Table 1 Therapy for rheumatoid arthritis: unmet needs
Problem | Details |
|---|---|
Heterogeneity of the disease | Some patients respond to DMARD monotherapy |
Not every patient responds to anti-TNF (mono or combination) therapy | |
'Remission' rates | |
What is the pathology/biologic process in each individual patient? | |
Toxicities | Infections, immunogenecity, congestive heart failure, drug-induced vasculitis, etc |
Costs | Limits availability to may patients |