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  1. Human cytomegalovirus (HCMV) seropositivity has been associated with higher inflammation during rheumatoid arthritis (RA). However, no data are available on the impact of HCMV seropositivity on bone erosion pr...

    Authors: B. Rauwel, Y. Degboé, D. Nigon, J.-F. Boyer, F. Abravanel, J. Izopet, B. Combe, A. Ruyssen-Witrand, A. Constantin, A. Cantagrel and J.-L. Davignon

    Citation: Arthritis Research & Therapy 2020 22:13

    Content type: Research article

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  2. We examined the association of three common chronic conditions (obesity, diabetes mellitus [DM], and cardiovascular disease [CVD]) with transitions among states of hip osteoarthritis (HOA).

    Authors: Carolina Alvarez, Rebecca J. Cleveland, Todd A. Schwartz, Jordan B. Renner, Louise B. Murphy, Joanne M. Jordan, Leigh F. Callahan, Yvonne M. Golightly and Amanda E. Nelson

    Citation: Arthritis Research & Therapy 2020 22:12

    Content type: Research article

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  3. Arthralgia and MRI-detected subclinical inflammation can precede the development of clinically evident rheumatoid arthritis (RA). However, part of the patients presenting with clinically suspect arthralgia (CS...

    Authors: Robin M. ten Brinck, Debbie M. Boeters, Hanna W. van Steenbergen and Annette H. M. van der Helm-van Mil

    Citation: Arthritis Research & Therapy 2020 22:11

    Content type: Research article

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  4. Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or...

    Authors: Andrew Henrey, Veronika Rypdal, Martin Rypdal, Thomas Loughin, Ellen Nordal and Jaime Guzman

    Citation: Arthritis Research & Therapy 2020 22:10

    Content type: Research article

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  5. Endocannabinoids are showing great promise as effective mediators for controlling joint inflammation and pain. One strategy that could be harnessed to promote endogenous cannabinoid function is to inhibit the ...

    Authors: Holly T. Philpott and Jason J. McDougall

    Citation: Arthritis Research & Therapy 2020 22:9

    Content type: Research article

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  6. The utility of generic health-related quality of life (HRQoL) questionnaires in patients with systemic lupus erythematosus (SLE) is uncertain. We compared the performance of generic (SF36) and specific (SLEQOL...

    Authors: Worawit Louthrenoo, Nuntana Kasitanon, Eric Morand and Rangi Kandane-Rathnayake

    Citation: Arthritis Research & Therapy 2020 22:8

    Content type: Research article

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  7. To explore the clinical patterns of patients with IgG4-related disease (IgG4-RD) based on laboratory tests and the number of organs involved.

    Authors: Jieqiong Li, Yu Peng, Yuelun Zhang, Panpan Zhang, Zheng Liu, Hui Lu, Linyi Peng, Liang Zhu, Huadan Xue, Yan Zhao, Xiaofeng Zeng, Yunyun Fei and Wen Zhang

    Citation: Arthritis Research & Therapy 2020 22:7

    Content type: Research article

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  8. Following publication of the original article [1], it was brought to our attention that the AOSD Consensus Group was incorrectly tagged and therefore not searchable. The publishers apologize for this error.

    Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia

    Citation: Arthritis Research & Therapy 2020 22:6

    Content type: Correction

    Published on:

    The original article was published in Arthritis Research & Therapy 2019 21:275

  9. To describe successful therapeutic strategies in statin-induced anti-HMGCR myopathy.

    Authors: Alain Meyer, Yves Troyanov, Julie Drouin, Geneviève Oligny-Longpré, Océane Landon-Cardinal, Sabrina Hoa, Baptiste Hervier, Josiane Bourré-Tessier, Anne-Marie Mansour, Sara Hussein, Vincent Morin, Eric Rich, Jean-Richard Goulet, Sandra Chartrand, Marie Hudson, Jessica Nehme…

    Citation: Arthritis Research & Therapy 2020 22:5

    Content type: Research article

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  10. Few studies have investigated patients’ own treatment goals in rheumatoid arthritis (RA). The objective of this real-world, cross-sectional study of US patients with RA was to identify factors that patients be...

