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  1. Research article

    Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

    A recent systematic review identified four candidate serum-soluble bone-turnover biomarkers (dickkopf-1, Dkk-1; macrophage-colony stimulating factor, M-CSF; matrix metalloproteinase-3, MMP-3; osteoprotegerin, ...

    Deepak R. Jadon, Raj Sengupta, Alison Nightingale, Hui Lu, Juliet Dunphy, Amelia Green, James T. Elder, Rajan P. Nair, Eleanor Korendowych, Mark A. Lindsay and Neil J. McHugh

    Arthritis Research & Therapy 2017 19:210

    Published on: 21 September 2017

  2. Research article

    Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

    Endoplasmic reticulum (ER) stress has proinflammatory properties, and transgenic animal studies of rheumatoid arthritis (RA) indicate its relevance in the process of joint destruction. Because currently availa...

    Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten and Kris A. Reedquist

    Arthritis Research & Therapy 2017 19:207

    Published on: 18 September 2017

  3. Research article

    Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment

    This study evaluates patient-reported outcomes (PROs) in a double-blind, phase III study of baricitinib as monotherapy or combined with methotrexate (MTX) in patients with active rheumatoid arthritis (RA) with...

    Michael Schiff, Tsutomu Takeuchi, Roy Fleischmann, Carol L. Gaich, Amy M. DeLozier, Douglas Schlichting, Wen-Ling Kuo, Ji-Eon Won, Tara Carmack, Terence Rooney, Patrick Durez, Saeed Shaikh, Rodolfo Pardo Hidalgo, Ronald van Vollenhoven and Cristiano A. F. Zerbini

    Arthritis Research & Therapy 2017 19:208

    Published on: 18 September 2017

  4. Review

    Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review

    Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest high-resolution computed tomography (HRCT) is presen...

    YuKai Wang, Luna Gargani, Tatiana Barskova, Dan E. Furst and Marco Matucci Cerinic

    Arthritis Research & Therapy 2017 19:206

    Published on: 18 September 2017

  5. Research article

    High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

    Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on ...

    Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song and Qiang Zhou

    Arthritis Research & Therapy 2017 19:209

    Published on: 18 September 2017

  6. Editorial

    Inflammasome lights up in systemic sclerosis

    Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement depen...

    John Henderson and Steven O’Reilly

    Arthritis Research & Therapy 2017 19:205

    Published on: 18 September 2017

  7. Research article

    Absence of ultrasound inflammation in patients presenting with arthralgia rules out the development of arthritis

    To decrease the burden of disease of rheumatoid arthritis (RA), patients at risk for RA need to be identified as early as possible, preferably when no clinically apparent synovitis can be detected. Up to now, ...

    Myrthe van der Ven, M. van der Veer-Meerkerk, D. F. Ten Cate, N. Rasappu, M. R. Kok, D. Csakvari, J. M. W. Hazes, A. H. Gerards and J. J. Luime

    Arthritis Research & Therapy 2017 19:202

    Published on: 15 September 2017

  8. Research article

    Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

    HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical feat...

    Tomoyuki Asano, Hiroshi Furukawa, Shuzo Sato, Makiko Yashiro, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Tomoyuki Ito, Yoshifumi Ubara, Daisuke Kobayashi, Nozomi Iwanaga, Yasumori Izumi, Keita Fujikawa, Satoshi Yamasaki, Tadashi Nakamura, Tomohiro Koga…

    Arthritis Research & Therapy 2017 19:199

    Published on: 12 September 2017

  9. Research article

    Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis

    Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA.

    Wadena D. Burnett, Saija A. Kontulainen, Christine E. McLennan, Diane Hazel, Carl Talmo, David R. Wilson, David J. Hunter and James D. Johnston

    Arthritis Research & Therapy 2017 19:200

    Published on: 12 September 2017

  10. Research article

    Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis

    Medial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information is available for relationships between MME and osteophytes, which are found in ca...

    Shinnosuke Hada, Muneaki Ishijima, Haruka Kaneko, Mayuko Kinoshita, Lizu Liu, Ryo Sadatsuki, Ippei Futami, Anwajan Yusup, Tomohiro Takamura, Hitoshi Arita, Jun Shiozawa, Takako Aoki, Yuji Takazawa, Hiroshi Ikeda, Shigeki Aoki, Hisashi Kurosawa…

    Arthritis Research & Therapy 2017 19:201

    Published on: 12 September 2017

  11. Research article

    Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

    Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytok...

