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Table 1 Polymorphisms in ZFP36 encoding human tristetraprolin

From: The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis

Polymorphism

Location

Base

Change

Sequence

Amino acid change

Variant allele frequency in EGP subjects (%) (n = 92)

Variant allele frequency in ESTs (%)

ZFP36*1

Promoter

316

C→A

CCCCC(C/A)ATCCG

 

1.8

 

ZFP36*2

Promoter

359

A→G

CGGTC(A/G)CGGCT

 

47

 

ZFP36*3

Promoter

490

C→A

CCGGC(C/A)CCGGC

 

3.1

 

ZFP36*4

Promoter

492

C→T

GGCCC(C/T)GGCCC

 

0.6

 

ZFP36*5

Intron

1226

G→A

GGGAA(G/A)CCGGG

 

0.5

 

ZFP36*6

Intron

1256

C→G

TAAGG(C/G)CTCGG

 

0.5

 

ZFP36*7

PCD (ex.2)

1525

C→T

CGGGA(C/T)CCTGG

P37→S

0.6a

0/127

ZFP36*8

PCD (ex.2)

1725

C→T

TCGCG(C/T)TACAA

R103→R

6.2

2/127 (1.6%)

ZFP36*9

PCD (ex.2)

2235

T→C

CCCTC(T/C)GTACA

S273→S

4.2

1/69 (1.4%)

ZFP36*10

3' UTR

2980

Del TT

TTTTT(delTT)GTAAT

 

7.6

62/249 (26%)

   

(7T→5T)

    

ZFP36*11

PCD (ex.2)

1807

G→T

GCCTG(G/T)GCGAG

G131→C

 

5/118 (4.2%)

ZFP36*12

PCD (ex.2)

2112

C→T

GCCTT(C/T)TCTGC

F232→F

 

4/97 (4.1%)

ZFP36*13

PCD (ex.2)

2184

C→A

AGGGC)CA_ACTCC

A256→A

 

10/94 (11%)

ZFP36*15

PCD (ex.2)

3059

A→C

TGCCT(C/T)CCGCT

  

17/232 (7.3%)

  1. The base numbers correspond to the following GenBank accession numbers: ZFP36 gene, M92844; tristetraprolin cDNA, NM_003407.1; tristetraprolin protein, NP_003398.1. Polymorphism numbering is consistent with that in [52]. Base refers to the base number in the genomic sequence M92844. The polymorphic changes are indicated as follows: A (original base or amino acid) → G (polymorphic base or amino acid), or (A/G) in the sequence column. EGP, Environmental Genome Project; ex. 2, exon 2; PCD, protein coding domain; 3'-UTR, 3'-untranslated region. Table modified from [52]. aThis SNP was also found in 2.4% of subjects from Durham, North Carolina (see the text). The change labeled 'Del TT' refers to the removal of two T residues, changing the normal seven consecutive T residues to five in the variant sequence.