Somatic mutations in the mitochondria of rheumatoid arthritis synoviocytes

Table 2 Mitochondrial mutational burden data of OA and RA patient synoviocyte tissue and cultured fibroblasts

		Number of mutations		Total mutational burden (mutations/kbp)		OA vs RA^a
Mitochondrial mutational burden	Nucleotides sequenced	Initial	Published polymorphisms removed	Initial	Published polymorphisms removed	Initial	Published Polymorphisms removed
Total
Fibroblasts
OA	18489	38	20	2.055	1.082
RA	30503	101	65	3.311	2.131	ρ = 0.01	ρ = 6.9 × 10^-3
Tissue
OA	37145	67	40	1.804	1.077
RA	17663	60	42	3.397	2.378	ρ = 4 × 10^-4	ρ = 5.1 × 10^-4
Expressed
Fibroblasts
OA	6956	12	7	1.725	1.006
RA	12394	28	26	2.259	2.098	ρ = 0.5	ρ = 0.10
Tissue
OA	15805	10	10	0.633	0.633
RA	6397	16	14	2.501	2.189	ρ = 6 × 10^-4	ρ = 2.7 × 10^-3

^aTwo-tailed Fisher's exact test. kbp, kilobase pairs; OA, osteoarthritis; RA, rheumatoid arthritis.

ISSN: 1478-6362