Figure 4

RNA from procoagulant and fibrinolytic genes in paws of mice with CIA, as analyzed by RPA. (a) Autoradiographic signals of RNA samples from eitherarthritic paws (CIA) or normal paws from nonimmunized (NI) animals. The single sample shown for each condition represents the typical, reproducible pattern obtained from the RPA analysis of four RNAs, each from a different animal. (b) Expression of genes studied during CIA, shown as the ratio of mRNA in arthritic to that in normal paws (CIA/NI), after correction for GAPDH signal. Values are means ± SEM of at least four different mRNA values from four different mice.  ^*P < 0.05, CIA versus NI values.