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Figure 4 | Arthritis Res Ther

Figure 4

From: Attenuation of inflammatory polyarthritis in TNF transgenic mice by diacerein: comparative analysis with dexamethasone, methotrexate and anti-TNF protocols

Figure 4

Histopathologic assessment of joint destruction. Representative histologies of the ankle joints from experimental Tg197 mice displaying the lowest histopathologic scores in their group are shown here. Mice were treated either with (a, d) water for injection (WFI), (b, e) 2 mg/kg diacerein daily, or (c, f) 5 mg/kg anti-TNF antibody (CB0006) weekly for 5 weeks. Paraffin joint sections were stained with hematoxylin and eosin (panels a, b, and c) or safranin-O (panels d, e, and f). Arrow indicates synovial hyperplasia, asterisks indicate subchondral bone erosion, and the dotted line indicates cartilage degradation. Original magnification: 40×.

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Arthritis Research & Therapy

ISSN: 1478-6362

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