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  1. Psoriatic Arthritis (PsA) is an immune-mediated disease with heterogenous symptoms indicating differences in the underlying immunopathogenesis. The primary objective of the study explored the dynamic mechanism...

    Authors: Marie Skougaard, Sisse B. Ditlev, Zara R. Stisen, Laura C. Coates, Karen Ellegaard and Lars Erik Kristensen
    Citation: Arthritis Research & Therapy 2022 24:262
  2. Numerous potential therapeutic alternatives for intervertebral disc degeneration (IDD) have been investigated, the most promising of which are based on biological variables such as microRNAs (miRNAs). Therefor...

    Authors: Zhonghui Chen, Jianghua Ming, Yajing Liu, Geliang Hu and Qi Liao
    Citation: Arthritis Research & Therapy 2022 24:261
  3. Intra-articular injection is indicated for mild or moderate osteoarthritis (OA). However, the superiority of cell-based injection and the role of diverse cell sources are still unclear. This study aimed to com...

    Authors: Yijian Zhang, Huilin Yang, Fan He and Xuesong Zhu
    Citation: Arthritis Research & Therapy 2022 24:260
  4. Non-neuropsychiatric systemic lupus erythematosus (non-NPSLE) has been confirmed to have subtle changes in brain structure before the appearance of obvious neuropsychiatric symptoms. Previous literature mainly...

    Authors: Shu Li, Ru Bai, Yifan Yang, Ruotong Zhao, Bibhuti Upreti, Xiangyu Wang, Shuang Liu, Yuqi Cheng and Jian Xu
    Citation: Arthritis Research & Therapy 2022 24:259
  5. Current recommendations on the management of systemic sclerosis (SSc) suggest that autologous hematopoietic stem cell therapy (HSCT) can be a rescue therapy for patients with rapidly progressive SSc.

    Authors: Norbert Blank, Marc Schmalzing, Pia Moinzadeh, Max Oberste, Elise Siegert, Ulf Müller-Ladner, Gabriela Riemekasten, Claudia Günther, Ina Kötter, Gabriele Zeidler, Christiane Pfeiffer, Aaron Juche, Ilona Jandova, Jan Ehrchen, Laura Susok, Tim Schmeiser…
    Citation: Arthritis Research & Therapy 2022 24:258
  6. To investigate the occurrence and frequency of anti-citrullinated protein antibodies (ACPA) to cyclic citrullinated type II collagen (COL2) epitope with a capacity to bind joint cartilage.

    Authors: Qixing Li, Yanpeng Li, Bibo Liang, Rui Xu, Bingze Xu, Erik Lönnblom, Hui Feng, Jing’an Bai, Roma Stawikowska, Changrong Ge, Aiping Lu, Gregg B. Fields, Lianbo Xiao and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2022 24:257
  7. Dysbiotic intestinal and oral microbiota have been implicated in the pathogenesis of rheumatoid arthritis (RA), but the mechanisms how microbiota could impact disease activity have remained elusive. The aim of...

    Authors: J. Parantainen, G. Barreto, R. Koivuniemi, H. Kautiainen, D. Nordström, E. Moilanen, M. Hämäläinen, M. Leirisalo-Repo, K. Nurmi and K. K. Eklund
    Citation: Arthritis Research & Therapy 2022 24:256
  8. The prevalence of rheumatoid arthritis (RA) in persons 60 years or older is estimated to be 2%. Late-onset rheumatoid arthritis (LORA) is traditionally defined as the onset of RA after the age of 60 years. Com...

    Authors: Xiuying Li, Angela Cesta, Mohammad Movahedi and Claire Bombardier
    Citation: Arthritis Research & Therapy 2022 24:255
  9. EC-18, a synthetic monoacetyldiaglyceride, exhibits protective effects against lung inflammation, allergic asthma, and abdominal sepsis. However, there have been no investigations to determine whether EC-18 ha...

