Figure 2
Fold change distribution for genes differentially expressed in pre-inflamed joints, in paws with acute and chronic arthritis, in comparison with gene expression in normal paws of naive BALB/cSCID mice. Values indicate the number of genes that fall in the given range of expression. Negative numbers for expression levels indicate downregulation (e.g. a negative twofold change corresponds to downregulation to 0.5-fold). Spikes at ± 5-fold expression change represent the extremes of histogram when combining all genes with differential expression level greater than ± 5-fold. The Venn diagram (bottom) indicates the number of overlapping genes that were differentially expressed in pre-inflamed and arthritic joints.