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  1. Content type: Research article

    Chronic, low-grade inflammation of the synovium (synovitis) is a hallmark of osteoarthritis (OA), thus understanding of OA immunobiology, mediated by immune effectors, is of importance. Specifically, monocytes...

    Authors: Alejandro Gómez-Aristizábal, Rajiv Gandhi, Nizar N. Mahomed, K. Wayne Marshall and Sowmya Viswanathan

    Citation: Arthritis Research & Therapy 2019 21:26

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  2. Content type: Research article

    A high prevalence of periodontitis has been reported in rheumatoid arthritis (RA) patients, although the strength of this association, its temporal link and the possible relationship between the severity of pe...

    Authors: Beatriz Rodríguez-Lozano, Jerián González-Febles, Jorge Luis Garnier-Rodríguez, Shashi Dadlani, Sagrario Bustabad-Reyes, Mariano Sanz, Fernando Sánchez-Alonso, Carlos Sánchez-Piedra, Enrique González-Dávila and Federico Díaz-González

    Citation: Arthritis Research & Therapy 2019 21:27

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  3. Content type: Research article

    Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies like rheumatoid factor (RF), anti-cyclic citrullinated peptide-2 (anti-CCP2), and anti-carbamylated protein (anti-CarP) antibodies. ...

    Authors: Emma C. de Moel, Veerle F. A. M. Derksen, Leendert A. Trouw, Holger Bang, Gerard Collée, Leroy R. Lard, Sofia Ramiro, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes and Diane van der Woude

    Citation: Arthritis Research & Therapy 2019 21:28

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  4. Content type: Research article

    This study aimed to assess the minimal clinically important differences (MCIDs) for the modified Rodnan skin score (mRSS) using combined data from the Scleroderma Lung Studies (I and II).

    Authors: Dinesh Khanna, Philip J. Clements, Elizabeth R. Volkmann, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Michael D. Roth, Oliver Distler and Donald P. Tashkin

    Citation: Arthritis Research & Therapy 2019 21:23

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  5. Content type: Research article

    To assess the value of contrast-enhanced ultrasonography (CEUS) for monitoring disease activity of Takayasu arteritis (TA).

    Authors: Ling-Ying Ma, Chao-Lun Li, Li-Li Ma, Xiao-Meng Cui, Xiao-Min Dai, Ying Sun, Hui-Yong Chen, Bei-Jian Huang and Lin-Di Jiang

    Citation: Arthritis Research & Therapy 2019 21:24

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  6. Content type: Research article

    In a cohort of patients with newly diagnosed psoriatic arthritis (PsA) who received usual care, we investigated the impact of time elapsed to minimal disease activity (MDA) on health-related quality of life (H...

    Authors: Kim Wervers, Jolanda J. Luime, Ilja Tchetverikov, Andreas H. Gerards, Marc R. Kok, Cathelijne W. Y. Appels, Wiebo L. van der Graaff, Johannes H. L. M. van Groenendael, Lindy-Anne Korswagen, Josien J. Veris-van Dieren, Johanna M. W. Hazes and Marijn Vis

    Citation: Arthritis Research & Therapy 2019 21:25

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  7. Content type: Research article

    To investigate the association between 12 single nucleotide polymorphisms (SNPs) located on ERAP1 and IL23R with the presence of inflammation on the sacroiliac joint (SIJ) or spinal magnetic resonance imagery (MR...

    Authors: Adeline Ruyssen-Witrand, Cécile Luxembourger, Alain Cantagrel, Delphine Nigon, Pascal Claudepierre, Yannick Degboe and Arnaud Constantin

    Citation: Arthritis Research & Therapy 2019 21:22

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  8. Content type: Research article

    The aim of the study was to evaluate a simplified version of the Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS) for five joints of the hand (RAMRIS-5) in patients with early rheumatoid arthriti...

    Authors: Miriam Frenken, Christoph Schleich, Ralph Brinks, Daniel Benjamin Abrar, Christine Goertz, Matthias Schneider, Benedikt Ostendorf and Philipp Sewerin

    Citation: Arthritis Research & Therapy 2019 21:21

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  9. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the affiliation of Ari Polachek.

    Authors: Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman and Lihi Eder

    Citation: Arthritis Research & Therapy 2019 21:20

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    The original article was published in Arthritis Research & Therapy 2017 19:189

  10. Content type: Research article

    Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-...

    Authors: Sabine Trellu, Alice Courties, Stéphane Jaisson, Laëtitia Gorisse, Philippe Gillery, Saadia Kerdine-Römer, Carlos Vaamonde-Garcia, Xavier Houard, François-Paul Ekhirch, Alain Sautet, Bertrand Friguet, Claire Jacques, Francis Berenbaum and Jérémie Sellam

    Citation: Arthritis Research & Therapy 2019 21:18

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  11. Content type: Research article

    The aim of this study was to investigate whether vitamin D plays a protective role in podocyte injury induced by autoantibodies purified from the serum of patients with lupus nephritis (LN) via reducing aberra...

