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Table 2 TNFRII 196R allele frequency, alone and associated with HLA-DR status, subdivided according to American College of Rheumatology criteria for diagnosis of rheumatoid arthritis

From: Association between the TNFRII 196R allele and diagnosis of rheumatoid arthritis

  TNFRII 196R allele P Concomitant presence of TNFRII 196R allele and at least one HLA-DR1/DR4 allele P
Diagnosis Absent Present    
RA (n = 156) 76 (48.7 %) 80 (51.3 %) 0.002 44 (71 %) 0.012
Non-RA (n = 122) 82 (67.2 %) 40 (32.8 %)   18 (29 %)  
  1. Using Fischer's exact test, the TNFRII 196R allele (P = 0.002; positive predictive value [PPV] 66.6%, negative predictive value [NPV] 51.9%; odds ratio [OR] 2.158, 95% confidence interval [CI] 1.284–3.641) and its concomitant presence with at least one HLA-DR1/DR4 allele (P = 0.012; PPV 71%, NPV 47.4%; OR 2.2, 95% CI 1.16–4.32) were found to be associated with diagnosis of rheumatoid arthritis (RA).