Endothelial selectin deficiency does not influence anti-collagen antibody production in collagen immunized mice. Mouse serum anti-collagen IgG antibody concentration is not altered in single E-selectin and E/P-selectin mutant mice compared with wild-type mice at days 16 and 28 after collagen immunization. Wild-type and selectin mutant mice were administered collagen, and then at days 16 and 28 mice were bled and serum was measured for anti-collagen IgG. Although anti-collagen IgG was elevated in all the groups at day 28 compared with day 16, there were no differences in anti-collagen IgG between groups at the time points examined. Values are expressed as mean ± standard error of the mean. wt, wild-type.