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Figure 1 | Arthritis Res Ther

Figure 1

From: Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes

Figure 1

Effect of insulin-like growth factor (IGF)-1 and R3 IGF-1 (an analog of IGF-1 with a greatly reduced affinity for IGF-binding proteins) on total proteoglycan synthesis by human osteoarthritis chondrocytes. Cells were stimulated for 48 hours with 2.7 nM IGF-1 or R3 IGF-1 and total proteoglycan synthesis was measured. Data are expressed as the means and SEM of four replicates from a representative experiment (out of three independent cultures). Statistical differences from the control were measured using Student's t-test. ***P < 0.001.

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