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  1. Research article

    Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

    Ankylosing spondylitis (AS) is a chronic rheumatic and autoimmune disease. Little is known about the potential role of DNA methylation in the pathogenesis of AS. This study was undertaken to explore the potent...

    Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo and Feng Zhang

    Arthritis Research & Therapy 2017 19:177

    Published on: 25 July 2017

  2. Research article

    Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

    The study was performed to evaluate whether targeted alpha-2-macroglobulin (A2M) variants have a similar or enhanced function at wild-type (wt)-A2M to attenuate cartilage degeneration in vivo.

    Yang Zhang, Xiaochun Wei, Shawn Browning, Gaetano Scuderi, Lewis S. Hanna and Lei Wei

    Arthritis Research & Therapy 2017 19:175

    Published on: 25 July 2017

  3. Research article

    Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

    A novel anti-mouse CD3ε antibody, Dow2, recognizes mouse CD3ε without activating T cells and suppresses T-cell activation. The purpose of this study was to determine whether Dow2 can inhibit T cells in uveitis.

    Sunao Sugita, Jun Shimizu, Kenichi Makabe, Hiroshi Keino, Takeshi Watanabe and Masayo Takahashi

    Arthritis Research & Therapy 2017 19:176

    Published on: 25 July 2017

  4. Research article

    CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

    Primary Sjögren’s syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. In the current study, we aimed to in...

    Cristiano Alessandri, Francesco Ciccia, Roberta Priori, Elisa Astorri, Giuliana Guggino, Riccardo Alessandro, Aroldo Rizzo, Fabrizio Conti, Antonina Minniti, Cristiana Barbati, Marta Vomero, Monica Pendolino, Annacarla Finucci, Elena Ortona, Tania Colasanti, Marina Pierdominici…

    Arthritis Research & Therapy 2017 19:178

    Published on: 25 July 2017

  5. Research article

    RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

    Dermatomyositis (DM) is inflammatory myopathy or myositis characterized by muscle weakness and skin manifestations. In the differential diagnosis of DM the evaluation of the muscle biopsy is of importance amon...

    Xavier Suárez-Calvet, Eduard Gallardo, Iago Pinal-Fernandez, Noemi De Luna, Cinta Lleixà, Jordi Díaz-Manera, Ricardo Rojas-García, Ivan Castellví, M. Angeles Martínez, Josep M. Grau, Albert Selva-O’Callaghan and Isabel Illa

    Arthritis Research & Therapy 2017 19:174

    Published on: 24 July 2017

  6. Review

    Emerging technologies in autoantibody testing for rheumatic diseases

    Testing for the presence of antinuclear antibodies (ANAs) is a key step in the diagnosis of systemic lupus erythematosus (SLE) and other systemic autoimmune rheumatic diseases (SARD). The standard slide-based ...

    Nancy J. Olsen, May Y. Choi and Marvin J. Fritzler

    Arthritis Research & Therapy 2017 19:172

    Published on: 24 July 2017

  7. Research article

    Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study

    Nephrolithiasis (NL) is known to be associated with gout, although there are few comparative studies on risk and risk factors for NL in gout compared to population cohorts. In this cohort study we investigated...

    A. J. Landgren, L. T. H. Jacobsson, U. Lindström, T. Z. S. Sandström, P. Drivelegka, L. Björkman, E. Fjellstedt and M. Dehlin

    Arthritis Research & Therapy 2017 19:173

    Published on: 24 July 2017

  8. Research article

    Ultrasonography and dual-energy computed tomography provide different quantification of urate burden in gout: results from a cross-sectional study

    Ultrasonography (US) and dual-energy computed tomography (DECT) can assess urate burden in gout. The objective of this study was to compare the quantification of urate deposition provided by US to the one prov...

