wentao Kong, Baojie Wen, Wei Kong, Siwen Chen, Huayong Zhang, Jun Liang and Lingyun Sun

    Citation: Arthritis Research & Therapy 2021 23:250

    Content type: Research article

    Published on:

  38. Retroperitoneal fibrosis (RPF) is characterized by a highly fibrotic retroperitoneal mass and encompasses the idiopathic form and secondary to malignancies. Because we have limited knowledge whether RPF is ass...

    Authors: Sang Jin Lee, Jung Su Eun, Min Jung Kim, Yeong Wook Song and Young Mo Kang

    Citation: Arthritis Research & Therapy 2021 23:249

    Content type: Research article

    Published on:

  39. REFLECTIONS B538–02 is a randomized, double-blind comparative study of the adalimumab (ADL) biosimilar PF-06410293, (ADL-PF), and reference ADL sourced from the European Union (ADL-EU) in patients with active ...

    Authors: Roy M. Fleischmann, Daniel F. Alvarez, Amy E. Bock, Carol Cronenberger, Ivana Vranic, Wuyan Zhang and Rieke Alten

    Citation: Arthritis Research & Therapy 2021 23:248

    Content type: Research article

    Published on:

  40. In patients with axial spondyloarthritis (axSpA), monocytes show a pre-activated phenotype. Gut inflammation is a trigger of monocyte activation and may also affect their development in the bone marrow (BM). A...

    Authors: Fabian Karow, Biljana Smiljanovic, Joachim R. Grün, Denis Poddubnyy, Fabian Proft, Alice Talpin, Christophe Hue, Anne Boland, Jean-François Deleuze, Henri-Jean Garchon, Ilkay Ergenç, Ann-Sophie De Craemer, Ulrike Erben, Thomas Häupl, Dirk Elewaut, Maxime Breban…

    Citation: Arthritis Research & Therapy 2021 23:246

    Content type: Research article

    Published on:

  41. Certain risk alleles associated with autoantibody-positive rheumatoid arthritis (RA) have been linked to poorer prognoses. In patients with autoantibody-positive RA, abatacept shows differential efficacy to tu...

    Authors: William Rigby, Jane H. Buckner, S. Louis Bridges Jr, Marleen Nys, Sheng Gao, Martin Polinsky, Neelanjana Ray and Vivian Bykerk

    Citation: Arthritis Research & Therapy 2021 23:245

    Content type: Research article

    Published on:

  42. Isopsoralen (IPRN), one of the active ingredients of Psoralea corylifolia Linn, has anti-inflammatory properties. We attempted to investigate the inhibitory effects of IPRN on rheumatoid arthritis (RA) and charac...

    Authors: Yi Han, Jinguang Wang, Shufeng Li, Yi Li, Yongli Zhang, Ruojia Zhang, Yuang Zhang, Huancai Fan, Haojun Shi, Jihong Pan, Guanhua Song, Luna Ge and Lin Wang

    Citation: Arthritis Research & Therapy 2021 23:243

    Content type: Research article

    Published on:

  43. TPX-100, a promotor of osteoblast and chondroblast differentiation, is a potential osteoarthritis (OA) therapy. This retrospective study compared MRI 3D femoral bone shape changes (B-scores) after intra-articular...

    Authors: Dawn McGuire, Michael Bowes, Alan Brett, Neil A. Segal, Meghan Miller, David Rosen and Yoshinari Kumagai

    Citation: Arthritis Research & Therapy 2021 23:242

    Content type: Research article

    Published on:

  44. Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophag...

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid

    Citation: Arthritis Research & Therapy 2021 23:241

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:276

  45. Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence...

    Authors: Mingzhu Wang, Zhengyang Zhu, Xiaoying Lin, Haichang Li, Chengping Wen, Jie Bao and Zhixing He

    Citation: Arthritis Research & Therapy 2021 23:240

    Content type: Research article

    Published on:

  46. There is a need for biomarker to identify patients “at risk” for rheumatoid arthritis (risk-RA) and to better predict the therapeutic response and in this study we tested the hypothesis that novel native and c...

    Authors: Bianka Marklein, Madeleine Jenning, Zoltán Konthur, Thomas Häupl, Franziska Welzel, Ute Nonhoff, Sylvia Krobitsch, Debbie M. Mulder, Marije I. Koenders, Vijay Joshua, Andrew P. Cope, Mark J. Shlomchik, Hans-Joachim Anders, Gerd R. Burmester, Aase Hensvold, Anca I. Catrina…

    Citation: Arthritis Research & Therapy 2021 23:239

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:255

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