Polymorphism | Location | Base | Change | Sequence | Amino acid change | Variant allele frequency in EGP subjects (%) (n = 92) | Variant allele frequency in ESTs (%) |
---|---|---|---|---|---|---|---|
ZFP36*1 | Promoter | 316 | C→A | CCCCC(C/A)ATCCG |  | 1.8 |  |
ZFP36*2 | Promoter | 359 | A→G | CGGTC(A/G)CGGCT |  | 47 |  |
ZFP36*3 | Promoter | 490 | C→A | CCGGC(C/A)CCGGC |  | 3.1 |  |
ZFP36*4 | Promoter | 492 | C→T | GGCCC(C/T)GGCCC |  | 0.6 |  |
ZFP36*5 | Intron | 1226 | G→A | GGGAA(G/A)CCGGG |  | 0.5 |  |
ZFP36*6 | Intron | 1256 | C→G | TAAGG(C/G)CTCGG |  | 0.5 |  |
ZFP36*7 | PCD (ex.2) | 1525 | C→T | CGGGA(C/T)CCTGG | P37→S | 0.6a | 0/127 |
ZFP36*8 | PCD (ex.2) | 1725 | C→T | TCGCG(C/T)TACAA | R103→R | 6.2 | 2/127 (1.6%) |
ZFP36*9 | PCD (ex.2) | 2235 | T→C | CCCTC(T/C)GTACA | S273→S | 4.2 | 1/69 (1.4%) |
ZFP36*10 | 3' UTR | 2980 | Del TT | TTTTT(delTT)GTAAT | Â | 7.6 | 62/249 (26%) |
 |  |  | (7T→5T) |  |  |  |  |
ZFP36*11 | PCD (ex.2) | 1807 | G→T | GCCTG(G/T)GCGAG | G131→C |  | 5/118 (4.2%) |
ZFP36*12 | PCD (ex.2) | 2112 | C→T | GCCTT(C/T)TCTGC | F232→F |  | 4/97 (4.1%) |
ZFP36*13 | PCD (ex.2) | 2184 | C→A | AGGGC)CA_ACTCC | A256→A |  | 10/94 (11%) |
ZFP36*15 | PCD (ex.2) | 3059 | A→C | TGCCT(C/T)CCGCT |  |  | 17/232 (7.3%) |