Figure 5

Nitric oxide production by inducible nitric oxide synthase transduced chondrocytes. Chondrocytes were transduced with constant plaque forming units of adenoviral vector carrying the human inducible nitric oxide synthase gene as described in Materials and methods, incubated with variable concentrations of N-monomethyl-L-arginine (L-NMA), and the conditioned media nitrite measured 24 hours later. Values are the mean ± standard error of n = 6–12 (the standard errors lie within the area of the data point symbol). *P < 0.05 versus 0 L-NMA.