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Table 2 Effects of interleukin (IL)-17 on chondrocyte metabolism and cartilage destruction

From: The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models

Condition Family member Inhibition proteoglycan synthesis Proteoglycan breakdown Proteoglycan depletion Chondrocyte death Cartilage surface erosion Aggrecanase MMPs NO References
Ex vivo IL-17A + +      3, 13 + [44,45,50]
  IL-17A + +     + -   [47]
  IL-17E +        + [47]
  IL-17F + +        [11]
Single knee joint injection IL-17A -   +       [46]
Repeated knee joint injections IL-17A    +    + -   [44,46,47]
Overexpression, knee joint of naive mice IL-17A    + - -     [41]
Overexpression, knee joint of CIA mice IL-17A    ++ ++ ++     [41]
Overexpression, knee joint of SCW mice IL-17A    ++ + -     [41]
  1. CIA, collagen-induced arthritis; MMP, matrix metalloproteinase; NO, nitric oxide; SCW, streptococcal cell wall-induced arthritis.