- Paper Report
- Open Access
GI toxicity of celecoxib vs traditional NSAIDs
- Richard Brasington1
© Current Science Ltd 2000
- Published: 7 November 2000
- NSAID GI toxicity
The discovery of a second isoform of the cyclooxygenase enzyme, COX-2, led to the recognition that COX-2 is primarily responsible for mediating pain and inflammation, whereas COX-1 provides for gastric protection and other homeostatic functions. Selective inhibitors of COX-2 (coxibs) were developed based on the hypothesis that such agents could reduce inflammation and pain with less gastrointestinal (GI) toxicity than nonselective traditional nonsteroidal antiinflammatory drugs (NSAIDs). This study tests that hypothesis in patients with rheumatoid arthritis and osteoarthritis.
The annual incidence of symptomatic ulcers and ulcer complications (bleeding, perforation, and obstruction) was less in patients taking celecoxib 400 mg twice daily (0.44%) than in patients taking ibuprofen 800 mg three times a day or diclofenac 75 mg twice daily (1.27%), so long as they were not taking aspirin. In patients taking low-dose aspirin (up to 325 mg/day), the occurrence of adverse GI events was lower with celecoxib than with nonselective NSAIDs, although this difference did not achieve statistical significance.
Prospective, randomized controlled trial with active comparator
- Silverstein FE, Faich G, Goldstein JL, Simon LS, Pincus T, Whelton A, Makuch R, Eisen G, Agrawal NM, Stenson WF, Burr AM, Zhao WW, Kent JD, Lefkowith JB, Verburg KM, Geis GS: Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis. JAMA. 2000, 284: 1247-1255.PubMedView ArticleGoogle Scholar