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  1. The collaborative initiative of the European Network of Pregnancy Registers in Rheumatology (EuNeP) aims to combine data available in nationwide pregnancy registers to increase knowledge on pregnancy outcomes ...

    Authors: Yvette Meissner, Anja Strangfeld, Nathalie Costedoat-Chalumeau, Frauke Förger, Doreen Goll, Anna Molto, Rebecca Özdemir, Marianne Wallenius and Rebecca Fischer-Betz

    Citation: Arthritis Research & Therapy 2019 21:241

    Content type: Research article

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  2. A pivotal effect of lymphatic vessel (LV) function in joint homeostasis was identified in the tumor necrosis factor-transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA). Specifically, loss of LV contra...

    Authors: Richard D. Bell, Pamelia N. Slattery, Emily K. Wu, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz

    Citation: Arthritis Research & Therapy 2019 21:240

    Content type: Research article

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  3. Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. How...

    Authors: Jean-Marie Berthelot, Benoit Le Goff and Yves Maugars

    Citation: Arthritis Research & Therapy 2019 21:239

    Content type: Review

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  4. Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In ...

    Authors: Shikhar Mehta, Sumayyah Akhtar, Ryan M. Porter, Patrik Önnerfjord and Ambika G. Bajpayee

    Citation: Arthritis Research & Therapy 2019 21:238

    Content type: Research article

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  5. The aim of this retrospective study was to examine the longitudinal association between disease activity and radiographic damage in a cohort of patients with early RA (symptom onset < 1 year) treated according...

    Authors: Peter M. ten Klooster, Letty G. A. Versteeg, Martijn A. H. Oude Voshaar, Inmaculada de la Torre, Francesco De Leonardis, Walid Fakhouri, Liliana Zaremba-Pechmann and Mart van de Laar

    Citation: Arthritis Research & Therapy 2019 21:237

    Content type: Research article

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  6. Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded dive...

    Authors: Jing Chen, Yi Luo, Mengzhu Zhao, Di Wu, Yunjiao Yang, Wen Zhang and Min Shen

    Citation: Arthritis Research & Therapy 2019 21:236

    Content type: Research article

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  7. Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA).

    Authors: Ravi K. Narang, Zoe Vincent, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2019 21:234

    Content type: Research article

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  8. Over the past 20 years, the rheumatoid arthritis (RA) treatment landscape has been continuously evolving. A range of novel biologic agents, different from the conventional therapies, became available. However,...

    Authors: Teresa A. Simon

    Citation: Arthritis Research & Therapy 2019 21:232

    Content type: Editorial

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    The Research article to this article has been published in Arthritis Research & Therapy 2008 10:R45

  9. The ACR20 has been validated as the best discriminator of efficacy in placebo-controlled trials, but not in head-to-head trials comparing effective therapies in patients with rheumatoid arthritis (RA). We asse...

    Authors: Josef Smolen, Roy Fleischmann, Daniel Aletaha, Yihan Li, Yijie Zhou, Iain Sainsbury and Ivan Lagunes Galindo

    Citation: Arthritis Research & Therapy 2019 21:231

    Content type: Research article

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  10. The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine ...

    Authors: Kerry E. Poppenberg, Kaiyu Jiang, Lu Li, Yijun Sun, Hui Meng, Carol A. Wallace, Teresa Hennon and James N. Jarvis

    Citation: Arthritis Research & Therapy 2019 21:230

    Content type: Research article

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  11. For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. Due to the wi...

    Authors: Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel and Sophie Liabeuf

    Citation: Arthritis Research & Therapy 2019 21:229

    Content type: Research article

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  12. Patients with rheumatoid arthritis (RA) are at an increased risk of developing certain cancers and infections compared with the general population. Biologic and targeted synthetic disease-modifying antirheumat...

    Authors: Teresa A. Simon, Maarten Boers, Marc Hochberg, Nicole Baker, Mary L. Skovron, Nitesh Ray, Sanket Singhal, Samy Suissa and Andres Gomez-Caminero

    Citation: Arthritis Research & Therapy 2019 21:228

    Content type: Research article

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  13. A study by Raza et al., published in this journal in 2005, identified that RA patients, within 3 months of symptom onset, had a synovial fluid cytokine profile that was distinct from that of patients with othe...

