ANKHvariants associated with ankylosing spondylitis: gender differences

Table 6 HBAT-e analyses using ANKH markers in four haplotype blocks defined in HapMap

Markers in the haplotype block	AS nuclear families (n = 226)	Testing specifically for affected women	Testing specifically for affected men
Additive model
rs26307, rs27356	[C,C]; 0.78; 39; 0.04	NS	[C,C]; 0.79; 24; 0.014
3088132, rs153929	NS	NS	NS
rs28006, rs25957	NS	[T,G]; 0.25; 19; 0.007	NS
ANKH-OR, D5S1991	[1,2]; 0.43; 57; 0.013	NS	NS
Recessive/dominant model
rs26307, rs27356	[C,C]; 0.78; 40; 0.02	NS	[C,C]; 0.79; 25; 0.004*
3088132, rs153929	[G,A]; 0.70; 32; 0.02	NS	NS
rs28006, rs25957	NS	[C,C]; 0.71; 18; 0.004*	NS
ANKH-OR, D5S1991	NS	NS	NS

Data are expressed as [allele]; allele frequency; number of informative families; P value.
*Significant P value after Bonferroni correction. (Because eight tests [four haplotypes and two models] were carried out in the haplotype-based association testing [HBAT]-e analyses, P < 0.00625 [0.05/8] is considered statistically significant.) AS, ankylosing spondylitis; NS, not significant.

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