    Authors: Kelly Gavigan, W. Benjamin Nowell, Mylene S. Serna, Jeffrey L. Stark, Mohamed Yassine and Jeffrey R. Curtis

    Citation: Arthritis Research & Therapy 2020 22:4

    Content type: Research article

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  11. We aimed to develop a patient-reported outcome measure, in accordance with the US Food and Drug Administration guidance, to capture the impact of systemic sclerosis-related digital ulcers (SSc-DUs) on hand fun...

    Authors: Luc Mouthon, Serge Poiraudeau, Margaret Vernon, Kelly Papadakis, Loïc Perchenet and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2020 22:3

    Content type: Research article

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  12. In the context of the scarcity of biomarkers for knee osteoarthritis (OA), we examined the associations of prevalent and incident OA with the expression levels of serum miRNAs in subjects with and without OA.

    Authors: Jean-Charles Rousseau, Marjorie Millet, Martine Croset, Elisabeth Sornay-Rendu, Olivier Borel and Roland Chapurlat

    Citation: Arthritis Research & Therapy 2020 22:2

    Content type: Research article

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  13. Early differentiation between different types of inflammatory arthritis and subsequent initiation of modern treatments can improve patient outcomes by reducing disease activity and preventing joint damage. Rou...

    Authors: Gurjit S. Kaeley, Catherine Bakewell and Atul Deodhar

    Citation: Arthritis Research & Therapy 2020 22:1

    Content type: Review

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  14. Systemic sclerosis (SSc) is a rare disease with studies limited by small sample sizes. Electronic health records (EHRs) represent a powerful tool to study patients with rare diseases such as SSc, but validated...

    Authors: Lia Jamian, Lee Wheless, Leslie J. Crofford and April Barnado

    Citation: Arthritis Research & Therapy 2019 21:305

    Content type: Research article

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  15. Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used ...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2019 21:304

    Content type: Research article

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  16. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of various autoantibodies. This disease causes disabling neuropsychiatric symptoms even in the absence of apparent in...

    Authors: Atsushi Nomura, Daisuke Noto, Goh Murayama, Asako Chiba and Sachiko Miyake

    Citation: Arthritis Research & Therapy 2019 21:303

    Content type: Research article

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  17. Systemic sclerosis (SSc), a life-threatening autoimmune disease characterized by vasculopathy. Numerous SSc patients demonstrate gastrointestinal (GI) involvement but the delicate GI bleeding risk remains spar...

    Authors: Yi-Ting Lin, Yun-Shiuan Chuang, Jiunn-Wei Wang and Ping-Hsun Wu

    Citation: Arthritis Research & Therapy 2019 21:301

    Content type: Research article

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  18. Osteoarthritis (OA) is an inflammatory disease of the joints that causes progressive disability in the elderly. Reactive oxygen species (ROS) play an important role in OA development; they may activate the NLR...

    Authors: Zhuming Chen, Huan Zhong, Jinsong Wei, Sien Lin, Zhixian Zong, Fan Gong, Xinqia Huang, Jinhui Sun, Peng Li, Hao Lin, Bo Wei and Jiaqi Chu

    Citation: Arthritis Research & Therapy 2019 21:300

    Content type: Research article

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  19. To determine the frequency and clinical characteristics of systemic sclerosis-related digital ulcers, and associated direct health care costs, quality of life, and survival.

    Authors: Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Gene-Siew Ngian, Nava Ferdowsi, Catherine L. Hill, Janet Roddy, Jennifer Walker, Susanna Proudman and Mandana Nikpour

    Citation: Arthritis Research & Therapy 2019 21:299

    Content type: Research article

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  20. Although disease in a majority of rheumatoid arthritis (RA) patients is often initially limited to one or a few joints, currently approved medications including anti-tumor necrosis factor-α antibody (α-TNF) ar...

    Authors: Kiyomitsu Katsumata, Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, Eiji Yuba, Erica Budina and Jeffrey A. Hubbell

    Citation: Arthritis Research & Therapy 2019 21:298

    Content type: Research article

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  21. Angiogenesis is an early event in the pathogenesis of both psoriatic arthritis (PsA) and rheumatoid arthritis (RA); however, there are striking differences in blood vessel morphology and activation between the...

