Table 3 Selected gene families overexpressed or underexpressed in SLE PBMC
Gene families overexpressed | Examples | Gene families underexpressed | Examples |
|---|---|---|---|
IFN target genes | See Table 2 | Transcription factors | TCF3, TCF7 |
TNF and TNF receptor families | TNFSF10 (TRAIL), TNFRSF10C (TRAIL receptor 3), TNFR6 (Fas) | Kinases | LCK |
Chemokines and chemokine receptors | CCR7, CXCR2 | T cell receptors | TCRB, TCRD |
Cell surface activation antigens | CD69 | C-type lectins | KLRB1 |
Fc receptors | FCGR1A, FCGR2A | ||
Metalloproteinases | MMP3, MMP9 | ||
Defensins | DEFA3, F2RPA |