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Table 2 Mitochondrial mutational burden data of OA and RA patient synoviocyte tissue and cultured fibroblasts

From: Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

   Number of mutations Total mutational burden (mutations/kbp) OA vs RAa
Mitochondrial mutational burden Nucleotides sequenced Initial Published polymorphisms removed Initial Published polymorphisms removed Initial Published Polymorphisms removed
Total
   Fibroblasts        
OA 18489 38 20 2.055 1.082   
RA 30503 101 65 3.311 2.131 ρ = 0.01 ρ = 6.9 × 10-3
   Tissue        
OA 37145 67 40 1.804 1.077   
RA 17663 60 42 3.397 2.378 ρ = 4 × 10-4 ρ = 5.1 × 10-4
Expressed
   Fibroblasts        
OA 6956 12 7 1.725 1.006   
RA 12394 28 26 2.259 2.098 ρ = 0.5 ρ = 0.10
   Tissue        
OA 15805 10 10 0.633 0.633   
RA 6397 16 14 2.501 2.189 ρ = 6 × 10-4 ρ = 2.7 × 10-3
  1. aTwo-tailed Fisher's exact test. kbp, kilobase pairs; OA, osteoarthritis; RA, rheumatoid arthritis.