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Table 1 Summary of effects of p38 MAPK inhibition on proteoglycan synthesis

From: Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition

 

Proteoglycan synthesis

 

Basal

+ TGF-β

+ IGF-1/FCS

SB

No change

-

No change

IL-1

- -

- -

- -

IL-1 + SB*

+

No change

No change

  1. *Relative to IL-1 alone. FCS, fetal calf serum; IGF-1, insulin-like growth factor 1; SB, SB 203580; TGF-β, transforming growth factor beta.