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  1. Musculoskeletal (MSK) symptoms are among the commonest reasons for primary care assessments; however, few individuals will be diagnosed with an inflammatory arthritis (IA) within the following year. The purpos...

    Authors: Leticia Garcia-Montoya, Jacqueline L. Nam, Laurence Duquenne, Catalina Villota-Eraso, Andrea Di Matteo, Collette Hartley, Kulveer Mankia and Paul Emery

    Citation: Arthritis Research & Therapy 2022 24:26

    Content type: Research article

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  2. Intervertebral disc (IVD) herniation is characterized by annulus fibrosus failure (AF) in containing the nucleus pulposus (NP). IVD herniation involves cellular and extracellular matrix (ECM) alterations that ...

    Authors: A. L. Castro, C. Ribeiro-Machado, C. M. Oliveira, G. Q. Teixeira, C. Neidlinger-Wilke, P. Pereira, R. Vaz, M. A. Barbosa and R. M. Gonçalves

    Citation: Arthritis Research & Therapy 2022 24:25

    Content type: Research article

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  3. Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unkn...

    Authors: Zheni Stavre, Charles Bridgewood, Qiao Zhou, Yukiko Maeda, Ting-ting Huang, Jozsef Karman, Almas Khan, Sami Giryes, Kassem Sharif, Dennis McGonagle and Ellen M. Gravallese

    Citation: Arthritis Research & Therapy 2022 24:24

    Content type: Research article

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  4. Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA). In vivo, ACPAs target peptidyl-citrulline epitopes (cit-) in a variety of proteins (cit-prot-ACPAs) and derived ...

    Authors: Natalia Regine de França, Henri André Ménard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luís Eduardo Coelho Andrade and Inés Colmegna

    Citation: Arthritis Research & Therapy 2022 24:23

    Content type: Research article

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  5. The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, the latter experience a higher burden of disease and are affected more frequently by polyarthritis. Here, we performed an earl...

    Authors: E. Passia, M. Vis, L. C. Coates, A. Soni, I. Tchetverikov, A. H. Gerards, M. R. Kok, P. A. J. M. Vos, L. Korswagen, F. Fodili, Y. P. M. Goekoop-Ruiterman, J. van der Kaap, M. van Oosterhout and J. J. Luime

    Citation: Arthritis Research & Therapy 2022 24:22

    Content type: Research article

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  6. Little is known about the safety of SARS-CoV-2 vaccination in patients with rheumatic musculoskeletal disease (RMD). We evaluated the occurrence of adverse events following immunization (AEFI) in RMD patients ...

    Authors: Francesca Romana Spinelli, Ennio Giulio Favalli, Cristina Garufi, Martina Cornalba, Serena Colafrancesco, Fabrizio Conti and Roberto Caporali

    Citation: Arthritis Research & Therapy 2022 24:21

    Content type: Research article

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  7. Interstitial lung disease (ILD) is a common organ manifestation in systemic sclerosis (SSc) and is the leading cause of death in patients with SSc. A decline in forced vital capacity (FVC) is an indicator of I...

    Authors: Michael Kreuter, Francesco Del Galdo, Corinna Miede, Dinesh Khanna, Wim A. Wuyts, Laura K. Hummers, Margarida Alves, Nils Schoof, Christian Stock and Yannick Allanore

    Citation: Arthritis Research & Therapy 2022 24:19

    Content type: Research article

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  8. Synovial fluid (SF) is commonly used for diagnostic and research purposes, as it is believed to reflect the local inflammatory environment. Owing to its complex composition and especially the presence of hyalu...

    Authors: Hilde Brouwers, Johannes Hendrick von Hegedus, Enrike van der Linden, Rachid Mahdad, Margreet Kloppenburg, René Toes, Martin Giera and Andreea Ioan-Facsinay

    Citation: Arthritis Research & Therapy 2022 24:18

    Content type: Research article

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  9. Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear.

    Authors: Bing Wang, Hui Deng, Yao Hu, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Siyuan Wu, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang and Kexiang Yan

    Citation: Arthritis Research & Therapy 2022 24:17

    Content type: Research article

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  10. Although the risk of cardiovascular disease has been discussed extensively in both psoriasis (PsO) and psoriatic arthritis (PsA), very few studies have addressed the occurrence of venous thromboembolic (VTE) e...

