Figure 1

(a) Six hours after intra-articular injection of β-tryptase, knee joint swelling is evident in wild-type (PAR-2^+/+) mice but is virtually absent in PAR-2 gene disrupted (PAR-2^-/-) mice (P < 0.001, n = 4). (b) Knee joint swelling 10 days after Freunds complete adjuvant (FCA) treatment is significantly inhibited by co-administration of 4-amidino phenyl pyruvic acid (APPA) with FCA (P = 0.014, n = 4).