Functional associations of genes selected as differentially expressed in patients with juvenile rheumatoid arthritis (JRA) and normal controls. Tabular data from differential expression analysis were analyzed using Pathway Assist software. The graphical output delineating a functionally related network of genes is shown. Genes that were expressed at higher levels in JRA patients are represented as red ovals. Genes expressed at higher levels in controls are represented as blue ovals. Major biologic processes related to these genes are represented as yellow rectangles. White ovals represent genes that are functionally related to the genes used for analysis. Upon addition of these genes, several functional connections among the genes being analyzed can be observed. Green squares signify that a defined regulatory relationship exits between genes. Blue squares signify that a putative regulatory relationship between genes has been identified but not biochemically defined. +, positive regulation; -, negative regulation.