    Authors: Tal Gazitt, Jacob Pesachov, Idit Lavi, Muna Elias, Amir Haddad, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba and Devy Zisman

    Citation: Arthritis Research & Therapy 2022 24:16

    Content type: Research article

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  11. The currently known risk loci could explain a small proportion of the heritability of ankylosing spondylitis (AS). Epigenetics might account for the missing heritability. We aimed to seek more novel AS-associa...

    Authors: Min Xiao, Xuqi Zheng, Xiaomin Li, Xinyu Wu, Yefei Huang, Qiujing Wei, Shuangyan Cao and Jieruo Gu

    Citation: Arthritis Research & Therapy 2022 24:15

    Content type: Research article

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  12. The relationship between IgG4-related disease (IgG4-RD) and the risk of malignancy is still controversial. This article focused on assessing the risk of cancer in patients with IgG4-RD by meta-analysis.

    Authors: Tingfeng Yu, Yaxian Wu, Jia Liu, Yanyan Zhuang, Xiaoyan Jin and Lingyun Wang

    Citation: Arthritis Research & Therapy 2022 24:14

    Content type: Research article

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  13. Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and...

    Authors: Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphaël Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frédéric Batteux, Jérôme Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon and Yannick Allanore

    Citation: Arthritis Research & Therapy 2022 24:13

    Content type: Research article

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  14. Lenabasum is a cannabinoid type 2 receptor (CB2R) reverse agonist that demonstrates anti-inflammatory effects in vivo and in vitro in dermatomyositis (DM) and is currently being investigated for therapeutic po...

    Authors: Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White and Victoria P. Werth

    Citation: Arthritis Research & Therapy 2022 24:12

    Content type: Research article

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  15. The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated.

    Authors: Clifton O. Bingham III, David Walker, Peter Nash, Susan J. Lee, Lei Ye, Hao Hu, Javaria Mona Khalid and Bernard Combe

    Citation: Arthritis Research & Therapy 2022 24:11

    Content type: Research article

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  16. This study aimed to investigate the effect of glucocorticoid doses on adverse pregnancy outcomes (APOs) in women complicated by systemic lupus erythematosus (SLE).

    Authors: Hiromi Shimada, Risa Wakiya, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Yusuke Ushio, Rina Mino, Mao Mizusaki, Tomohiro Kameda, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: Arthritis Research & Therapy 2022 24:10

    Content type: Research article

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  17. Seronegative antiphospholipid syndrome (SN-APS) is often defined as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. ...

    Authors: Gilberto Pires da Rosa, Bernardo Sousa-Pinto, Ester Ferreira, Olga Araújo, Giuseppe Barilaro, Paulo Bettencourt, Ricard Cervera and Gerard Espinosa

    Citation: Arthritis Research & Therapy 2022 24:9

    Content type: Research article

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  18. Hip osteoarthritis is a common disabling condition of the hip joint and is associated with a substantial health burden. We assessed the epidemiological patterns of hip osteoarthritis from 1990 to 2019 by sex, ...

    Authors: Ming Fu, Hongming Zhou, Yushi Li, Hai Jin and Xiqing Liu

    Citation: Arthritis Research & Therapy 2022 24:8

    Content type: Research article

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  19. Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease which encompasses patients with heterogenous presentation and a wide range of clinical courses. In this study, we aimed to identif...

    Authors: Takahiro Sugiyama, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yosuke Inaba, Shin-ichiro Kagami, Yasuhiko Kita, Kei Kobayashi, Yoshihisa Kobayashi, Kazuhiro Kurasawa, Daiki Nakagomi, Yasushi Nawata, Yohei Kawasaki, Yuki Shiko, Takao Sugiyama and Hiroshi Nakajima

    Citation: Arthritis Research & Therapy 2022 24:7

    Content type: Research article

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  20. Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions. As a classi...

    Authors: Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan and Hua-Feng Liu

    Citation: Arthritis Research & Therapy 2022 24:6

    Content type: Research article

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  21. Systemic lupus erythematosus (SLE) is a chronic and complex multi-system autoimmune disorder. Higher risks of hematological malignancies (HM) were observed in SLE patients, which was associated with higher mor...

    Authors: Yuqi Zhang, Wei Li, Panpan Zhang, Jinyan Guo, Jinlei Sun, Jiameng Lu and Shengyun Liu

    Citation: Arthritis Research & Therapy 2022 24:5

    Content type: Research article

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  22. Rheumatoid arthritis (RA) is a heterogeneous disease, as evidenced by the differences in long-term outcomes. This applies especially to anti-citrullinated protein antibodies (ACPA)-negative RA, where a proport...