    Authors: Jin-Sil Park, Seung Cheon Yang, Ha Yeon Jeong, Seon-Young Lee, Jun-Geol Ryu, Jeong Won Choi, Hye Yeon Kang, Sung-Min Kim, Sun-Hee Hwang, Mi-La Cho and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2022 24:254
  10. This study aimed to investigate the trajectory of damage accrual, associated factors, and impact on health-related quality of life (HR-QoL) in a multicenter cohort of patients with Behçet’s syndrome (BS) over ...

    Authors: Alberto Floris, Matteo Piga, Riccardo Laconi, Gerard Espinosa, Giuseppe Lopalco, Luisa Serpa Pinto, Nikolaos Kougkas, Jurgen Sota, Andrea Lo Monaco, Marcello Govoni, Luca Cantarini, George Bertsias, João Correia, Florenzo Iannone, Ricard Cervera, Carlos Vasconcelos…
    Citation: Arthritis Research & Therapy 2022 24:253
  11. Pain-sensitized osteoarthritis and fibromyalgia patients characteristically show nociceptive system augmented responsiveness as a common feature. However, sensitization can be originally related to the periphe...

    Authors: Jesus Pujol, Laura Blanco-Hinojo, Andrea Doreste, Fabiola Ojeda, Gerard Martínez-Vilavella, Víctor Pérez-Sola, Joan Deus and Jordi Monfort
    Citation: Arthritis Research & Therapy 2022 24:252
  12. To evaluate the levels of periostin in patients with systemic sclerosis (SSc) and their association with features of systemic sclerosis.

    Authors: Fatima El-Adili, Justin K. Lui, Mortada Najem, Giuseppina Farina, Maria Trojanowska, Flora Sam and Andreea M. Bujor
    Citation: Arthritis Research & Therapy 2022 24:251
  13. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​s13075-022-02950-3.

    Authors: Yanhong Li, Jing Wang, Yanchao Ma, Wenjia Du, Haijun Feng, Kai Feng, Guangjie Li and Shuanke Wang
    Citation: Arthritis Research & Therapy 2022 24:250
  14. Macrophages are key innate immune cells implicated in the pathogenesis of Behçet’s disease (BD), and macrophage polarization plays a pivotal role in inflammatory response. This study aimed to investigate the r...

    Authors: Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen and Wenjie Zheng
    Citation: Arthritis Research & Therapy 2022 24:249
  15. Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:248

    The original article was published in Arthritis Research & Therapy 2022 24:155

  16. The cytoskeletal protein, PSTPIP2, is associated with inflammation and is predominantly expressed in macrophages. Previous data have shown that PSTPIP2 inhibits articular bone damage in arthritic rats. The aim...

    Authors: Yao Yao, Xiaoyu Cai, Meng Zhang, Xiao Zhang, Fujia Ren, Yan Zheng, Weidong Fei, Mengdan Zhao and Caihong Zheng
    Citation: Arthritis Research & Therapy 2022 24:247
  17. Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espirito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:246

    The original article was published in Arthritis Research & Therapy 2022 24:245

  18. We read with great interest the article by Hein et al., which described the meta-analysis study on the impact of disease-modifying anti-rheumatic drugs (DMARDs) therapy on skeletal muscle mass in rheumatoid ar...

    Authors: Hiroto Minamino, Mie Torii, Masao Katsushima, Yoshihito Fujita and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:245

    The original article was published in Arthritis Research & Therapy 2022 24:171

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:246

  19. Authors: Koichiro Komiya, Hiroyuki Enomoto, Isao Inoki, Satoko Okazaki, Yoshinari Fujita, Eiji Ikeda, Eiko Ohuchi, Hideo Matsumoto, Yoshiaki Toyama and Yasunori Okada
    Citation: Arthritis Research & Therapy 2022 24:244

    The original article was published in Arthritis Research & Therapy 2005 7:R1158

  20. Observational studies have demonstrated associations between gout and hypertension, but whether they are causal remains unclear. Our work aims to assess the causal relationship between gout and hypertension.

