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Table 1 Effect of enzymatic treatment on cell viability in cartilage wound edges 5 weeks after subcutaneous implantation in nude mice

From: Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation model

Zone

Unwounded

Not enzyme treated

Enzyme treated

Surface

1440 ± 175

1151 ± 133

2316 ± 209*

Middle

787 ± 160

866 ± 27

1097 ± 59*

Deep

646 ± 75

589 ± 16

960 ± 45*

  1. Cartilage was treated with hyaluronidase and collagenase or left untreated and implanted subcutaneously into nude mice for 5 weeks. The number of vital cells were counted in a 150-mm broad band along both sides of the wound edges, as well as in unwounded control areas in surface, middle and deep zones. *P < 0.05 versus unwounded areas and non-enzyme-treated wound areas.
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Arthritis Research & Therapy

ISSN: 1478-6362

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