    Authors: M. Verstappen, H. W. van Steenbergen, P. H. P. de Jong and A. H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2022 24:4

    Content type: Research article

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  23. To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations.

    Authors: Ting Zhang, Yong Du, Qingqing Wu, Hao Li, Thao Nguyen, Gabriel Gidley, Valeria Duran, Daniel Goldman, Michelle Petri and Chandra Mohan

    Citation: Arthritis Research & Therapy 2022 24:3

    Content type: Research article

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  24. Interstitial lung disease (ILD) is an important problem for patients with rheumatoid arthritis (RA). However, current approaches to ILD case finding in real-world data have been evaluated only in limited setti...

    Authors: M. Meehan, A. Shah, J. Lobo, J. Oates, C. Clinton, N. Annapureddy, F. Xie, J. Zhuo, M. I. Danila, B. R. England and J. R. Curtis

    Citation: Arthritis Research & Therapy 2022 24:2

    Content type: Research article

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  25. Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rode...

    Authors: Huanhuan Jia, Meili Chen, Yanzhen Cai, Xiaoling Luo, Gang Hou, Yongfeng Li, Chunmei Cai, Jun Chen, Qingnan Li, Kai-Kei Miu, Sin-Hang Fung, Zhangting Wang, Ren Huang, Huiyong Shen and Li Lu

    Citation: Arthritis Research & Therapy 2022 24:1

    Content type: Research article

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  26. In rheumatoid arthritis (RA), macrophages play an important role in modulating the immunoinflammatory response through their polarisation into “classically” (M1) or “alternatively activated” (M2) phenotypes. I...

    Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Samuele Tardito

    Citation: Arthritis Research & Therapy 2021 23:306

    Content type: Research article

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  27. To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS) using the novel Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system...

    Authors: Xia Zhang, Ruiling Feng, Jinxia Zhao, Yu Wang, Juan He, Li Liu, Yongjing Cheng, Haihong Yao, Sumei Tang, Jiali Chen, Shanshan Zhang, Zhiyi Zhang, Qingwen Wang, Jing He and Zhanguo Li

    Citation: Arthritis Research & Therapy 2021 23:305

    Content type: Research article

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  28. Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted a...

    Authors: Yeonghee Eun, In-Young Kim, Kyungdo Han, Kyu Na Lee, Dong-Yun Lee, Dong Wook Shin, Seonyoung Kang, Seulkee Lee, Hoon-Suk Cha, Eun-Mi Koh, Jaejoon Lee and Hyungjin Kim

    Citation: Arthritis Research & Therapy 2021 23:304

    Content type: Research article

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  29. There have been lacking reliable serum biomarkers in assessing the disease activity of Takayasu’s arteritis (TAK). This study aimed to assess the disease activity of TAK by assayed gene expression levels in pe...

    Authors: Yixiao Tian, Jing Li, Xinping Tian and Xiaofeng Zeng

    Citation: Arthritis Research & Therapy 2021 23:303

    Content type: Research article

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  30. The single nucleotide polymorphism (SNP) rs62324212, located in IL21 antisense RNA 1 (IL21-AS1), has been identified as a genetic risk variant associated with systemic lupus erythematosus (SLE). We aimed to pr...

    Authors: He Hao, Shingo Nakayamada, Naoaki Ohkubo, Kaoru Yamagata, Mingzeng Zhang, Yu Shan, Shigeru Iwata, Tong Zhang and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2021 23:302

    Content type: Research article

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  31. WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of ...

    Authors: Sungsin Jo, Subin Weon, Bora Nam, Mi-Ae Jang, Hyundeok Kang, Tae-Jong Kim, Ye-Soo Park and Tae-Hwan Kim

    Citation: Arthritis Research & Therapy 2021 23:301

    Content type: Research article

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  32. To determine the usefulness of power Doppler (PD) ultrasound (US) to predict rheumatoid arthritis (RA) development in patients with clinically suspect arthralgia (CSA).

    Authors: Juan Molina Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Javier Rivera, Fernando Montero, Carlos González and José María Álvaro-Gracia

    Citation: Arthritis Research & Therapy 2021 23:299

    Content type: Research article

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  33. Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically ca...

    Authors: M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes and D. van der Woude

    Citation: Arthritis Research & Therapy 2021 23:298

    Content type: Research article

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  34. Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for developing new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly u...

