In the etanercept group (n = 30), 26 patients (87%) met the Psoriatic Arthritis Response Criteria, compared with 7 patients (23%) in the placebo group (n = 30; P <0.0001). American College of Rheumatology 20% response criteria for RA (ACR 20) were acheived in 22 etanercept-taking patients compared with 4 taking placebo (P<0.0001).
ACR 50 was achieved in 50% and ACR 70 in 13% of the etanercept arm compared to 3% and 0% of the placebo group. Psoriasis could be assessed in 19 patients in both treatment groups. In the etanercept group, five out of 19 (26%) patients achieved 75% improvement in the psoriasis area and severity index compared with none in placebo group (P= 0.0154). Individual measures of arthritis also showed a significantly better response in the etanercept arm. No serious adverse event occurred in patients receiving etanercept. In conclusion, blocking TNF may offer a new therapeutic option in both PsA and psoriasis.