    Authors: Qi Yu, Yingjin Qiao, Dongwei Liu, Fengxun Liu, Congcong Gao, Jiayu Duan, Lulu Liang, Xueqi Di, Yi Yuan, Yukui Gao, Siwan Cui, Yilu Qin, Tianfang Li, Zhaohui Zheng and Zhangsuo Liu

    Citation: Arthritis Research & Therapy 2019 21:19

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  12. Content type: Research article

    Obesity is over-represented in patients with psoriatic arthritis (PsA) and associated with higher disease activity, poorer effect of treatment and increased cardiovascular morbidity. Studies on the effects of ...

    Authors: Eva Klingberg, Annelie Bilberg, Sofia Björkman, Martin Hedberg, Lennart Jacobsson, Helena Forsblad-d’Elia, Hans Carlsten, Björn Eliasson and Ingrid Larsson

    Citation: Arthritis Research & Therapy 2019 21:17

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  13. Content type: Research article

    Ultrasonography (US) can directly demonstrate joint inflammation, including grayscale (GS) signs of synovial hypertrophy and power Doppler (PD) techniques to demonstrate increased blood flow and vascularizatio...

    Authors: Yasushi Kondo, Katsuya Suzuki, Yumiko Inoue, Koumei Sakata, Chihiro Takahashi, Masaru Takeshita, Yoshiaki Kassai, Takahiro Miyazaki, Rimpei Morita, Yasuo Niki, Yuko Kaneko, Hidekata Yasuoka, Kunihiro Yamaoka, Akihiko Yoshimura and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2019 21:14

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  14. Content type: Review

    Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyl...

    Authors: Zoltán Szekanecz, Hennie G. Raterman, Zsófia Pethő and Willem F. Lems

    Citation: Arthritis Research & Therapy 2019 21:15

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  15. Content type: Research article

    Development of autoimmune diseases is the result of a complex interplay between hereditary and environmental factors, with multiple genes contributing to the pathogenesis in human disease and in experimental m...

    Authors: Samra Sardar, Alish Kerr, Daniëlle Vaartjes, Emilie Riis Moltved, Edita Karosiene, Ramneek Gupta and Åsa Andersson

    Citation: Arthritis Research & Therapy 2019 21:16

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  16. Content type: Research article

    Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ ...

    Authors: Ravi K. Narang, Ruth Topless, Murray Cadzow, Greg Gamble, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:13

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  17. Content type: Research

    The objective was to determine if dose reduction is non-inferior to full-dose TNFi to maintain low disease activity (LDA) in patients already in remission with TNFi, in axial spondyloarthritis.

    Authors: Jordi Gratacós, Caridad Pontes, Xavier Juanola, Jesús Sanz, Ferran Torres, Cristina Avendaño, Antoni Vallano, Gonzalo Calvo, Eugenio de Miguel and Raimon Sanmartí

    Citation: Arthritis Research & Therapy 2019 21:11

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  18. Content type: Research article

    Adult-onset Still’s disease (AOSD) is a systemic inflammatory disease characterized by neutrophilia and NLRP3 inflammasome and macrophage activation. We investigated the role of neutrophil extracellular traps ...

    Authors: Qiongyi Hu, Hui Shi, Ting Zeng, Honglei Liu, Yutong Su, Xiaobing Cheng, Junna Ye, Yufeng Yin, Mengru Liu, Hui Zheng, Xinyao Wu, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Yue Sun, Jialin Teng…

    Citation: Arthritis Research & Therapy 2019 21:9

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  19. Content type: Research article

    Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) is an innate-immune receptor found in blood. Its presence reflects innate immune cell activation. We sought to investigate plasma sTREM-1 leve...

    Authors: Yonatan Edel, Vitaly Kliminski, Elisheva Pokroy-Shapira, Shirly Oren, Ariela Dortort Lazar, Yael Pri-Paz Basson, Mohammad Egbaria and Yair Molad

    Citation: Arthritis Research & Therapy 2019 21:10

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  20. Content type: Research article

    Fibroblast-like synoviocytes (FLS) and CCR7 effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, wh...

    Authors: Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko and Christine Beeton

    Citation: Arthritis Research & Therapy 2019 21:6

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  21. Content type: Research article

    In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical...

    Authors: Nicola Dalbeth, Graeme Jones, Robert Terkeltaub, Dinesh Khanna, Maple Fung, Scott Baumgartner and Fernando Perez-Ruiz

    Citation: Arthritis Research & Therapy 2019 21:8

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  22. Content type: Research article

    A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healin...

