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  1. This study aimed to investigate the relationship between radiological severity, as assessed by the individual grades and grouped grades (grades “0 and 1” and “2 to 4”) of the Kellgren-Lawrence scale (K&Ls), an...

    Authors: Isadora Cristina Ribeiro, Arlete Maria Valente Coimbra, Beatriz Lavras Costallat and Ibsen Bellini Coimbra

    Citation: Arthritis Research & Therapy 2020 22:187

    Content type: Research article

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  2. Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocy...

    Authors: Tobias Schmidt, Elisabet Berthold, Sabine Arve-Butler, Birgitta Gullstrand, Anki Mossberg, Fredrik Kahn, Anders A. Bengtsson, Bengt Månsson and Robin Kahn

    Citation: Arthritis Research & Therapy 2020 22:186

    Content type: Research article

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  3. Differences in the expression of variants across ethnic groups in the systemic lupus erythematosus (SLE) patients have been well documented. However, the genetic architecture in the Thai population has not bee...

    Authors: Pattarin Tangtanatakul, Chisanu Thumarat, Nusara Satproedprai, Punna Kunhapan, Tassamonwan Chaiyasung, Siriwan Klinchanhom, Yong-Fei Wang, Wei Wei, Jeerapat Wongshinsri, Direkrit Chiewchengchol, Pongsawat Rodsaward, Pintip Ngamjanyaporn, Thanitta Suangtamai, Surakameth Mahasirimongkol, Prapaporn Pisitkun and Nattiya Hirankarn

    Citation: Arthritis Research & Therapy 2020 22:185

    Content type: Research article

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  4. Endoplasmic reticulum (ER) stress is closely related with the pathological progression of rheumatoid arthritis (RA), and fibroblast-like synoviocytes (FLSs) are known as its resistance against ER stress-induce...

    Authors: Xiaomei Yang, Qingwei Guo, Tingting Feng, Qiqi Lu, Luna Ge, Jihong Pan, Kehong Bi, Li Qiao, Lei Tian, Tianhua Xie, Chengfang Yao, Guanhua Song and Lin Wang

    Citation: Arthritis Research & Therapy 2020 22:184

    Content type: Research article

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  5. Autologous hematopoietic stem cell transplantation (aHSCT) is a treatment option for a selected group of systemic sclerosis (SSc) patients with good available evidence but can be associated with considerable m...

    Authors: Michael Gernert, Hans-Peter Tony, Eva Christina Schwaneck, Matthias Fröhlich and Marc Schmalzing

    Citation: Arthritis Research & Therapy 2020 22:183

    Content type: Research article

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  6. The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese.

    Authors: Minh Duc Do, Thao Phuong Mai, Anh Duy Do, Quang Dinh Nguyen, Nghia Hieu Le, Linh Gia Hoang Le, Vu Anh Hoang, Anh Ngoc Le, Hung Quoc Le, Pascal Richette, Matthieu Resche-Rigon and Thomas Bardin

    Citation: Arthritis Research & Therapy 2020 22:182

    Content type: Research article

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  7. To determine the feasibility and validity of using wearable activity trackers to test associations between gout flares with physical activity and sleep.

    Authors: Nada Elmagboul, Brian W. Coburn, Jeffrey Foster, Amy Mudano, Joshua Melnick, Debra Bergman, Shuo Yang, Lang Chen, Cooper Filby, Ted R. Mikuls, Jeffrey R. Curtis and Kenneth Saag

    Citation: Arthritis Research & Therapy 2020 22:181

    Content type: Research article

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  8. Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum an...

    Authors: G. Marden, Q. Wan, J. Wilks, K. Nevin, M. Feeney, N. Wisniacki, M. Trojanowski, A. Bujor, L. Stawski and M. Trojanowska

    Citation: Arthritis Research & Therapy 2020 22:179

    Content type: Research article

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  9. Rheumatoid arthritis (RA) and periodontitis (PD) have been suggested to share many clinical and pathological features. However, few reports have investigated the relationship between the degree of PD and the t...