    Authors: Takao Sudo, Koji Akeda, Koki Kawaguchi, Takahiro Hasegawa, Junichi Yamada, Nozomu Inoue, Koichi Masuda and Akihiro Sudo

    Citation: Arthritis Research & Therapy 2021 23:297

    Content type: Research article

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  35. Features of new bone formation (NBF) are common in tophaceous gout. The aim of this project was to develop a plain radiographic scoring system for NBF in gout.

    Authors: Chang-Nam Son, Ken Cai, Sarah Stewart, John Ferrier, Karen Billington, Yun-Jung Jack Tsai, Thomas Bardin, Anne Horne, Lisa K. Stamp, Anthony Doyle and Nicola Dalbeth

    Citation: Arthritis Research & Therapy 2021 23:296

    Content type: Research article

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  36. Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature.

    Authors: Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue and Gregory Pugnet

    Citation: Arthritis Research & Therapy 2021 23:295

    Content type: Research article

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  37. The use of interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor as a treatment for the inflammatory joint disease is a promising method. However, its underlying mechanism in osteoarthritis (OA) remains...

    Authors: Muzhe Li, Huiyun Li, Xun Ran, Han Yin, Xuling Luo and Zhiwei Chen

    Citation: Arthritis Research & Therapy 2021 23:294

    Content type: Research article

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  38. Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified.

    Authors: Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu and Hajime Yoshifuji

    Citation: Arthritis Research & Therapy 2021 23:293

    Content type: Research article

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  39. Humidity was an unfavorable factor for patients with rheumatoid arthritis (RA). RA disease activity was severe in high humidity conditions. However, there is no evidence to demonstrate the effects of humidity ...

    Authors: Mingzhu Wang, Jiao Chen, Xiaoying Lin, Lin Huang, Haichang Li, Chengping Wen and Zhixing He

    Citation: Arthritis Research & Therapy 2021 23:292

    Content type: Research article

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  40. We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-...

    Authors: Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld and Timothy B. Niewold

    Citation: Arthritis Research & Therapy 2021 23:290

    Content type: Research article

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  41. Sjögren’s syndrome is a systemic autoimmune disease characterized by immune cells predominantly infiltrating the exocrine glands and frequently forming ectopic lymphoid structures. These structures drive a loc...

    Authors: Estelle Gerossier, Saba Nayar, Sylvie Froidevaux, Charlotte G. Smith, Celine Runser, Valentina Iannizzotto, Enrico Vezzali, Gabin Pierlot, Ulrich Mentzel, Mark J. Murphy, Marianne M. Martinic and Francesca Barone

    Citation: Arthritis Research & Therapy 2021 23:289

    Content type: Research article

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  42. Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA ...

    Authors: Bei Xu, Guanhua Xu, Ye Yu and Jin Lin

    Citation: Arthritis Research & Therapy 2021 23:288

    Content type: Review

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  43. Osteoarthritis (OA) subsequent to acute joint injury accounts for a significant proportion of all arthropathies. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor ce...

    Authors: Lixia Zhang, Cameron L. Kirkwood, Jiho Sohn, Ashley Lau, Mary Bayers-Thering, Supinder Kour Bali, Sridhar Rachala, John M. Marzo, Mark J. Anders, Frank Beier and Keith L. Kirkwood

    Citation: Arthritis Research & Therapy 2021 23:287

    Content type: Research article

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  44. Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-I...

    Authors: Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen and Gabriel Mbalaviele

    Citation: Arthritis Research & Therapy 2021 23:286

    Content type: Research article

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  45. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren

    Citation: Arthritis Research & Therapy 2021 23:285

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2021 23:269

  46. This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering alg...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh and Jaejoon Lee

    Citation: Arthritis Research & Therapy 2021 23:284

    Content type: Research article

    Published on:

  47. We have recently demonstrated that serum CCL20 levels positively correlate with mean pulmonary arterial pressure in patients with systemic sclerosis (SSc). Considering a proangiogenic effect of CCL20 on endoth...

    Authors: Tetsuya Ikawa, Takuya Miyagawa, Yuki Fukui, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Yuta Norimatsu, Yusuke Watanabe, Ayumi Yoshizaki, Shinichi Sato and Yoshihide Asano

    Citation: Arthritis Research & Therapy 2021 23:283

    Content type: Research article

    Published on:

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