    Authors: S. Fromm, C. C. Cunningham, M. R. Dunne, D. J. Veale, U. Fearon and S. M. Wade

    Citation: Arthritis Research & Therapy 2019 21:297

    Content type: Research article

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  22. CD4+ T cells play critical roles in the pathogenesis of IgG4-related disease (IgG4-RD). The aim of this study was to investigate the TCR repertoire of peripheral blood CD4+ T cells in IgG4-RD.

    Authors: Liwen Wang, Panpan Zhang, Jieqiong Li, Hui Lu, Linyi Peng, Jing Ling, Xuan Zhang, Xiaofeng Zeng, Yan Zhao and Wen Zhang

    Citation: Arthritis Research & Therapy 2019 21:295

    Content type: Research article

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  23. Treatment of patients with Sjögren’s syndrome (SjS) is a clinical challenge with high unmet needs. Gene expression profiling and integrative network-based approaches to complex disease can offer an insight on ...

    Authors: Hong Ki Min, Su-Jin Moon, Kyung-Su Park and Ki-Jo Kim

    Citation: Arthritis Research & Therapy 2019 21:294

    Content type: Research article

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  24. Sporadic inclusion body myositis (sIBM) is clinically characterised by progressive proximal and distal muscle weakness and impaired physical function while skeletal muscle tissue displays abnormal cellular inf...

    Authors: Kasper Yde Jensen, Mikkel Jacobsen, Henrik Daa Schrøder, Per Aagaard, Jakob Lindberg Nielsen, Anders Nørkær Jørgensen, Eleanor Boyle, Rune Dueholm Bech, Sofie Rosmark, Louise Pyndt Diederichsen and Ulrik Frandsen

    Citation: Arthritis Research & Therapy 2019 21:293

    Content type: Research article

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  25. To examine the ability of takinib, a selective transforming growth factor beta-activated kinase 1 (TAK1) inhibitor, to reduce the severity of murine type II collagen-induced arthritis (CIA), and to affect func...

    Authors: Scott A. Scarneo, Liesl S. Eibschutz, Phillip J. Bendele, Kelly W. Yang, Juliane Totzke, Philip Hughes, David A. Fox and Timothy A. J. Haystead

    Citation: Arthritis Research & Therapy 2019 21:292

    Content type: Research article

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  26. Systemic sclerosis is a multisystem inflammatory and vascular lesion leading to extensive tissue fibrosis. A reversible S-adenosyl-l-homocysteine hydrolase (SAHH) inhibitor, DZ2002, modulates the pathologic pr...

    Authors: Zongwang Zhang, Yanwei Wu, Bing Wu, Qing Qi, Heng Li, Huimin Lu, Chen Fan, Chunlan Feng, Jianping Zuo, Lili Niu and Wei Tang

    Citation: Arthritis Research & Therapy 2019 21:290

    Content type: Research article

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  27. The prevalence of osteoarthritis (OA) increases with obesity, with up to two thirds of the elderly obese population affected by OA of the knee. The metabolic syndrome (MetS), frequently associated with central...

    Authors: Bruce M. Dickson, Anke J. Roelofs, Justin J. Rochford, Heather M. Wilson and Cosimo De Bari

    Citation: Arthritis Research & Therapy 2019 21:289

    Content type: Review

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  28. Antibodies and upregulated cytokines and chemokines predate the onset of rheumatoid arthritis (RA) symptoms. We aimed to identify the pathways related to the early processes leading to RA development, as well ...

    Authors: Mikael Brink, Anders Lundquist, Andrey Alexeyenko, Kristina Lejon and Solbritt Rantapää-Dahlqvist

    Citation: Arthritis Research & Therapy 2019 21:288

    Content type: Research article

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  29. Identification of universal biomarkers to predict systemic lupus erythematosus (SLE) flares is challenging due to the heterogeneity of the disease. Several biomarkers have been reported. However, the data of v...

    Authors: Nopparat Ruchakorn, Pintip Ngamjanyaporn, Thanitta Suangtamai, Thanuchporn Kafaksom, Charin Polpanumas, Veerachat Petpisit, Trairak Pisitkun and Prapaporn Pisitkun

    Citation: Arthritis Research & Therapy 2019 21:287

    Content type: Research article

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  30. Systemic sclerosis is a systemic connective tissue disease characterized by endothelium damage, fibrosis, and subsequent atrophy of the skin. Perioral fibrosis produces a characteristic microstomia together wi...

