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Figure 4 | Arthritis Res Ther

Figure 4

From: Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells

Figure 4

Role of co-transferred type II collagen (CII)-specific T cells in collagen-antibody-induced arthritis. Incidence (a) and severity (b) of arthritis in different groups of age-matched male mutated mouse collagen (MMC)-positive and MMC-negative littermates (n = 7–11) that were injected with either monoclonal antibodies (day 0), T cells (107, day 1) or antibodies and T cells. All mice were monitored for the development of arthritis for 38 days and were included in the calculations. MMC-positive mice injected with antibodies were compared with mice co-transferred with antibodies and T cells. *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.005. The error bars in (b) indicate SEM.

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Arthritis Research & Therapy

ISSN: 1478-6362

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