The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models

Table 2 Effects of interleukin (IL)-17 on chondrocyte metabolism and cartilage destruction

Condition	Family member	Inhibition proteoglycan synthesis	Proteoglycan breakdown	Proteoglycan depletion	Chondrocyte death	Cartilage surface erosion	Aggrecanase	MMPs	NO	References
Ex vivo	IL-17A	+	+					3, 13	+	[44,45,50]
	IL-17A	+	+				+	-		[47]
	IL-17E	+							+	[47]
	IL-17F	+	+							[11]
Single knee joint injection	IL-17A	-		+						[46]
Repeated knee joint injections	IL-17A			+			+	-		[44,46,47]
Overexpression, knee joint of naive mice	IL-17A			+	-	-				[41]
Overexpression, knee joint of CIA mice	IL-17A			++	++	++				[41]
Overexpression, knee joint of SCW mice	IL-17A			++	+	-				[41]

CIA, collagen-induced arthritis; MMP, matrix metalloproteinase; NO, nitric oxide; SCW, streptococcal cell wall-induced arthritis.

ISSN: 1478-6362