    Authors: Masahiro Tachibana, Yukio Yonemoto, Koichi Okamura, Takahito Suto, Hideo Sakane, Tetsuya Kaneko, Trang Thuy Dam, Chisa Okura, Tsuyoshi Tajika, Yoshito Tsushima and Hirotaka Chikuda

    Citation: Arthritis Research & Therapy 2020 22:178

    Content type: Research article

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  10. The Assessment of SpondyloArthritis international Society (ASAS) has defined core sets for (i) symptom-modifying anti-rheumatic drugs (SM-ARD), (ii) clinical record keeping, and (iii) disease-controlling anti-...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Xenofon Baraliakos, Vibeke Strand, Philip J. Mease, Maarten de Wit, Torkell Ellingsen, Inger Marie J. Hansen, Jamie Kirkham, George A. Wells, Peter Tugwell, Lara Maxwell, Maarten Boers, Kenneth Egstrup and Robin Christensen

    Citation: Arthritis Research & Therapy 2020 22:177

    Content type: Review

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  11. Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for r...

    Authors: Jin Kyun Park, Yu Jin Jang, Bo Ram Oh, Jieun Shin, Daekwon Bae, Nina Ha, Young il Choi, Gi Soo Youn, Jinseu Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song

    Citation: Arthritis Research & Therapy 2020 22:176

    Content type: Research article

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  12. Most patients with systemic lupus erythematosus (SLE) progress to lupus nephritis (LN) within 5 years of their SLE diagnosis, although it is not uncommon for LN to develop at later time points. Here we evaluat...

    Authors: Kunihiro Ichinose, Mineaki Kitamura, Shuntaro Sato, Keita Fujikawa, Yoshiro Horai, Naoki Matsuoka, Masahiko Tsuboi, Fumiaki Nonaka, Toshimasa Shimizu, Remi Sumiyoshi, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Takashi Igawa, Mami Tamai, Hideki Nakamura…

    Citation: Arthritis Research & Therapy 2020 22:175

    Content type: Research article

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  13. The interaction between galectin-9 (Gal-9) and its ligand, T cell immunoglobulin, and mucin-containing-molecule-3 (TIM-3), one of the coinhibitory receptors, transduce the inhibitory signaling to regulate immu...

    Authors: Yuya Fujita, Tomoyuki Asano, Haruki Matsumoto, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita

    Citation: Arthritis Research & Therapy 2020 22:174

    Content type: Research article

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  14. Infiltration of immune cells into the kidney is one of the key features of lupus nephritis (LN). The presence of immune cells in the urine may be used as a non-invasive biomarker of LN. Here, we aimed to analy...

    Authors: Jihye Kim, Jung Sun Lee, Heounjeong Go, Joon Seo Lim, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo and Seokchan Hong

    Citation: Arthritis Research & Therapy 2020 22:173

    Content type: Research article

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  15. Several metabolomics studies have shed substantial light on the pathophysiological pathways underlying multiple diseases including systemic lupus erythematosus (SLE). This review takes stock of our current und...

    Authors: Ting Zhang and Chandra Mohan

    Citation: Arthritis Research & Therapy 2020 22:172

    Content type: Review

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  16. Osteoarthritis (OA) is a whole joint disease that affects all joint tissues, with changes in the articular cartilage (AC), subchondral bone and synovium. Pathologies in menisci and ligaments, however, are rare...

    Authors: Lorenzo Ramos-Mucci, Behzad Javaheri, Rob van ‘t Hof, George Bou-Gharios, Andrew A. Pitsillides, Eithne Comerford and Blandine Poulet

    Citation: Arthritis Research & Therapy 2020 22:171

    Content type: Research article

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  17. Rheumatoid arthritis (RA) is classified as seropositive or seronegative, depending on the presence/absence of rheumatoid factor (RF), primarily IgM RF, and/or anti-citrullinated protein antibodies (ACPA), comm...

    Authors: Evan Reed, Anna Karin Hedström, Monika Hansson, Linda Mathsson-Alm, Boel Brynedal, Saedis Saevarsdottir, Martin Cornillet, Per-Johan Jakobsson, Rikard Holmdahl, Karl Skriner, Guy Serre, Lars Alfredsson, Johan Rönnelid and Karin Lundberg

    Citation: Arthritis Research & Therapy 2020 22:170

    Content type: Research article

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  18. Patients with gout have arterial dysfunction and systemic inflammation, even during intercritical episodes, which may be markers of future adverse cardiovascular outcomes. We conducted a prospective observatio...

