Context
Autoinflammatory syndromes are rare conditions defined by recurrent inflammatory symptoms. Phenotype varies among these diseases; however a subgroup is characterized by intermittent attacks of fever associated with rash and arthralgia. These diseases include familial mediterranean fever (FMF), hyper-IgD syndrome (HIDS), TNF receptor-associated periodic syndrome (TRAPS), familial cold autoinflammatory syndrome (FCAS), and Muckle-Wells syndrome (MWS). Mutations in the MEFV gene in FMF, mevalonate kinase in HIDS, and TNFR1 in TRAPS have been previously identified. In this paper the authors described a new gene (CIAS1) in which mutations are found in FCAS and MWS.