Volume 6 Supplement 3

Global Arthritis Research Network (GARN): 4th World Congress on Arthritis in Montreal

Open Access

Synovial cadherin-11

  • D Lee1,
  • H Kiener1,
  • S Agarwal1,
  • J Higgins1 and
  • M Brenner1
Arthritis Res Ther20046(Suppl 3):96


Published: 13 September 2004

Cadherin-11 is a homophilic adhesion molecule that is expressed on fibroblast-like synoviocytes. To investigate a role for cadherin-11 in modulating synovial function, we have examined the synovial architecture and inflammatory responses in cadherin-11 mutant mice. We find these mice display a hypoplastic synovial lining with decreased cellular condensation and reduced extracellular matrix deposition. When challenged with arthritogenic serum in the KRN anti-GPI antibody-induced arthritis model in mice, cadherin-11-deficient animals display resistance to arthritis development. In animals that do develop detectable swelling and inflammation, there is a noted absence of cartilage damage, compared with wild-type animals with arthritis. Moreover, the architecture of the synovial response to inflammation is disorganized. In contrast to wild-type arthritic mice in which the synovial lining undergoes marked hyperplasia, the cadherin-11-deficient synovial reaction lacks a clearly detectable lining layer and shows a disorganized random inflammatory reaction. These results support the concept that fibroblast-like synoviocytes are direct participants in the highly orchestrated synovial reaction that occurs in inflammatory arthritis. Furthermore, these results reveal a role for synovial cadherin-11 in regulating synovial fibroblast function both in the healthy state and in the pathologic context of inflammatory arthritis.

Authors’ Affiliations

Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Harvard Medical School


© The Author(s) 2004