Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis

Table 2 TNFRII 196R allele frequency, alone and associated with HLA-DR status, subdivided according to American College of Rheumatology criteria for diagnosis of rheumatoid arthritis

	TNFRII 196R allele		P	Concomitant presence of TNFRII 196R allele and at least one HLA-DR1/DR4 allele	P
Diagnosis	Absent	Present
RA (n = 156)	76 (48.7 %)	80 (51.3 %)	0.002	44 (71 %)	0.012
Non-RA (n = 122)	82 (67.2 %)	40 (32.8 %)		18 (29 %)

Using Fischer's exact test, the TNFRII 196R allele (P = 0.002; positive predictive value [PPV] 66.6%, negative predictive value [NPV] 51.9%; odds ratio [OR] 2.158, 95% confidence interval [CI] 1.284–3.641) and its concomitant presence with at least one HLA-DR1/DR4 allele (P = 0.012; PPV 71%, NPV 47.4%; OR 2.2, 95% CI 1.16–4.32) were found to be associated with diagnosis of rheumatoid arthritis (RA).

ISSN: 1478-6362