    Hyemin Jeong, Eun-Kyung Bae, Hunnyun Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Chan Hong Jeon, Eun-Mi Koh and Hoon-Suk Cha

    Arthritis Research & Therapy 2017 19:198

    Published on: 7 September 2017

  12. Research article

    A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

    A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common c...

    Toshiki Nakajima, Hajime Yoshifuji, Masakazu Shimizu, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Masao Tanaka, Koichiro Ohmura, Fumihiko Matsuda, Chikashi Terao and Tsuneyo Mimori

    Arthritis Research & Therapy 2017 19:197

    Published on: 6 September 2017

  13. Commentary

    Opportunities and challenges in rheumatology research in Central Europe

    The Central European Congress of Rheumatology (CECR) has been organized by seven Central European countries: Austria, Croatia, Czech Republic, Hungary, Poland, Slovakia, and Slovenia. These countries have lots...

    Zoltán Szekanecz, Branimir Anic, Gábor Héjj, Iztok Holc, Aniella Hunka, Eugene Kucharz, Klaus Machold, Miroslav Mayer, Artur Pahor, Rudolf Puchner, Jozef Rovensky, Ladislav Senolt, Alena Tuchynova, Jiri Vencovsky and Josef S. Smolen

    Arthritis Research & Therapy 2017 19:196

    Published on: 4 September 2017

  14. Research article

    High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

    Although both rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) are useful for diagnosing rheumatoid arthritis (RA), the impact of these autoantibodies on the efficacy of tumor ...

    Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe and Takao Koike

    Arthritis Research & Therapy 2017 19:194

    Published on: 2 September 2017

  15. Research article

    Decrease in bone mineral density during three months after diagnosis of early rheumatoid arthritis measured by digital X-ray radiogrammetry predicts radiographic joint damage after one year

    Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a com...

    Michael Ziegelasch, Kristina Forslind, Thomas Skogh, Katrine Riklund, Alf Kastbom and Ewa Berglin

    Arthritis Research & Therapy 2017 19:195

    Published on: 2 September 2017

  16. Research article

    Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

    Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after s...

    Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park and Jason Jungsik Song

    Arthritis Research & Therapy 2017 19:193

    Published on: 25 August 2017

  17. Research article

    Biosemantics guided gene expression profiling of Sjögren’s syndrome: a comparative analysis with systemic lupus erythematosus and rheumatoid arthritis

    Sjögren's syndrome (SS) shares many clinical and pathological similarities with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). These autoimmune diseases mostly affect women. In this study, c...

    Nirav R. Shah, Braxton D. Noll, Craig B. Stevens, Michael T. Brennan, Farah B. Mougeot and Jean-Luc C. Mougeot

    Arthritis Research & Therapy 2017 19:192

    Published on: 17 August 2017

  18. Research article

    Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout

    To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of All...

    Leonard H. Calabrese, Arthur Kavanaugh, Anthony E. Yeo and Peter E. Lipsky

    Arthritis Research & Therapy 2017 19:191

    Published on: 17 August 2017

  19. Research article

    The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

    Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the bread...

    Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw

    Arthritis Research & Therapy 2017 19:190

    Published on: 15 August 2017

  20. Research article

    The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis

    Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood. Gut microbiota are known to be...

    Fei Teng, Krysta M. Felix, C. Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A. Raslan and Hsin-Jung Joyce Wu

    Arthritis Research & Therapy 2017 19:188

    Published on: 15 August 2017

  21. Research article

    Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

    Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the k...

    Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, René E. M. Toes…

    Arthritis Research & Therapy 2017 19:186

    Published on: 11 August 2017

  22. Research article

    Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

    Bortezomib (Bz) is a proteasome inhibitor that directly targets antibody-producing plasma cells. We recently reported the first randomized control trial that evaluated the effects of Bz in patients with system...

    Tomoko Ikeda, Hiroshi Fujii, Masato Nose, Yukiko Kamogawa, Tsuyoshi Shirai, Yuko Shirota, Tomonori Ishii and Hideo Harigae

    Arthritis Research & Therapy 2017 19:187

    Published on: 11 August 2017

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