    Authors: Roberto Pirrello, Barbara Verro, Giulia Grasso, Piero Ruscitti, Adriana Cordova, Roberto Giacomelli, Francesco Ciccia and Giuliana Guggino

    Citation: Arthritis Research & Therapy 2019 21:286

    Content type: Research article

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  31. Biosimilar infliximab has the potential for appreciable cost savings compared to its reference biologic, but dose escalation is common and increases costs. We compared frequency of dose escalation and associat...

    Authors: Jeffrey R. Curtis, Fenglong Xie, Jonathan Kay and Joel D Kallich

    Citation: Arthritis Research & Therapy 2019 21:285

    Content type: Research article

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  32. Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovitis and bone destruction at the joints, causing pain and motor disturbance. Despite the better control of inflammation and join...

    Authors: Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka and Fusao Kato

    Citation: Arthritis Research & Therapy 2019 21:284

    Content type: Research article

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  33. The inflammatory cascade in the rheumatoid arthritis (RA) synovium is modulated by a variety of cytokine and chemokine networks; however, the roles of IL-26, in RA pathogenesis, are poorly defined. Here, we in...

    Authors: Kyung-Ann Lee, Kyoung-Woon Kim, Bo-Mi Kim, Ji-Yeon Won, Hong Ki Min, Dhong Won Lee, Hae-Rim Kim and Sang-Heon Lee

    Citation: Arthritis Research & Therapy 2019 21:283

    Content type: Research article

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  34. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a promising tool for diagnosing relapsing polychondritis (RP). However, its usefulness in assessing RP with airway involv....

    Authors: Yunxiang Zeng, Minfang Li, Sheng Chen, Lin Lin, Shiyue Li, Jianxing He and Jinlin Wang

    Citation: Arthritis Research & Therapy 2019 21:282

    Content type: Research article

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  35. To compare the efficacy, serum drug concentrations, immunogenicity, and safety of FKB327 with the adalimumab reference product (RP) in combination with methotrexate in patients with moderate-to-severe, active ...

    Authors: Mark C. Genovese, Josephine Glover, Maria Greenwald, Wieslawa Porawska, Elias Chalouhi El Khouri, Eva Dokoupilova, Juan Ignacio Vargas, Mykola Stanislavchuk, Herbert Kellner, Elena Baranova, Nobuhito Matsunaga and Rieke Alten

    Citation: Arthritis Research & Therapy 2019 21:281

    Content type: Research article

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  36. The patients with RA benefit from early identification soon after the first clinical symptoms appear. The 2010 ACR/EULAR classification criteria were developed to fulfill this need and their application has be...

    Authors: Cristina Regueiro, Lorena Rodríguez-Martínez, Laura Nuño, Ana M. Ortiz, Alejandro Villalba, Dora Pascual-Salcedo, Ana Martínez-Feito, Isidoro González-Alvaro, Alejandro Balsa and Antonio Gonzalez

    Citation: Arthritis Research & Therapy 2019 21:280

    Content type: Research article

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  37. Bilateral hands including proximal interphalangeal joints (PIPJs) are recommended on physical, X-ray radiographic, or ultrasonographic examination by clinical guidelines of rheumatoid arthritis (RA), but MRI s...

    Authors: Ying-Qian Mo, Ze-Hong Yang, Jun-Wei Wang, Qian-Hua Li, Xin-Yun Du, T. W. Huizinga, X. M. E. Matthijssen, Guang-Zi Shi, Jun Shen and Lie Dai

    Citation: Arthritis Research & Therapy 2019 21:279

    Content type: Research article

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  38. Type V collagen (Col V) has the potential to become an autoantigen and has been associated with the pathogenesis of systemic sclerosis (SSc). We characterized serological, functional, and histopathological fea...

    Authors: Walcy Rosolia Teodoro, Zelita Aparecida de Jesus Queiroz, Lais Araujo dos Santos, Sergio Catanozi, Antonio dos Santos Filho, Cleonice Bueno, Margarete B. G. Vendramini, Sandra de Morais Fernezlian, Esmeralda M. Eher, Percival D. Sampaio-Barros, Sandra Gofinet Pasoto, Fernanda Degobbi T. Q. S. Lopes, Ana Paula Pereira Velosa and Vera Luiza Capelozzi

    Citation: Arthritis Research & Therapy 2019 21:278

    Content type: Research article

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  39. In the last few years, anti-CD20 antibody rituximab profoundly changed the therapeutic landscape of granulomatosis with polyangiitis (GPA). Here, we investigated whether natural killer (NK) cells may play a ro...