    Authors: K. Raza

    Citation: Arthritis Research & Therapy 2019 21:226

    Content type: Editorial

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    The Research article to this article has been published in Arthritis Research & Therapy 2005 7:R784

  14. A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondyl...

    Authors: Désirée van der Heijde and Robert Landewé

    Citation: Arthritis Research & Therapy 2019 21:225

    Content type: Editorial

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    The Research article to this article has been published in Arthritis Research & Therapy 2009 11:R127

  15. Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogen...

    Authors: Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman and Johanne Martel-Pelletier

    Citation: Arthritis Research & Therapy 2019 21:224

    Content type: Research article

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  16. Fatigue is a common symptom of systemic autoimmune rheumatic disease (SARD). Patients with SARD have a protracted pre-clinical phase during which progressive immunologic derangements occur culminating in disea...

    Authors: Waleed Hafiz, Rawad Nori, Ariana Bregasi, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur A. M. Bookman, Sindhu R. Johnson, Carolina Landolt-Marticorena and Joan Wither

    Citation: Arthritis Research & Therapy 2019 21:223

    Content type: Research article

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  17. The aim of this study was to explore the impact of sex and disease classification on outcomes in axial spondyloarthritis (axSpA) patients, including both radiographic (r-) axSpA and non-radiographic (nr-) axSp...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Kenneth Egstrup, Xenofon Baraliakos, Vibeke Strand, Hans Christian Horn, Inger M. J. Hansen, Robin Christensen and Torkell Ellingsen

    Citation: Arthritis Research & Therapy 2019 21:221

    Content type: Research article

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  18. CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of CD38+ NK cells and the effect of C3G on RA.

    Authors: Hongxing Wang, Shutong Li, Guoqing Zhang, Hui Wu and Xiaotian Chang

    Citation: Arthritis Research & Therapy 2019 21:220

    Content type: Research article

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  19. The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis ...

    Authors: Zixuan Pan, Alberto M. Marra, Nicola Benjamin, Christina A. Eichstaedt, Norbert Blank, Eduardo Bossone, Antonio Cittadini, Gerry Coghlan, Christopher P. Denton, Oliver Distler, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Panagiota Xanthouli, Hanns-Martin Lorenz and Ekkehard Grünig

    Citation: Arthritis Research & Therapy 2019 21:217

    Content type: Research article

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  20. The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responder...

    Authors: Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson…

    Citation: Arthritis Research & Therapy 2019 21:216

    Content type: Research article

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  21. Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a multifactorial origin. While several disease-related ...

    Authors: Casper Webers, Laura Vanhoof, Carsten Leue, Annelies Boonen and Sebastian Köhler

    Citation: Arthritis Research & Therapy 2019 21:215

    Content type: Research article

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  22. The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis ...

    Authors: Philip G. Conaghan, Mikkel Østergaard, Orrin Troum, Michael A. Bowes, Gwenael Guillard, Bethanie Wilkinson, Zhiyong Xie, John Andrews, Amy Stein, Douglass Chapman and Andrew Koenig

    Citation: Arthritis Research & Therapy 2019 21:214

    Content type: Research article

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  23. Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensat...

    Authors: Jun Long, Xiaobo Wang, Xianfa Du, Hehai Pan, Jianru Wang, Zemin Li, Hui Liu, Xudong Li and Zhaomin Zheng

    Citation: Arthritis Research & Therapy 2019 21:213

    Content type: Research article

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  24. Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lympho...

    Authors: Ann-Christin Pecher, Felix Kettemann, Elisa Asteriti, Hannes Schmid, Silke Duerr-Stoerzer, Hildegard Keppeler, Joerg Christoph Henes, Reinhild Klein, Clemens Hinterleitner, Kathy-Ann Secker, Corina Schneidawind, Lothar Kanz and Dominik Schneidawind

    Citation: Arthritis Research & Therapy 2019 21:212

    Content type: Research article

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  25. To estimate and compare the burdens of opportunistic infections and herpes zoster in real-world practice among patients with various systemic rheumatic diseases.

