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Figure 1 | Arthritis Res Ther

Figure 1

From: Building the synovium: cadherin-11 mediates fibroblast-like synoviocyte cell-to-cell adhesion

Figure 1

Schematic representation of the cadherin-11 adhesive junction. In the intercellular space, cadherin-11 extracellular domains interact with cadherin-11 extracellular domains of adjacent cells to mediate cell adhesion. Lateral clustering of cadherin molecules is required to form stable cell-to-cell contacts. The intracellular catenins bind to the cytoplasmic tail of cadherin-11. p120 catenin (p120ctn) binds the cadherin tail at the juxtamembrane domain, whereas β-catenin binds the distal domain, the β-catenin binding sequence. α-Catenin associates with β-catenin and is directly linked to the actin cytoskeleton.

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