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Table 4 Vascularity

From: Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study

 

Baseline

Week 4

vWF skin

4738 ± 1353

430 ± 158**

vWF synovium

93121 ± 26511

32739 ± 7152*

αvβ3 skin

9780 ± 1631

3580 ± 518**

αvβ3 synovium

2003 ± 684

274 ± 97*

VEGF skin

8230 ± 1651

5675 ± 1700

VEGF synovium

1784 ± 540

674 ± 236

  1. Blood vessels positive for von Willebrand factor (vWF; all blood vessels) and αvβ3 (newly formed blood vessels) as well as expression of vascular endothelial growth factor (VEGF; integrated optical density/mm2) before and 4 weeks after initiation of infliximab therapy. The data are expressed as mean ± standard error of the mean. *P ≤ 0.05, **P ≤ 0.02, versus baseline.