    Authors: Chung-Yuan Hsu, Chi-Hua Ko, Jiun-Ling Wang, Tsai-Ching Hsu and Chun-Yu Lin

    Citation: Arthritis Research & Therapy 2019 21:211

    Content type: Research article

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  26. This study investigates the association between exposure to urate-lowering drugs (ULDs) and progression and recovery from chronic kidney disease (CKD).

    Authors: Ting-Ting Chung, Kuang-Hui Yu, Chang-Fu Kuo, Shue-Fen Luo, Meng-Jiun Chiou, Wen-Ching Lan, Jung-Sheng Chen, Wen-Yi Tseng, Ao-Ho Hsieh and Lian-Chin Wang

    Citation: Arthritis Research & Therapy 2019 21:210

    Content type: Research article

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  27. Fluorescence optical imaging (FOI) enables visualization of inflammation in the hands in rheumatic joint diseases with currently a lack of long-term follow-up studies.

    Authors: Anne-Marie Glimm, Lisa Ines Sprenger, Ida Kristin Haugen, Ulrich Mansmann, Sandra Hermann, Thomas Häupl, Paula Hoff, Gerd-Rüdiger Burmester, Marina Backhaus, Lien Le and Sarah Ohrndorf

    Citation: Arthritis Research & Therapy 2019 21:209

    Content type: Research article

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  28. If TNF inhibitors are initiated in the early stages of psoriatic arthritis, this could potentially modulate disease and therefore allow us to discontinue the TNF inhibitor after achieving remission.

    Authors: Henriëtte M. Y. de Jong, Leonieke J. J. van Mens, Michael T. Nurmohamed, Marc R. Kok, Arno W. R. van Kuijk, Dominique L. P. Baeten and Marleen G. H. van de Sande

    Citation: Arthritis Research & Therapy 2019 21:208

    Content type: Research article

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  29. To investigate the incidence of pneumocystis pneumonia (PCP) and its risk factors in patients with rheumatic disease receiving non-high-dose steroid treatment, along with the risks and benefits of PCP prophyla...

    Authors: Jun Won Park, Jeffrey R. Curtis, Min Jung Kim, Hajeong Lee, Yeong Wook Song and Eun Bong Lee

    Citation: Arthritis Research & Therapy 2019 21:207

    Content type: Research article

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  30. Osteoarthritis has been associated with a plethora of pathological factors and one which has recently emerged is chondrocyte endoplasmic reticulum (ER) stress. ER stress is sensed by key ER-resident stress sen...

    Authors: Louise H. W. Kung, Lorna Mullan, Jamie Soul, Ping Wang, Kazutoshi Mori, John F. Bateman, Michael D. Briggs and Raymond P. Boot-Handford

    Citation: Arthritis Research & Therapy 2019 21:206

    Content type: Research article

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  31. Neuropsychiatric systemic lupus erythaematosus (NP-SLE) is one of the major manifestations of lupus. However, the mechanisms involved in NP-SLE are still largely unknown. The abnormal activation of the type I ...

    Authors: Jing Zeng, Xinyu Meng, Ping Zhou, Zhihua Yin, Qinglian Xie, Hong Zou, Nan Shen, Zhizhong Ye and Yuanjia Tang

    Citation: Arthritis Research & Therapy 2019 21:205

    Content type: Research article

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  32. Rheumatoid arthritis (RA) is associated with an increased risk of morbidity and mortality, when compared with general population, largely due to enhanced atherosclerotic disease. In this work, we aimed at asse...

    Authors: Piero Ruscitti, Paola Cipriani, Vasiliki Liakouli, Daniela Iacono, Ilenia Pantano, Domenico Paolo Emanuele Margiotta, Luca Navarini, Giulia Maria Destro Castaniti, Nicola Maruotti, Gerardo Di Scala, Licia Picciariello, Francesco Caso, Sara Bongiovanni, Rosa Daniela Grembiale, Fabiola Atzeni, Raffaele Scarpa…

    Citation: Arthritis Research & Therapy 2019 21:204

    Content type: Research article

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  33. Excessive cartilage degradation is a known characteristic of osteoarthritis (OA). Biochemical markers, such as uCTX-II, have been shown to be associated with disease severity, yet the tissue origin of CTX-II h...

