Figure 5

Evaluation of proteoglycan loss in human tumour necrosis factor transgenic (hTNFtg) and JNK1^-/-hTNFtg mice. As shown by toluidine blue staining (a), arthritis leads to loss of proteoglycan (arrows) in the cartilage of hTNFtg and intercrossed JNK1^-/-hTNFtg mice (magnification 100×). The area of early cartilage damage (b) was similar in the two groups with arthritis, whereas the joints of wild-type (wt) and JNK1 knockout (JNK1^-/-) animals were unaffected. Vertical bars indicate standard deviation. JNK, c-Jun N-terminal kinase.