    Authors: Benjamin Lai, Huang-Ping Yu, Yu-Jing Chang, Liang-Chin Wang, Che-Kai Chen, Weiya Zhang, Michael Doherty, Shang-Hung Chang, Jun-Te Hsu, Kuang-Hui Yu and Chang-Fu Kuo
    Citation: Arthritis Research & Therapy 2022 24:243
  21. Clustering is an important clinical feature of Behçet’s syndrome (BS) and may have pathogenetic and therapeutic implications. Recent and previous studies on BS phenotype differ substantially in terms of method...

    Authors: Ufuk İlgen
    Citation: Arthritis Research & Therapy 2022 24:242
  22. In patients with tracheobronchial involvement, the differential diagnosis between granulomatosis with polyangiitis (GPA) and relapsing polychondritis (RP) can be challenging. The aim of this study was to descr...

    Authors: Carole Jalaber, Xavier Puéchal, Ines Saab, Emma Canniff, Benjamin Terrier, Luc Mouthon, Eglantine Cabanne, Sandra Mghaieth, Marie-Pierre Revel and Guillaume Chassagnon
    Citation: Arthritis Research & Therapy 2022 24:241
  23. We compared the treatment effectiveness between guselkumab and adalimumab in patients with pustulotic arthro-osteitis (PAO). In addition, we performed peripheral blood immunophenotyping to elucidate the immuno...

    Authors: Masanobu Ueno, Ippei Miyagawa, Yusuke Miyazaki, Kentaro Hanami, Shunsuke Fukuyo, Satoshi Kubo, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:240
  24. Authors: Jingjing Zhu, Zheng Niu, Lars Alfredsson, Lars Klareskog, Leonid Padyukov and Xia Jiang
    Citation: Arthritis Research & Therapy 2022 24:239

    The original article was published in Arthritis Research & Therapy 2022 24:237

  25. With great interest, we have read the recent article “Age at menarche, age at natural menopause, and risk of rheumatoid arthritis — a Mendelian randomization study” by Zhu et al. While we have a great apprecia...

    Authors: Zhenqian Wang and Jiawen Lu
    Citation: Arthritis Research & Therapy 2022 24:237

    The original article was published in Arthritis Research & Therapy 2021 23:108

    The Letter to this article has been published in Arthritis Research & Therapy 2022 24:239

  26. Endothelial dysfunction contributes to increased cardiovascular (CV) disease in rheumatoid arthritis (RA). Angiogenic T cells (Tang) are a key regulator of vascular function via their interaction with endothel...

    Authors: Giacomo Cafaro, Eleonora Petito, Onelia Bistoni, Emanuela Falcinelli, Sabrina Cipriani, Maria Chiara Borghi, Angelo F. Bonifacio, Elisa Giglio, Alessia Alunno, Carlo Perricone, Roberto Gerli, Paolo Gresele and Elena Bartoloni
    Citation: Arthritis Research & Therapy 2022 24:236
  27. Animal models of spontaneous osteoarthritis (OA) are sparse and not well characterized. The purpose of the present study is to examine OA-related changes and mechanisms in senescence-accelerated mouse prone 8 ...

    Authors: Yohei Sanada, Yasunari Ikuta, Chenyang Ding, Masahiro Shinohara, Dilimulati Yimiti, Hiroyuki Ishitobi, Keita Nagira, Minjung Lee, Takayuki Akimoto, Sachi Shibata, Masakazu Ishikawa, Tomoyuki Nakasa, Kiminori Matsubara, Martin K. Lotz, Nobuo Adachi and Shigeru Miyaki
    Citation: Arthritis Research & Therapy 2022 24:235
  28. Abnormal proliferation of fibroblast-like synoviocytes (FLSs) in the synovial lining layer is the primary cause of synovial hyperplasia and joint destruction in rheumatoid arthritis (RA). Currently, the relati...

    Authors: Ying Lu, Chongbo Hao, Shanshan Yu, Zuan Ma, Xuelian Fu, Mingqing Qin, Menglei Ding, Zengguang Xu and Lieying Fan
    Citation: Arthritis Research & Therapy 2022 24:234
  29. The purpose of this study was to stratify patients with rheumatoid arthritis (RA) according to the trend of disease activity by trajectory-based clustering and to identify contributing factors for treatment re...

