- Paper Report
- Open Access
Risk for hip OA in siblings
- Ali Hajeer1
© Current Science Ltd 2000
- Published: 22 December 2000
- total hip replacement
This study addresses whether hip osteoarthritis (OA) clusters in families using siblings of OA patients who have undergone total hip replacement. A recent study (see Additional information) using female twins from a population based, cross sectional study compared monozygotic and dizygotic twins for radiographic changes and estimated the total genetic contribution to hip OA to be about 60%.
The prevalence of hip OA in controls varied between 3.8-11% in women and 2.1-5.9% in men. Prevalence increased with age. The prevalence of hip OA among siblings was threefold to eightfold higher than controls; there was increased frequency of all grades of joint narrowing and osteophytes. Male siblings were at higher risk of developing hip OA, with an odds ratio (OR) of 6.4 for joint space narrowing (JSN) <2.5mm and 11.8 for JSN <1.5mm. The risk for females was less and did not vary with severity (OR 4.5 for JSN <2.5mm and 4.2 for JSN <1.5mm). Adjusting for nodal status and BMI did not alter OR.
Hip radiographs, OA patients and siblings compared to controls
MacGregor AJ, Antoniades L, Matson M, Andrew T, Spector TD: The genetic contribution to radiographic hip osteoarthritis in women: results of a classic twin study. Arthritis Rheum 2000, 43:2410-2416 (PubMedabstract).