    Authors: Nicoletta Del Papa, Gabriele Di Luca, Romina Andracco, Eleonora Zaccara, Wanda Maglione, Francesca Pignataro, Antonina Minniti and Claudio Vitali

    Citation: Arthritis Research & Therapy 2019 21:7

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  23. Content type: Research article

    The circadian clock plays a crucial role in regulating physiology and is important for maintaining immune homeostasis and responses to inflammatory stimuli. Inflammatory arthritis often shows diurnal variation...

    Authors: Laura E. Hand, Suzanna H. Dickson, Anthony J. Freemont, David W. Ray and Julie E. Gibbs

    Citation: Arthritis Research & Therapy 2019 21:5

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  24. Content type: Research article

    Infliximab, an anti-tumor necrosis factor-alpha antibody, has been reported to have excellent efficacy for refractory uveoretinitis in Behçet’s disease (RUBD), and was approved for this indication in Japan. Ho...

    Authors: Shigeaki Ohno, Itsuro Umebayashi, Miyuki Matsukawa, Takashi Goto and Toshiro Yano

    Citation: Arthritis Research & Therapy 2019 21:2

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  25. Content type: Research article

    Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise bacterial metabolites presented by MHC class I-related protein 1 (MR1). Bacterial dysbiosis has been implicated in auto-inflam...

    Authors: Hester Koppejan, Diahann T. S. L. Jansen, Marjolijn Hameetman, Ranjeny Thomas, Rene E. M. Toes and Floris A. van Gaalen

    Citation: Arthritis Research & Therapy 2019 21:3

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  26. Content type: Research

    We aimed to evaluate the prevalence of hip and knee osteoarthritis (HOA and KOA) according to American College of Rheumatology (ACR) criteria among participants with suspected early symptomatic osteoarthritis ...

    Authors: Jurgen Damen, Rogier M. van Rijn, Pieter J. Emans, Willem K. H. A. Hilberdink, Janet Wesseling, Edwin H. G. Oei and Sita M. A. Bierma-Zeinstra

    Citation: Arthritis Research & Therapy 2019 21:4

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  27. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Figs. 2C and 5C.

    Authors: Daniel J. Leong, Marwa Choudhury, Regina Hanstein, David M. Hirsh, Sun Jin Kim, Robert J. Majeska, Mitchell B. Schaffler, John A. Hardin, David C. Spray, Mary B. Goldring, Neil J. Cobelli and Hui B. Sun

    Citation: Arthritis Research & Therapy 2019 21:1

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    The original article was published in Arthritis Research & Therapy 2014 16:508

  28. Content type: Research article

    Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol approved in the United States for treatment of chronic refractory gout. It can profoundly decrease serum urate to < 1 mg/dl. In ...

    Authors: Brian F. Mandell, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2018 20:286

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  29. Content type: Research

    Ankylosing spondylitis (AS) begins early in life and often leads to reduced physical function, but less is known about the impacts it has on health-related quality of life (HRQoL). The aims of this study were ...

    Authors: Lucy Law, Jeanette Beckman Rehnman, Anna Deminger, Eva Klingberg, Lennart T. H. Jacobsson and Helena Forsblad-d’Elia

    Citation: Arthritis Research & Therapy 2018 20:284

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  30. Content type: Research article

    The availability of methotrexate and the introduction of multiple biological agents have revolutionized the treatment of juvenile idiopathic arthritis (JIA). Several international and national drug registries ...

    Authors: Joost Swart, Gabriella Giancane, Gerd Horneff, Bo Magnusson, Michael Hofer, Еkaterina Alexeeva, Violeta Panaviene, Brigitte Bader-Meunier, Jordi Anton, Susan Nielsen, Fabrizio De Benedetti, Sylvia Kamphuis, Valda Staņēviča, Maria Tracahana, Laura Marinela Ailioaie, Elena Tsitsami…

    Citation: Arthritis Research & Therapy 2018 20:285

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  31. Content type: Research article

    Sarcopenic obesity, associated with greater risk of cardiovascular disease (CVD) and mortality in rheumatoid arthritis (RA), may be related to dysregulated muscle remodeling. To determine whether exercise trai...

    Authors: Brian J. Andonian, David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus and Kim M. Huffman

    Citation: Arthritis Research & Therapy 2018 20:283

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  32. Content type: Research article

    To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc).

    Authors: Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón-Aznar, Eduardo L. Callejas-Moraga, Carles Tolosa-Vilella, Serafín Alonso-Vila, Vicente Fonollosa-Pla and Albert Selva-O’Callaghan

    Citation: Arthritis Research & Therapy 2018 20:281

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  33. Content type: Research article

    The value of joint ultrasonography (US) in the prediction of clinical arthritis in individuals at risk of developing rheumatoid arthritis (RA) is still a point of debate, due to varying scanning protocols and ...

