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Table 3 Deposition of IgG and complement factor C3c in knee joints of mice at various times after induction of immune-complex- mediated arthritis

From: FcγR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)




Mouse strain

6 h

24 h

24 h


128 ± 6

139 ± 4

152 ± 9

C57Bl/6 (control)

126 ± 4

140 ± 9

155 ± 7

  1. IgG and C3c were studied immunohistochemically. Deposition was assessed using an image analyser to measure the mean amount of blue light, as a measure of staining intensity, passing through a defined area in the tissue. Data are means ± SD for six mice. Significance was evaluated using Student's t test.