Response of PBMC to IFN-α/β (type I)/IFN-γ (type II) | Expression in SLE compared with control PBMC | |||||
---|---|---|---|---|---|---|
Gene | Protein | Reference: [4]* | [4]† | [5]‡ | [3]§ | [6]|| |
IFIT1 | Interferon-induced protein with tetratricopeptide repeats-1 | 18.3 | Up | Up | Up | |
OASL | 2'-5'-oligoadenylate synthetase-like | 16.3 | Up | Up | Up | |
LY6E | Lymphocyte antigen 6 complex, locus E | 14.9 | Up | Up | Up | Up |
OAS2 | 2'-5'-oligoadenylate synthetase | 12.7 | Up | Up | ||
OAS3 | 2'-5'-oligoadenylate synthetase | NA | NA | Up | ||
IFI44 | Hepatitis C microtubular aggregate protein | 10.7 | Up | Up | ||
MX1 | Myxovirus resistance 1 | 9.8 | Up | Up | Up | |
G1P3 | Interferon, alpha-inducible protein (IFI-6-16) | 7.1 | Up | Up | ||
PRKR | Protein kinase, interferon-α-inducible double-stranded RNA-dependent¶ | 6.9 | Up | Up | ||
IFIT4 | Interferon-induced protein with tetratricopeptide repeats 4 | 6.8 | Up | Up | Up | |
PLSCR1 | Phospholipid scramblase 1 | 6.6 | Up | Up | Up | |
C1ORF29 | Hypothetical protein expressed in osteoblasts; similar to IFI44 | 6.1 | Up | Up | Up | |
HSXIAPAF1 | XIAPassociated factor-1 | 6.1 | Up | Up | Up | |
G1P2 | Interferon, alpha-inducible protein (IFI-15K) | 5.9 | Up | Up | ||
Hs. 17518 (Cig5) | Viperin | 5.5 | Up | |||
IRF7 | Interferon regulatory factor 7 | 4.6 | Up | Up | ||
CD69 | Early T-cell activation antigen | 4.1 | Up | |||
LGALS3BP | Lectin, galactoside-binding, soluble, 3 binding protein | 3.8 | Up | Up | ||
IL1RN | Interleukin-1 receptor antagonist | 3.5 | Up | Up | ||
APOBEC3B | Phorbolin 1-like | 2.0 | Up | Up | Up | |
RGS1 | Regulator of G-protein signaling 1 | 1.8 | Up | |||
AGRN | Agrin | > 71.2 (γ → < 0) | Up | Up | ||
EREG | Epiregulin | 1.3 (α/β and γ → < 0) | Up | |||
THBS1 | Thrombospondin 1 | 1.3 (α/β and γ → < 0) | Up | |||
ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 | 1.2 (α/β and γ → < 0) | Up | |||
ADAM9 | A disintegrin and metalloproteinase domain 9 | 1.1 (α/β and γ → < 0) | Up | |||
SERPING1 | Serine (or cysteine) proteinase inhibitor (C1 inhibitor) | 0.85 | Up | Up | ||
USP20 | Ubiquitin specific protease 20 | 0.25 (α/β and γ → < 0) | Down | |||
MATK | Megakaryocyte-specific tyrosine kinase | < 0.13 (α/β → < 0) | Down | |||
FCGR1A | Fc fragment of IgG, high-affinity Ia receptor | 0.08 | Up | Up |