    Authors: Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis and Morten A. Karsdal

    Citation: Arthritis Research & Therapy 2019 21:203

    Content type: Research article

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  34. To determine the effect of riociguat, an oral, selective soluble guanylate cyclase stimulator, on the net digital ulcer (DU) burden in systemic sclerosis (SSc).

    Authors: Vivek Nagaraja, Cathie Spino, Erica Bush, Pei-Suen Tsou, Robyn T. Domsic, Robert Lafyatis, Tracy Frech, Jessica K. Gordon, Virginia D. Steen and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2019 21:202

    Content type: Research article

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  35. Intervertebral disc degeneration (IDD) has a complicated and enigmatic pathogenic process. Accumulating evidence shows that long non-coding RNAs (LncRNAs) play a role in the pathogenesis of IDD. This study aim...

    Authors: Shengfeng Zhan, Kun Wang, Yu Song, Shuai Li, Huipeng Yin, Rongjin Luo, Zhiwei Liao, Xinghuo Wu, Yukun Zhang and Cao Yang

    Citation: Arthritis Research & Therapy 2019 21:201

    Content type: Research article

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  36. Low doses of febuxostat or benzbromarone are widely used in Asian countries, but lacking studies to compare the efficacy and safety of the two urate-lowering drugs.

    Authors: Nan Liang, Mingshu Sun, Ruixia Sun, Ting Xu, Lingling Cui, Can Wang, Lidan Ma, Xiaoyu Cheng, Xiaomei Xue, Wenyan Sun, Xuan Yuan, Hui Zhang, Hailong Li, Yuwei He, Aichang Ji, Xinjiang Wu…

    Citation: Arthritis Research & Therapy 2019 21:200

    Content type: Research article

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  37. Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid ...

    Authors: Ayako Takaki-Kuwahara, Yojiro Arinobu, Kohta Miyawaki, Hisakata Yamada, Hirofumi Tsuzuki, Kensuke Irino, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Mitsuteru Akahoshi, Hiroshi Tsukamoto, Takahiko Horiuchi, Hiroaki Niiro and Koichi Akashi

    Citation: Arthritis Research & Therapy 2019 21:198

    Content type: Research article

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  38. The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA).

    Authors: Johanna Callhoff, Thomas Dietrich, Mariya Chubrieva, Jens Klotsche and Angela Zink

    Citation: Arthritis Research & Therapy 2019 21:197

    Content type: Research article

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  39. To investigate the risk of immune-mediated inflammatory diseases (IMIDs) in patients with ankylosing spondylitis (AS).

    Authors: Hsin-Hua Chen, Wen-Cheng Chao, Yi-Hsing Chen, Tsu-Yi Hsieh, Kuo-Lung Lai, Yi-Ming Chen, Wei-Ting Hung, Ching-Tsai Lin, Chih-Wei Tseng and Ching-Heng Lin

    Citation: Arthritis Research & Therapy 2019 21:196

    Content type: Research article

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  40. Structural variations such as copy number variations (CNVs) have a functional impact on various human traits. This study profiled genome-wide CNVs in Korean patients with rheumatoid arthritis (RA) to investiga...

    Authors: Ki-Nam Gu, So-Young Bang, Hye-Soon Lee, Youngho Park, Ju-Yeon Kang, Ji-Soong Kim, Bora Nam, Hyun-Seung Yoo, Jung-Min Shin, Yeon-Kyung Lee, Tae-Han Lee, Sehwan Chun, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim…

    Citation: Arthritis Research & Therapy 2019 21:195

    Content type: Research article

    Published on:

  41. Chondropathies are a group of cartilage diseases, which share some common pathogenetic features. The etiology of chondropathies is still largely obscure now.

    Authors: Ping Li, Yujie Ning, Xiong Guo, Yan Wen, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Sen Wang and Feng Zhang

    Citation: Arthritis Research & Therapy 2019 21:194

    Content type: Research article

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  42. Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. In this study, we explored the effect of the natural compo...

    Authors: Baofeng Chen, Hongmei Li, Guochun Ou, Long Ren, Xiaohong Yang and Mei Zeng

    Citation: Arthritis Research & Therapy 2019 21:193

    Content type: Research article

    Published on:

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