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Table 1 Arthritis onset, maximum score, and area under the curve in mice fed ovalbumin (OVA) or a standard diet and then immunized with bovine collagen type II (BCII) or with BCII + OVAa

From: Bystander suppression of collagen-induced arthritis in mice fed ovalbumin

Treatment n Day of arthritis
onset
(mean ± SEM)
Maximum
arthritic score
(mean ± SEM)
AUC of arthritic
score from day 21 to day 44
(mean ± SEM)
Diet Immunogen(s)     
Standard BCII 16 26.2 ± 0.6 8.8 ± 0.6 122 ± 9
OVA BCII 16 27.2 ± 0.5 9.1 ± 0.6 114 ± 11
Standard BCII + OVA 15 27.7 ± 0.2 8.1 ± 0.6 107 ± 9
OVA BCII + OVA 16 30.4 ± 0.9* 6.8 ± 0.6** 75 ± 9*
  1. aData were derived from studies of the same mice as used in Fig. 4c. The area under the curve (AUC) represents arthritis progression. Statistical analysis was with the Mann–Whitney U test. *P < 0.05 versus OVA-fed and BCII-immunized mice as well as standard-fed and BCII + OVA-immunized mice; **P < 0.05 versus OVA-fed, BCII-immunized mice. SEM = standard error of the mean.