Figure 3
Genealogical trees of B-cell clones found before therapy in VH5 family in patient A. The best matching germline VH gene segments are shown in ellipses. The letters in the circles refer to individual sequences. Upper circle, parental clones with the gene segments they are using. Dotted circles, deduced intermediates. The numbers alongside the arrows represent the number of mutations between the different sequences. Brackets, mutated codons; underlined, replacement mutations; italicised, mutation to stop codon.