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Table 1 Histopathologic assessment of ankle joints

From: Effect of phospholipase A2inhibitory peptide on inflammatory arthritis in a TNF transgenic mouse model: a time-course ultrastructural study

    % of total at indicated HS  
Treatment Time course (weeks) Joints scored HS 2 HS 3 HS 4 HS (Mean ± SEM)
None 4 10 0 90.0 10 3.30 ± 0.11a
P-NT.II* 1 4 100 0 0 2.12 ± 0.12
P-NT.II* 2 4 100 0 0 2.37 ± 0.12
P-NT.II* 3 4 75 25 0 2.50 ± 0.20
P-NT.II* 4 4 75 25 0 2.62 ± 0.31b
Scrambled-P-NT.II-treated (negative control peptide) 4 6 16.7 83.3 0 3.25 ± 0.17c
  1. *Tg197 mice injected (intraperitoneally) with the test peptide P-NT.II were killed at weekly intervals (N = 4 per group) for 4 weeks and their ankle joints examined. For untreated and negative control groups, ankle joints were harvested only at the end of the 4 weeks' study course for one-time examination. Histologic scoring was performed semiquantitatively by a blinded examiner. HS 2 = pannus and fibrous tissue formation and focal erosion of subchondral bone; HS 3 = articular cartilage destruction and bone erosion; HS 4 = extensive articular cartilage destruction and bone erosion. a versus b, b versus c = significantly different (P < 0.05; one-way analysis of variance with Bonferroni's multiple comparison test). HS, histopathologic score; SEM, standard error of the mean.