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Table 1 Therapy for rheumatoid arthritis: unmet needs

From: Unmet needs in rheumatoid arthritis

Problem Details
Heterogeneity of the disease Some patients respond to DMARD monotherapy
  Not every patient responds to anti-TNF (mono or combination) therapy
  'Remission' rates
  What is the pathology/biologic process in each individual patient?
Toxicities Infections, immunogenecity, congestive heart failure, drug-induced vasculitis, etc
Costs Limits availability to may patients
  1. DMARD, disease-modifying antirheumatic drug; TNF, tumor necrosis factor.