    Authors: Doris Urlaub, Shuyang Zhao, Norbert Blank, Raoul Bergner, Maren Claus, Theresa Tretter, Hanns-Martin Lorenz, Carsten Watzl and Wolfgang Merkt

    Citation: Arthritis Research & Therapy 2019 21:277

    Content type: Research article

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  40. The prevalence of lupus nephritis (LN) remains high despite various emerging monoclonal antibodies against with targeting systemic lupus erythematosus (SLE). Renal fibrosis is the main feature of late stage LN...

    Authors: Junjun Luan, Jingqi Fu, Chengjie Chen, Congcong Jiao, Weiwei Kong, Yixiao Zhang, Qing Chang, Yanqiu Wang, Detian Li, Gabor G. Illei, Jeffrey B. Kopp, Jingbo Pi and Hua Zhou

    Citation: Arthritis Research & Therapy 2019 21:276

    Content type: Research article

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  41. Adult-onset Still’s disease (AOSD) is a rare inflammatory condition characterized by fever, rash, and arthritis. Because of its rarity, clinical trials are inherently small and often uncontrolled. Our objectiv...

    Authors: Serena Colafrancesco, Maria Manara, Alessandra Bortoluzzi, Teodora Serban, Gerolamo Bianchi, Luca Cantarini, Francesco Ciccia, Lorenzo Dagna, Marcello Govoni, Carlomaurizio Montecucco, Roberta Priori, Angelo Ravelli, Paolo Sfriso and Luigi Sinigaglia

    Citation: Arthritis Research & Therapy 2019 21:275

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:6

  42. We wished to determine bone alterations in systemic sclerosis (SSc) patients by conventional densitometry (DXA), peripheral quantitative computed tomography (pQCT), and bone biomarkers.

    Authors: Ágnes Horváth, Edit Végh, Anita Pusztai, Zsófia Pethő, Attila Hamar, Monika Czókolyová, Harjit Pal Bhattoa, Gábor Nagy, Balázs Juhász, Katalin Hodosi, Andrea Domján, Zoltán Szekanecz, Gabriella Szücs and Szilvia Szamosi

    Citation: Arthritis Research & Therapy 2019 21:274

    Content type: Research article

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  43. To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7 years in a community-based sample of older adults.

    Authors: Guoqi Cai, Matthew Jiang, Flavia Cicuttini and Graeme Jones

    Citation: Arthritis Research & Therapy 2019 21:273

    Content type: Research article

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  44. To evaluate the effect of upadacitinib on patient-reported outcomes (PROs) in patients with RA who had an inadequate response to csDMARDs.

    Authors: Vibeke Strand, Janet Pope, Namita Tundia, Alan Friedman, Heidi S. Camp, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Debbie Goldschmidt and Michael Schiff

    Citation: Arthritis Research & Therapy 2019 21:272

    Content type: Research article

    Published on:

  45. Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases. In the current study, we aimed to explore how long noncoding RNA X-...

    Authors: Hongwei Chen, Shengdi Yang and Ruyi Shao

    Citation: Arthritis Research & Therapy 2019 21:271

    Content type: Research article

    Published on:

  46. PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharma...

    Authors: Spencer I. Danto, Negin Shojaee, Ravi Shankar P. Singh, Cheryl Li, Steven A. Gilbert, Zorayr Manukyan and Iain Kilty

    Citation: Arthritis Research & Therapy 2019 21:269

    Content type: Research article

    Published on:

  47. To investigate whether calprotectin (S100A8/A9 or MRP8/14), an inflammatory complex released by monocytes, could indicate residual subclinical inflammation in rheumatoid arthritis (RA) patients who are in stab...

    Authors: Emma C. de Moel, Jürgen Rech, Michael Mahler, Johannes Roth, Thomas Vogl, Anne Schouffoer, Robbert J. Goekoop, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Georg Schett and Diane van der Woude

    Citation: Arthritis Research & Therapy 2019 21:268

    Content type: Research article

    Published on:

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