    Authors: Michael Toprover, Binita Shah, Cheongeun Oh, Talia F. Igel, Aaron Garza Romero, Virginia C. Pike, Fatmira Curovic, Daisy Bang, Deana Lazaro, Svetlana Krasnokutsky, Stuart D. Katz and Michael H. Pillinger

    Citation: Arthritis Research & Therapy 2020 22:169

    Content type: Research article

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  19. Chondroclasts and osteoclasts have been previously identified as the cells capable of resorbing mineralized cartilage and bone matrices, respectively. While both cell types appear morphologically similar, cont...

    Authors: Nazir M. Khan, Kari B. Clifton, Joseph Lorenzo, Marc F. Hansen and Hicham Drissi

    Citation: Arthritis Research & Therapy 2020 22:168

    Content type: Research article

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  20. The cytokine, interleukin-23 (IL-23), can be critical for the progression of inflammatory diseases, including arthritis, and is often associated with T lymphocyte biology. We previously showed that certain lym...

    Authors: Kevin M.-C. Lee, Zihao Zhang, Adrian Achuthan, Andrew J. Fleetwood, Julia E. Smith, John A. Hamilton and Andrew D. Cook

    Citation: Arthritis Research & Therapy 2020 22:123

    Content type: Research article

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  21. To assess the diagnostic potential of IgG antibodies to citrullinated and corresponding native autoantigens in early arthritis.

    Authors: Stefan Vordenbäumen, Ralph Brinks, Patrick Schriek, Angelika Lueking, Jutta G. Richter, Petra Budde, Peter Schulz-Knappe, Hans-Dieter Zucht, Johanna Callhoff and Matthias Schneider

    Citation: Arthritis Research & Therapy 2020 22:167

    Content type: Research article

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  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Paul Emery, Yoshiya Tanaka, Tracy Cardillo, Douglas Schlichting, Terence Rooney, Scott Beattie, Cameron Helt and Josef S. Smolen

    Citation: Arthritis Research & Therapy 2020 22:166

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:115

  23. Progesterone receptor (PR) affects immunomodulation, and lack of PR in osteoprogenitor cells primarily affects pathways associated with immunomodulation, especially in males. In this study, we selectively dele...

    Authors: Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane and Wei Yao

    Citation: Arthritis Research & Therapy 2020 22:165

    Content type: Research article

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  24. Gout is a heterogeneous inflammatory disease with numerous clinical manifestations. A composite means to assess the impact of therapy on numerous aspects of gout could be useful.

    Authors: Naomi Schlesinger, N. Lawrence Edwards, Anthony E. Yeo and Peter E. Lipsky

    Citation: Arthritis Research & Therapy 2020 22:164

    Content type: Research article

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  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Per Nived, Göran Jönsson, Bo Settergren, Jon Einarsson, Tor Olofsson, Charlotte Sværke Jørgensen, Lillemor Skattum and Meliha C. Kapetanovic

    Citation: Arthritis Research & Therapy 2020 22:162

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:36

  26. Pepsin agglutinators, discovered over 50 years ago, have been recently referred to as anti-hinge antibodies (AHAs) because of their reaction with the IgG hinge epitope. AHAs have different reactivity for each ...

    Authors: Toshiyuki Ota, Shun-ichiro Ota, Ayumi Uchino and Shuji Nagano

    Citation: Arthritis Research & Therapy 2020 22:161

    Content type: Research article

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  27. The Src homology region 2 domain-containing phosphatase-1 (SHP-1) is known to exert negative regulatory effects on immune cell signaling. Mice with mutations in the Shp1 gene develop inflammatory skin disease and...

    Authors: Adrienn Markovics, Daniel M. Toth, Tibor T. Glant and Katalin Mikecz

    Citation: Arthritis Research & Therapy 2020 22:160

    Content type: Research article

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  28. Systemic lupus erythematosus (SLE) is associated with increased risk of cancer and the mechanism remains unclear. Here, we examined the level of auto-antibodies and disease activity index scores in SLE patient...

    Authors: Jinyan Guo, Zhigang Ren, Jianhao Li, Tianfang Li, Shengyun Liu and Zujiang Yu

    Citation: Arthritis Research & Therapy 2020 22:159

    Content type: Research article

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  29. Reliable assessment of remission is important for the optimal management of rheumatoid arthritis (RA) patients. In this study, we used the multi-biomarker disease activity (MBDA) test to explore the role of bi...