    Authors: Bon San Koo, Seongho Eun, Kichul Shin, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Ji Seon Oh
    Citation: Arthritis Research & Therapy 2022 24:233
  30. To evaluate the impact of cardiovascular risk (CVR) on the diagnostic accuracy of the ultrasonographic (US) Halo Score in patients with suspected giant cell arteritis (GCA).

    Authors: Juan Molina-Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Julia Martínez-Barrio, Ana M. Anzola Alfaro, Javier Rivera and José María Álvaro-Gracia
    Citation: Arthritis Research & Therapy 2022 24:232
  31. Osteoarthritis (OA) is a common chronic condition but its association with other chronic conditions and mortality is largely unknown. This study aimed to use latent class analysis (LCA) of 30 comorbidities in ...

    Authors: Dawit T. Zemedikun, Helena Lee, Krishnarajah Nirantharakumar, Karim Raza, Joht Singh Chandan, Janet M. Lord and Thomas A. Jackson
    Citation: Arthritis Research & Therapy 2022 24:231
  32. Rheumatoid arthritis (RA) is characterized by the presence of disease-specific autoreactive B cell responses, in particular those generating anti-citrullinated protein antibodies (ACPA). For many years, Epstei...

    Authors: Sanne Kroos, Arieke S. B. Kampstra, René E. M. Toes, Linda M. Slot and Hans U. Scherer
    Citation: Arthritis Research & Therapy 2022 24:230
  33. Gout is a highly hereditary disease, but not all those carrying well-known risk variants have developing gout attack even in hyperuricemia status. We performed a genome-wide association study (GWAS) and polyge...

    Authors: Ya-Sian Chang, Chien-Yu Lin, Ting-Yuan Liu, Chung-Ming Huang, Chin-Chun Chung, Yu-Chia Chen, Fuu-Jen Tsai, Jan-Gowth Chang and Shun-Jen Chang
    Citation: Arthritis Research & Therapy 2022 24:229
  34. Adipose-derived mesenchymal stem cells (ASCs) have gained attention as a new treatment for systemic sclerosis (SSc). Low-molecular-weight heparin (LMWH) enhances cell function and stimulates the production of ...

    Authors: Takayasu Suzuka, Takuya Kotani, Takashi Saito, Shogo Matsuda, Takako Sato and Tohru Takeuchi
    Citation: Arthritis Research & Therapy 2022 24:228
  35. X-ray images are commonly used to assess the bone destruction of rheumatoid arthritis. The purpose of this study is to propose an automatic-bone-destruction-evaluation system fully utilizing deep neural networ...

    Authors: Kazuki Miyama, Ryoma Bise, Satoshi Ikemura, Kazuhiro Kai, Masaya Kanahori, Shinkichi Arisumi, Taisuke Uchida, Yasuharu Nakashima and Seiichi Uchida
    Citation: Arthritis Research & Therapy 2022 24:227
  36. To detect dorsally located osteophytes (OP) on lateral x-ray views and to correlate their presence with the extent of structural joint damage, determined by histologic grading (cartilage damage and synovial in...

    Authors: Ilse-Gerlinde Sunk, Love Amoyo-Minar, Birgit Niederreiter, Afschin Soleiman, Franz Kainberger, Josef S. Smolen, Daniel Aletaha and Klaus Bobacz
    Citation: Arthritis Research & Therapy 2022 24:226
  37. Fibroblast-like synoviocytes (FLS) play a crucial role in JIA pathogenesis; however, the mechanisms by which they contribute to disease progression are not well described. Previous studies demonstrated that rh...

    Authors: Megan M. Simonds, Kathleen E. Sullivan and AnneMarie C. Brescia
    Citation: Arthritis Research & Therapy 2022 24:225
  38. Authors: Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi and Shinsuke Yasuda
    Citation: Arthritis Research & Therapy 2022 24:224

    The original article was published in Arthritis Research & Therapy 2022 24:45

  39. Subchondral bone plays an important role in the pathogenesis of radiographic osteoarthritis (OA). However, the bony changes that occur in hand OA (HOA) are much less understood. This study aimed to describe th...