    Tristan Pascart, Agathe Grandjean, Laurène Norberciak, Vincent Ducoulombier, Marguerite Motte, Hélène Luraschi, Marie Vandecandelaere, Catherine Godart, Eric Houvenagel, Nasser Namane and Jean-François Budzik

    Arthritis Research & Therapy 2017 19:171

    Published on: 21 July 2017

  9. Review

    Settings and artefacts relevant for Doppler ultrasound in large vessel vasculitis

    Ultrasound is used increasingly for diagnosing large vessel vasculitis (LVV). The application of Doppler in LVV is very different from in arthritic conditions. This paper aims to explain the most important Dop...

    L. Terslev, A. P. Diamantopoulos, U. Møller Døhn, W. A. Schmidt and S. Torp-Pedersen

    Arthritis Research & Therapy 2017 19:167

    Published on: 20 July 2017

  10. Research article

    Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

    There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in a 2-year randomized controlled trial in patients with kn...

    Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme and Jean-Pierre Pelletier

    Arthritis Research & Therapy 2017 19:169

    Published on: 20 July 2017

  11. Research article

    Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy

    Methotrexate is endorsed to be used as first-line treatment in rheumatoid arthritis (RA). However, a large proportion of patients need additional treatment with a biological disease-modifying anti-rheumatic dr...

    Xavier M. Teitsma, Johannes W. G. Jacobs, Michal Mokry, Michelle E. A. Borm, Attila Pethö-Schramm, Jacob M. van Laar, Johannes W. J. Bijlsma and Floris P. J. Lafeber

    Arthritis Research & Therapy 2017 19:170

    Published on: 20 July 2017

  12. Research article

    A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRA®) to the reference product (Humira®) in patients with active rheumatoid arthritis

    This study aimed to compare efficacy and safety of test-adalimumab (CinnoRA®, CinnaGen, Iran) to the innovator product (Humira®, AbbVie, USA) in adult patients with active rheumatoid arthritis (RA).

    Ahmadreza Jamshidi, Farhad Gharibdoost, Mahdi Vojdanian, Soosan G. Soroosh, Mohsen Soroush, Arman Ahmadzadeh, Mohammad Ali Nazarinia, Mohammad Mousavi, Hadi Karimzadeh, Mohammad Reza Shakibi, Zahra Rezaieyazdi, Maryam Sahebari, Asghar Hajiabbasi, Ali Asghar Ebrahimi, Najmeh Mahjourian and Amin Mohammadinejad Rashti

    Arthritis Research & Therapy 2017 19:168

    Published on: 20 July 2017

  13. Research article

    Sustained benefit from combined plasmapheresis and allogeneic mesenchymal stem cells transplantation therapy in systemic sclerosis

    Systemic sclerosis (SSc) is an autoimmune disease involving the skin and several internal organs. Most therapies available for this disease are symptomatic. Given the difficulty in treating SSc, we conducted t...

    Huayong Zhang, Jun Liang, Xiaojun Tang, Dandan Wang, Xuebing Feng, Fan Wang, Bingzhu Hua, Hong Wang and Lingyun Sun

    Arthritis Research & Therapy 2017 19:165

    Published on: 19 July 2017

  14. Research article

    Impact of obesity on the response to tumor necrosis factor inhibitors in axial spondyloarthritis

    Few studies have investigated the impact of obesity on the response to tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). The aim of our study was to investigate the impa...

    Raphael Micheroli, Monika Hebeisen, Lukas M. Wildi, Pascale Exer, Giorgio Tamborrini, Jürg Bernhard, Burkhard Möller, Pascal Zufferey, Michael J. Nissen, Almut Scherer and Adrian Ciurea

    Arthritis Research & Therapy 2017 19:164

    Published on: 19 July 2017

  15. Research article

    Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

    Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of the joints, leading to bone erosion and joint dysfunction. Despite the recent successes of disease-modifying an...

    Susan MacLauchlan, Maria A. Zuriaga, José J. Fuster, Carla M. Cuda, Jennifer Jonason, Fernanda Behzadi, Jennifer Parker Duffen, G. Kenneth Haines III, Tamar Aprahamian, Harris Perlman and Kenneth Walsh

    Arthritis Research & Therapy 2017 19:166

    Published on: 19 July 2017

  16. Research article

    Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis

    Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by uncontrolled joint inflammation and destruction of bone and cartilage. We previously reported that C-X-C motif chemokine 10 (CXCL10; a...

