Figure 2

A toluidine blue stained sections of cartilage. (a) Cartilage cultured for 7 days shows an evenly stained matrix with typical rounded chondrocytes. Sections of cartilage incubated for (b) 7 days and (c) 14 days with M2139 show abnormal matrix morphology with the loss of toluidine blue, the development of a cellular layer at the surface and the development of hypertrophic chondrocytes.