The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration

Table 3 Effects of IL-1β on gene expression in cells from non- degenerate or degenerate intervertebral discs

Target	General trend	Tissues affected		Significant changes^a (P < 0.05)
		Origin of cells	Disease state
MMP-3	Increase (5- to 10-fold)	NP, AF	N, D	Non-degenerate NP and AF
MMP-13	Increase (5- to 10-fold)	NP	N, D	Non-degenerate NP
ADAMTS-4	Increase (8-fold)	NP	D	Degenerate NP
ADAMTS-5	No real trend	-	-	None
SOX6	Decrease (3- to 9-fold)	NP, AF	N	Non-degenerate NP
SOX9	Decrease (3-fold)	NP, AF	N	None
Collagen I	Decrease (5- to 10-fold)	NP, AF	N, D	Degenerate NP
Collagen II	Decrease (5- to 50-fold)	AF	N, D	None
Aggrecan	Decrease (3- to 7-fold)	NP, AF	N, D	Non-degenerate NP and AF
IL-1α	Increase (100-fold)	NP, AF	D	Degenerate NP
IL-1β	Increase (100-fold)	NP, AF	D	Degenerate NP
IL-1Ra	No real trend	-	-	None
IL-1RI	Decrease (2- to 10-fold)	NP, AF	N	None

^aSite of any significant change in gene expression. -, no effect seen; ADAMTS, a disintegrin and metalloproteinase with thrombospondin motifs; AF, annulus fibrosus; D, degenerate intervertebral disc; IL-1Ra, IL-1 receptor antagonist; IL1-RI, receptor, type I; MMP, matrix metalloproteinase; N, non-degenerate intervertebral disc; NP, nucleus pulposus.

ISSN: 1478-6362