Bystander suppression of collagen-induced arthritis in mice fed ovalbumin

Table 1 Arthritis onset, maximum score, and area under the curve in mice fed ovalbumin (OVA) or a standard diet and then immunized with bovine collagen type II (BCII) or with BCII + OVA^a

Treatment		n	Day of arthritis onset (mean ± SEM)	Maximum arthritic score (mean ± SEM)	AUC of arthritic score from day 21 to day 44 (mean ± SEM)
Diet	Immunogen(s)
Standard	BCII	16	26.2 ± 0.6	8.8 ± 0.6	122 ± 9
OVA	BCII	16	27.2 ± 0.5	9.1 ± 0.6	114 ± 11
Standard	BCII + OVA	15	27.7 ± 0.2	8.1 ± 0.6	107 ± 9
OVA	BCII + OVA	16	30.4 ± 0.9*	6.8 ± 0.6**	75 ± 9*

^aData were derived from studies of the same mice as used in Fig. 4c. The area under the curve (AUC) represents arthritis progression. Statistical analysis was with the Mann–Whitney U test. *P < 0.05 versus OVA-fed and BCII-immunized mice as well as standard-fed and BCII + OVA-immunized mice; **P < 0.05 versus OVA-fed, BCII-immunized mice. SEM = standard error of the mean.

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