    Authors: Marian H. van Beers-Tas, Annelies B. Blanken, Mark M. J. Nielen, Franktien Turkstra, Conny J. van der Laken, Marlies Meursinge Reynders and Dirkjan van Schaardenburg

    Citation: Arthritis Research & Therapy 2018 20:279

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  34. Content type: Research article

    The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort.

    Authors: Javier Narváez, Helena Borrell, Fernando Sánchez-Alonso, Iñigo Rúa-Figueroa, Francisco Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Alejandro Olivé, José Luis Andreu, Víctor Martínez-Taboada, Joan Miquel Nolla and José María Pego-Reigosa

    Citation: Arthritis Research & Therapy 2018 20:280

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  35. Content type: Correction

    Following publication of the original article [1], the authors reported an error in the spelling of the ninth author’s name.

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:282

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    The original article was published in Arthritis Research & Therapy 2018 20:265

  36. Content type: Research article

    CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active ...

    Authors: Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier and Andrea Steinborn

    Citation: Arthritis Research & Therapy 2018 20:278

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  37. Content type: Research article

    The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD).

    Authors: Shin-ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi and Atsushi Kawakami

    Citation: Arthritis Research & Therapy 2018 20:277

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  38. Content type: Research article

    Calprotectin is a biomarker of disease activity in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and predicts relapse in juvenile idiopathic arthritis. Higher drug trough serum levels are associated ...

    Authors: José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete and Raimon Sanmarti

    Citation: Arthritis Research & Therapy 2018 20:275

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  39. Content type: Research article

    The objective was to evaluate the 25(OH) vitamin D (25(OH)D) status of patients with juvenile idiopathic arthritis (JIA) and determine whether the 25(OH)D level is associated with disease activity and the cour...

    Authors: Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink and Kirsten Minden

    Citation: Arthritis Research & Therapy 2018 20:276

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  40. Content type: Research article

    Rheumatoid arthritis (RA) is associated with a high prevalence of atherosclerosis. Recently increased levels of microparticles (MPs) have been reported in patients with RA. MPs could represent a link between a...

    Authors: Cristiana Barbati, Marta Vomero, Tania Colasanti, Marco Diociaiuti, Fulvia Ceccarelli, Sara Ferrigno, Annacarla Finucci, Francesca Miranda, Lucia Novelli, Carlo Perricone, Francesca Romana Spinelli, Simona Truglia, Fabrizio Conti, Guido Valesini and Cristiano Alessandri

    Citation: Arthritis Research & Therapy 2018 20:273

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  41. Content type: Research

    Secukinumab has demonstrated sustained improvement in the signs and symptoms of psoriatic arthritis (PsA) over 2 years in the FUTURE 2 study (NCT01752634). This post hoc analysis assessed the ability of secuki...

    Authors: L. C. Coates, D. D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, T. K. Kvien, L. Gossec, V. Strand, L. Rasouliyan, L. Pricop, K. Ding, S. M. Jugl and C. Gaillez

    Citation: Arthritis Research & Therapy 2018 20:272

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  42. Content type: Research article

    Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis repo...

    Authors: Lebin Song, Yi Wang, Jiayi Zhang, Ninghong Song, Xiaoyun Xu and Yan Lu

    Citation: Arthritis Research & Therapy 2018 20:270

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  43. Content type: Research article

    Increasing evidence indicates a pathogenic role of deregulated autophagy in rheumatoid arthritis (RA). We examined the relationship between autophagy and inflammatory parameters in patients with RA receiving b...

    Authors: Yi-Ming Chen, Chun-Yu Chang, Hsin-Hua Chen, Chia-Wei Hsieh, Kuo-Tung Tang, Meng-Chun Yang, Joung-Liang Lan and Der-Yuan Chen

    Citation: Arthritis Research & Therapy 2018 20:268

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  44. Content type: Research

    Comorbidities are common in chronic systemic connective tissue diseases and are associated with adverse outcomes, increased morbidity and mortality. Although the prevalence of comorbidities has been well-studi...

    Authors: Stylianos Panopoulos, Maria Tektonidou, Alexandros A. Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V. Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos and Petros P. Sfikakis

    Citation: Arthritis Research & Therapy 2018 20:267

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  45. Content type: Research article

    Common carotid artery intima-media thickness (CIMT), as measured by ultrasound, has utility in stratification of the accelerated cardiovascular risk seen in rheumatoid arthritis (RA); however, the technique ha...

    Authors: Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M. A. Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H. Buch, John P. Greenwood and Jacqueline Andrews

    Citation: Arthritis Research & Therapy 2018 20:266

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  46. Content type: Research article

    The aim of this global collaboration was to develop a consensual set of items for the analysis of synovial biopsies in clinical practice and translational research through the EULAR Synovitis Study Group (ESSG...

    Authors: Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon…

    Citation: Arthritis Research & Therapy 2018 20:265

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2018 20:282

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