- Paper Report
- Open Access
Glucosamine treatment of osteoarthritis of the knee
- Richard Brasington1
© Biomed Central Ltd 2001
- Received: 13 March 2001
- Published: 26 July 2001
- glucosamine sulfate
The functions of articular cartilage are dependent upon aggrecan, the predominant proteoglycan, and hyaluronan, which is composed of repeating glycosaminoglycan units of N-acetylglucosamine and glucuronic acid. Both hyaluronan and aggrecan are degraded in osteoarthritic cartilage. Use of glucosamine as a treatment of osteoarthritis has become widespread, despite the lack of evidence supporting its efficacy. This study tests the hypothesis that oral administration of glucosamine sulfate relieves symptoms and delays radiographic progression of osteoarthritis of the knee.
The group treated with glucosamine sulfate, 1500 mg/day, suffered less radiographic narrowing of the knee joint (0.06 mm versus 0.31 mm) than the placebo group. Furthermore, the glucosamine treated group experienced significant reduction of symptoms (WOMAC pain and function subscales). The authors conclude that glucosamine sulfate prevents the progression of osteoarthritis of the knee, in addition to relieving the symptoms.
Randomized, double-blind, placebo-controlled prospective clinical trial
Buckland-Wright JC, Wolfe F, Ward RJ, Flowers N, Haybne C: Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and schuss views.
J Rheumatol 1999, 26:2664-2674.