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Table 1 Clinical characteristics of SLE patients according to psychiatric symptoms and anti-Nedd5 C-ter IgG

From: Screening of an endothelial cDNA library identifies the C-terminal region of Nedd5 as a novel autoantigen in systemic lupus erythematosus with psychiatric manifestations

  Group Aa (n = 17) Group Ba (n = 34)
Characteristic Anti-Nedd5 C-ter IgG (n = 8) No anti-Nedd5 C-ter IgG (n = 9) Anti-Nedd5 C-ter IgG (n = 6) No anti-Nedd5 C-ter IgG (n = 28)
Age (y), mean (range) 38.6 (26–52) 37.1 (23–50) 34.5 (28–48) 37.2 (14–70)
Sex (males/females) 1/7 2/7 1/5 3/25
Disease duration (y), mean (range) 11.2 (7–21) 6.8 (0.5–19) 9 (5–15) 12.1 (0.5–24)
Arthritis, no. (%) 5 (62.5) 9 (100) 5 (83.3) 18 (64.2)
Neurological involvement, no. (%) 2 (25) 4 (44.4) 2 (33.3) 11 (39.2)
Renal involvement, no. (%) 3 (37.5) 0 3 (50) 9 (32.1)
Cytopenia, no. (%) 5 (62.5) 7 (77.7) 4 (66.6) 16 (57.1)
Serositis, no. (%) 2 (25) 2 (22.2) 2 (33.3) 8 (28.5)
SLEDAI >3, no. (%) 5 (62.5) 4 (44.4) 4 (66.6) 12 (42.8)
  1. aGroup A, patients with depression or psychosis; group B, patients without psychiatric manifestations other than anxiety. Differences between the groups as measured by the χ2 test were not statistically significant. SLE, systemic lupus erythematosus; SLEDAI, Systemic Lupus Erythematosus Disease Activity Index.