    Authors: M. H. Y. Ma, N. Defranoux, W. Li, E. H. Sasso, F. Ibrahim, D. L. Scott and A. P. Cope

    Citation: Arthritis Research & Therapy 2020 22:158

    Content type: Research article

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  30. We reported that the production of BAFF (B cell-activating factor) and IL-6, both of which are involved in survival and differentiation of B cells, is dysregulated in monocytes of patients with primary Sjögren...

    Authors: Keiko Yoshimoto, Katsuya Suzuki, Eriko Takei, Yumi Ikeda and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:157

    Content type: Research article

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  31. A comprehensive intuition of the systemic lupus erythematosus (SLE), as a complex and multifactorial disease, is a biological challenge. Dealing with this challenge needs employing sophisticated bioinformatics...

    Authors: Samaneh Maleknia, Zahra Salehi, Vahid Rezaei Tabar, Ali Sharifi-Zarchi and Kaveh Kavousi

    Citation: Arthritis Research & Therapy 2020 22:156

    Content type: Research article

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Yeong-Wook Song, Yi-Hsing Chen, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Yoshihiro Nakashima, Teruaki Shiomi and Emi Yamada

    Citation: Arthritis Research & Therapy 2020 22:155

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2020 22:47

  33. The aim of this study was to identify the molecular mechanism of dysregulation of B cell subpopulations of primary Sjögren’s syndrome (pSS) at the transcriptome level.

    Authors: Jun Inamo, Katsuya Suzuki, Masaru Takeshita, Yoshiaki Kassai, Maiko Takiguchi, Rina Kurisu, Yuumi Okuzono, Shinya Tasaki, Akihiko Yoshimura and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:153

    Content type: Research article

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  34. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expre...

    Authors: Aijing Liu, Fu-Dong Shi, Irun R. Cohen, Giuseppe Castaldo, Giuseppe Matarese, Francisco J. Quintana and Antonio La Cava

    Citation: Arthritis Research & Therapy 2020 22:152

    Content type: Research article

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  35. Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder of unknown aetiology usually affecting young adults. Interestingly, recent evidence from the juvenile counterpart of AOSD suggested the em...

    Authors: Piero Ruscitti, Onorina Berardicurti, Daniela Iacono, Ilenia Pantano, Vasiliki Liakouli, Francesco Caso, Giacomo Emmi, Rosa Daniela Grembiale, Francesco Paolo Cantatore, Fabiola Atzeni, Federico Perosa, Raffaele Scarpa, Giuliana Guggino, Francesco Ciccia, Antonio Barile, Paola Cipriani…

    Citation: Arthritis Research & Therapy 2020 22:151

    Content type: Research article

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  36. There is evidence that the cause of primary osteoarthritis (OA) is related to the changes in subchondral bone; however, the influence of subchondral insufficiency fracture (SIF) of the femoral head on the dege...

    Authors: Tomohiro Shimizu, Shunichi Yokota, Yosuke Kimura, Tsuyoshi Asano, Hirokazu Shimizu, Hotaka Ishizu, Norimasa Iwasaki and Daisuke Takahashi

    Citation: Arthritis Research & Therapy 2020 22:150

    Content type: Research article

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  37. Studies into ankylosing spondylitis (AS) and its relationship with immune imbalance are controversial, and the correlation between the efficacy of TNF-α inhibitor and changes in immune imbalance is unclear.

    Authors: Mingcan Yang, Qing Lv, Qiujing Wei, Yutong Jiang, Jun Qi, Min Xiao, Linkai Fang, Ya Xie, Shuangyan Cao, Zhiming Lin, Yanli Zhang, Liudan Tu, Minjing Zhao, Yunfeng Pan, Ou Jin and Jieruo Gu

    Citation: Arthritis Research & Therapy 2020 22:149

    Content type: Research article

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  38. Gout is the most prevalent inflammatory arthritis in developed countries. A gout flare is mediated by phagocytosis of monosodium urate crystals by macrophages and neutrophils leading to subsequent activation o...

    Authors: D. Vedder, M. Gerritsen, B. Duvvuri, R. F. van Vollenhoven, M. T. Nurmohamed and C. Lood

    Citation: Arthritis Research & Therapy 2020 22:148

    Content type: Research article

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  39. Approximately 50% of systemic lupus erythematosus (SLE) patients develop nephritis, which is among the most severe and frequent complications of the disease and a leading cause of morbidity and mortality. Desp...

