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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1

Figure 1

Leptin synergizes with IL-1 in inducing nitric oxide synthase (NOS) type II. Synergistic effect of leptin (OB) on nitrite (NO2-) accumulation and NOS type II protein expression induced by IL-1. Stimulations were conducted in serum-free conditions (a,b) in ATDC5 chondrogenic cells and (c) in human primary chondrocytes. NO2- accumulation is selectively inhibited by aminoguanidine (AG) both in (d) ATDC5 cells and in (panel c) human primary chondrocytes. Values are expressed as mean ± standard error of the mean. WB, western blot.

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Arthritis Research & Therapy

ISSN: 1478-6362

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