    Authors: Canchen Ma, Dawn Aitken, Feitong Wu, Kathryn Squibb, Flavia Cicuttini and Graeme Jones
    Citation: Arthritis Research & Therapy 2022 24:223
  40. Rheumatoid arthritis (RA) patients present with abnormal methylation patterns in their fibroblast-like synoviocytes (FLS). Given that DNA demethylation is critical for producing DNA methylation patterns, we hy...

    Authors: Akio Kawabe, Kaoru Yamagata, Shigeaki Kato, Kazuhisa Nakano, Kei Sakata, Yu-ichi Tsukada, Koichiro Ohmura, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:222
  41. Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS), a type of autologous anti-inflammatory orthobiolo...

    Authors: Alexis N. Peña, Sven D. Sommerfeld, Amy E. Anderson, Jin Han, David R. Maestas Jr, Joscelyn C. Mejias, Jennifer Woodell-May, William King, Sudipto Ganguly and Jennifer H. Elisseeff
    Citation: Arthritis Research & Therapy 2022 24:221
  42. The IL-23/IL-17 axis is involved in inflammatory diseases including arthritis and psoriasis. However, the response to IL-23 or IL-17 inhibitors is different depending on the disease. The aim was to compare the...

    Authors: Mélissa Noack and Pierre Miossec
    Citation: Arthritis Research & Therapy 2022 24:220
  43. Cardiac involvement in patients with idiopathic inflammatory myopathies (IIM) is associated with increased morbidity and mortality risk; however, little is known about the progression of cardiac dysfunction an...

    Authors: Andrea Péter, Ágnes Balogh, Zoltán Csanádi, Katalin Dankó and Zoltan Griger
    Citation: Arthritis Research & Therapy 2022 24:219
  44. Pain is the main concern of patients with rheumatoid arthritis (RA) while reducing disease activity dominates specialist management. Disease activity assessments like the disease activity score for 28 joints w...

    Authors: Fowzia Ibrahim, Margaret Ma, David L. Scott and Ian C. Scott
    Citation: Arthritis Research & Therapy 2022 24:218
  45. To investigate whether the associations between cartilage defects and cartilage volumes with changes in knee symptoms were mediated by osteophytes.

    Authors: Tianxiang Fan, Shibo Chen, Muhui Zeng, Jia Li, Xiaoshuai Wang, Guangfeng Ruan, Peihua Cao, Yan Zhang, Tianyu Chen, Qianhua Ou, Qianyi Wang, Anita E. Wluka, Flavia Cicuttini, Changhai Ding and Zhaohua Zhu
    Citation: Arthritis Research & Therapy 2022 24:217
  46. Osteoarthritis (OA) is a chronic degenerative joint disease. Extracellular matrix (ECM) degradation is essential for OA progression. Previous studies have shown that circular RNAs (circRNAs) are involved in th...

    Authors: Wenzhong Que, Huili Liu and Qinqin Yang
    Citation: Arthritis Research & Therapy 2022 24:216
  47. Fibroblasts are important structural cells in synovium and play key roles in maintaining the synovial homeostasis. By single-cell RNA sequencing (scRNA-seq), subpopulation of synovium-resident cells has been r...

    Authors: Nachun Chen, Baoying Fan, Zhiyong He, Xinping Yu and Jinjun Wang
    Citation: Arthritis Research & Therapy 2022 24:215
  48. To identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore whether there are other ways to affect the progression of IDD.

    Authors: Zhenyu Wang, Yuguang Zhao, Yi Liu, Zhigang Qu, Xinming Zhuang, Qingxu Song, Haoyu Li and Jiali Leng
    Citation: Arthritis Research & Therapy 2022 24:214
  49. Patients with immune thrombocytopenia (ITP) have a risk of developing systemic lupus erythematosus (SLE). We sought to examine the clinical characteristics of patients with primary ITP who later developed SLE ...

    Authors: Soo Min Ahn, Eun-Ji Choi, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong
    Citation: Arthritis Research & Therapy 2022 24:213

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