    Authors: Orthodoxia Nicolaou, Kleitos Sokratous, Zuzanna Makowska, María Morell, Aurélie De Groof, Pauline Montigny, Andreas Hadjisavvas, Kyriaki Michailidou, Anastasis Oulas, George M. Spyrou, Christiana Demetriou, Marta E. Alarcón-Riquelme, Savvas Psarellis, Andreas Kousios, Bernard Lauwerys and Kyriacos Kyriacou

    Citation: Arthritis Research & Therapy 2020 22:147

    Content type: Research article

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  40. Despite the advances of rheumatoid arthritis (RA) therapeutics, several patients do not receive adequate treatment due to the toxicity and/or insufficient response of drugs. The aim of this study is to design ...

    Authors: You-Jung Ha, Sun-Mi Lee, Chin Hee Mun, Hyung Joon Kim, Yonghee Bae, Ji-Hee Lim, Kyu-Hyung Park, Soo-Kon Lee, Kyung-Hwa Yoo and Yong-Beom Park

    Citation: Arthritis Research & Therapy 2020 22:146

    Content type: Research article

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  41. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease that affects small- to medium-sized blood vessels. Despite treatments having been improved, patients often exper...

    Authors: Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto, Noriyasu Seki, Hideto Tsujimoto, Kenji Chiba and Tsutomu Takeuchi

    Citation: Arthritis Research & Therapy 2020 22:145

    Content type: Research article

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  42. Digital ulcers (DU) present a challenging complication in systemic sclerosis (SSc). The aim of this study was to combine clinical characteristics and imaging methods to a composite score for the prediction of ...

    Authors: S. Friedrich, S. Lüders, J. Klotsche, G. R. Burmester, G. Riemekasten and S. Ohrndorf

    Citation: Arthritis Research & Therapy 2020 22:144

    Content type: Research article

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  43. To assess whether age, at the beginning of biologic treatment, is associated with the time a first adverse event (AE) appears in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriat...

    Authors: Paloma Vela, Carlos Sanchez-Piedra, Carolina Perez-Garcia, María C. Castro-Villegas, Mercedes Freire, Lourdes Mateo, Cesar Díaz-Torné, Cristina Bohorquez, Juan M. Blanco-Madrigal, Inmaculada Ros-Vilamajo, Silvia Gómez, Rocio Caño, Fernando Sánchez-Alonso, Federico Díaz-González and Juan J. Gómez-Reino

    Citation: Arthritis Research & Therapy 2020 22:143

    Content type: Research article

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  44. This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of 7 biological disease-modifying antirheumatic drugs (bDMARDs) and tofacitinib (TOF), one of the janus k...

    Authors: Kosuke Ebina, Toru Hirano, Yuichi Maeda, Wataru Yamamoto, Motomu Hashimoto, Koichi Murata, Tohru Takeuchi, Hideyuki Shiba, Yonsu Son, Hideki Amuro, Akira Onishi, Kengo Akashi, Ryota Hara, Masaki Katayama, Keiichi Yamamoto, Atsushi Kumanogoh…

    Citation: Arthritis Research & Therapy 2020 22:142

    Content type: Research article

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  45. B cell depletion by rituximab (RTX) is an effective treatment for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). However, peripheral B cell phenotypes and the selection criteria f...

    Authors: Yusuke Miyazaki, Shingo Nakayamada, Satoshi Kubo, Yuichi Ishikawa, Maiko Yoshikawa, Kei Sakata, Shigeru Iwata, Ippei Miyagawa, Kazuhisa Nakano and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2020 22:141

    Content type: Research article

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  46. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes and Pilar Font

    Citation: Arthritis Research & Therapy 2020 22:140

    Content type: Correction

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    The original article was published in Arthritis Research & Therapy 2018 20:221

  47. The interleukin-6 receptor inhibitor sarilumab demonstrated efficacy in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or as monotherapy in patients with moderately to...

    Authors: Mark C. Genovese, Roy Fleischmann, Alan Kivitz, Eun-Bong Lee, Hubert van Hoogstraten, Toshio Kimura, Gregory St John, Erin K. Mangan and Gerd R. Burmester

    Citation: Arthritis Research & Therapy 2020 22:139

    Content type: Research article

    Published on:

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