Clinical and hematological markers of collagen-induced arthritis. (Top panel) Early responders to challenge (group I, square points) demonstrated a sharp and larger increase in C-reactive protein (CRP) than was observed for intermediate and late responders (respectively, group II, triangles; and group III, circles). (Panel 2) Animals with an early increase in CRP showed an early weight loss. Group III showed only a minor weight loss after day 28. The hematocrit values (panel 3) were decreased during periods of active inflammation, while platelets (panel 4) and neutrophils (panel 5) were increased Each data point in the graphs represents a mean value for at least 3 animals for group I (n = 6) and 5 animals for groups II and III (n = 12 and n = 13, respectively). Squares, early responders (group I); triangles, intermediate responders (group II); circles, late responders (group III).