    Jong-Ho Lee, Bongjun Kim, Won Jong Jin, Hong-Hee Kim, Hyunil Ha and Zang Hee Lee

    Arthritis Research & Therapy 2017 19:163

    Published on: 19 July 2017

  17. Commentary

    The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?

    Systemic sclerosis is considered a disease dominated by a “loss of angiogenesis”, although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primar...

    Marco Matucci-Cerinic, Mirko Manetti, Cosimo Bruni, Ines Chora, Silvia Bellando-Randone, Gemma Lepri, Amato De Paulis and Serena Guiducci

    Arthritis Research & Therapy 2017 19:162

    Published on: 6 July 2017

  18. Research article

    Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

    A hallmark of osteoarthritis is increased proteolytic cleavage of aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive cartilage degradation by activating proteases in both t...

    Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky and André Struglics

    Arthritis Research & Therapy 2017 19:157

    Published on: 5 July 2017

  19. Research article

    Factors associated with initial or subsequent choice of biologic disease-modifying antirheumatic drugs for treatment of rheumatoid arthritis

    Biologic disease-modifying antirheumatic drugs (DMARDs) are increasingly used for rheumatoid arthritis (RA) treatment. However, little is known based on contemporary data about the factors associated with DMAR...

    Yinzhu Jin, Rishi J. Desai, Jun Liu, Nam-Kyong Choi and Seoyoung C. Kim

    Arthritis Research & Therapy 2017 19:159

    Published on: 5 July 2017

  20. Research article

    Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis

    The aim was to study changes in immunohistochemical expression markers of synovial and skin inflammation, clinical outcomes and magnetic resonance imaging (MRI) scores with abatacept treatment in patients with...

    Agnes Szentpetery, Eric Heffernan, Martina Gogarty, Lisa Mellerick, Janet McCormack, Muhammad Haroon, Musaab Elmamoun, Phil Gallagher, Genevieve Kelly, Aurelie Fabre, Brian Kirby and Oliver FitzGerald

    Arthritis Research & Therapy 2017 19:158

    Published on: 5 July 2017

  21. Research article

    IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

    The Fc glycosylation of immunoglobulin G (IgG) is well known to associate with rheumatoid arthritis (RA) disease activity. The same may be true for other classes of Igs. In the present study, we sought to dete...

    Albert Bondt, Simone Nicolardi, Bas C. Jansen, T. Martijn Kuijper, Johanna M. W. Hazes, Yuri E. M. van der Burgt, Manfred Wuhrer and Radboud J. E. M. Dolhain

    Arthritis Research & Therapy 2017 19:160

    Published on: 5 July 2017

  22. Research article

    Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition

    Stringent remission criteria are crucial in rheumatoid arthritis (RA) assessment. Disease activity score in 28 joints (DAS28)-remission has not been included among American College of Rheumatology/European Lea...

    M. Schoels, F. Alasti, J. S. Smolen and D. Aletaha

    Arthritis Research & Therapy 2017 19:155

    Published on: 4 July 2017

  23. Research article

    Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

    Systemic sclerosis (SSc; scleroderma) is an uncommon autoimmune rheumatic disease characterised by autoimmunity, vasculopathy and fibrosis. Gene expression profiling distinguishes scleroderma from normal skin,...

    Emma C. Derrett-Smith, Viktor Martyanov, Cecilia B. Chighizola, Pia Moinzadeh, Corrado Campochiaro, Korsa Khan, Tammara A. Wood, Pier Luigi Meroni, David J. Abraham, Voon H. Ong, Robert Lafyatis, Michael L. Whitfield and Christopher P. Denton

    Arthritis Research & Therapy 2017 19:156

    Published on: 4 July 2017

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